A5086652027- CAR-T cell therapy research
- Virus-based gene therapy research
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Neuroinflammation and Neurodegeneration Mechanisms
- Phagocytosis and Immune Regulation
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
Ludwig-Maximilians-Universität München
2016-2024
Urologische Klinik München
2024
Vita-Salute San Raffaele University
2016
Neuromyelitis optica is a paradigmatic autoimmune disease of the central nervous system, in which water-channel protein AQP4 target antigen
Deficiency of CD83 in thymic epithelial cells (TECs) dramatically impairs CD4 T cell selection. can exert cell-intrinsic and –extrinsic functions through discrete protein domains, but it remains unclear how CD83’s capacity to operate these alternative functional modules relates its crucial role TECs. In this study, using viral reconstitution gene function TECs, we found that transmembrane domain is necessary sufficient for Moreover, a ubiquitination-resistant MHCII variant restored selection...
Abstract Traumatic brain injury frequently affects the cerebral cortex, yet little is known about differential effects that occur if only gray matter (GM) damaged or also involves white (WM). To tackle this important question and directly compare similarities differences in reactive gliosis, we performed stab wound affecting GM WM (GM+) one restricted to (GM−) adult murine cortex. First, examined glial reactivity regions affected (WM GM) determined influence of on gliosis comparing same area...
Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such could be reproduced in autologous settings by TCR gene-engineered lymphocytes. We report that redirected either a broadly expressed Y-encoded H antigen or tumor-associated antigen, although poorly effective if individually transferred, when simultaneously...
<p>Assessing Disease State in ACT treated TRAMP mice.</p>
<div>Abstract<p>Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such could be reproduced in autologous settings by TCR gene–engineered lymphocytes. We report that redirected either a broadly expressed Y-encoded H antigen or tumor-associated antigen, although poorly effective if individually transferred,...
<p>Description of additional methods and procedures used in the study. Also includes Supplementary References.</p>
<p>Network hotspot analysis.</p>
<p>In vitro responsiveness of Tumor and Allo/Y-redirected T cells.</p>
<p>Assessing Disease State in ACT treated TRAMP mice.</p>
<p>Principal component and GSEA analyses of microarray data.</p>
<p>Phenotype of TCR-redirected T cells.</p>
<p>Combined Tumor+Allo/Y ACT prolong survival of mice with autochthonous adenocarcinomas the pancreas.</p>
<p>In vitro responsiveness of Tumor and Allo/Y-redirected T cells.</p>
<p>Combined Tumor+Allo/Y ACT prolong survival of mice with autochthonous adenocarcinomas the pancreas.</p>
<p>H&E analyses of CD3+ tumor-infiltrating cells.</p>
<p>Phenotype of TCR-redirected T cells.</p>
<p>T cells of host and HSCT origin do not participate to tumor recognition.</p>
<div>Abstract<p>Donor-derived allogeneic T cells evoke potent graft versus tumor (GVT) effects likely due to the simultaneous recognition of tumor-specific and host-restricted minor histocompatibility (H) antigens. Here we investigated whether such could be reproduced in autologous settings by TCR gene–engineered lymphocytes. We report that redirected either a broadly expressed Y-encoded H antigen or tumor-associated antigen, although poorly effective if individually transferred,...
<p>T cells of host and HSCT origin do not participate to tumor recognition.</p>