A5048926200- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Venous Thromboembolism Diagnosis and Management
- Stroke Rehabilitation and Recovery
- Intracerebral and Subarachnoid Hemorrhage Research
- Atrial Fibrillation Management and Outcomes
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrhythmias and Treatments
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Blood Pressure and Hypertension Studies
- Neurosurgical Procedures and Complications
- Health Systems, Economic Evaluations, Quality of Life
- Cardiovascular Function and Risk Factors
- ECG Monitoring and Analysis
- Cardiovascular Disease and Adiposity
- Heart Rate Variability and Autonomic Control
- Healthcare Systems and Practices
- Non-Invasive Vital Sign Monitoring
- Clinical practice guidelines implementation
- Advanced Neuroimaging Techniques and Applications
- Bone and Joint Diseases
- Peripheral Artery Disease Management
University of Calgary
2024
United Nations Economic and Social Commission for Asia and the Pacific
2021-2024
Health and Education Research Management and Epidemiologic Services (United States)
2023
Alberta Health Services
2018-2021
Deleted Institution
2021
University of Alberta
2016-2020
University of Alberta Hospital
2013-2020
Weatherford College
2020
The University of Melbourne
2018
University Hospital and Clinics
2018
Importance Age is a leading predictor of poor outcomes after brain injuries like stroke. The extent to which age associated with preexisting burdens changes, visible on neuroimaging but rarely considered in acute decision-making or trials, unknown. Objectives To explore the mediation functional outcome by markers frailty (hereinafter frailty) patients ischemic stroke receiving endovascular thrombectomy (EVT). Design, Setting, and Participants This cohort study was post hoc analysis Safety...
Early anticoagulation after cardioembolic stroke remains controversial because of the potential for hemorrhagic transformation (HT). We tested safety and feasibility initiating rivaroxaban ≤14 days stroke/transient ischemic attack.A prospective, open-label study patients with atrial fibrillation treated transient attack or (National Institute Health Stroke Scale <9). All underwent magnetic resonance imaging <24 hours initiation day 7. The primary end point was symptomatic HT at 7.Sixty...
Abstract Mobile Stroke Unit (MSU) expedites the delivery of intravenous thrombolysis in acute stroke patients. We further evaluated functional outcome patients shipped to a tertiary care centre or repatriated local hospitals after triage by MSU syndrome rural northern Alberta. Consecutive with suspected were included. On basis neurology consultation and, Computed Tomography findings, patients, who thrombolysed needed advanced transported Comprehensive center (CSC) (Triage CSC group). Other...
Improving door-to-needle times (DNTs) for thrombolysis of acute ischemic stroke patients improves outcomes, but participation in DNT improvement initiatives has been mostly limited to larger, academic medical centers with an existing interest quality improvement. It is not known whether can improve at a population level, including smaller community hospitals. This study aims determine the effect provincial collaborative intervention on and patient outcomes.A pre post cohort was conducted...
<h3>Importance</h3> Some patients have poor outcomes despite small infarcts after endovascular therapy (EVT), while others with large do well. Understanding why these discrepancies occur may help to optimize EVT outcomes. <h3>Objective</h3> To validate exploratory findings from the Endovascular Treatment for Small Core and Anterior Circulation Proximal Occlusion Emphasis on Minimizing CT Recanalization Times (ESCAPE) trial regarding pretreatment, treatment-related, posttreatment factors...
There is a need for non-invasive and accurate techniques assessment of severity atherosclerotic disease in the carotid arteries. Recently an automated single sweep three-dimensional ultrasound (3D US) technique became available. The aims this study were to evaluate feasibility reproducibility method cohort patients undergoing clinically indicated ultrasound.Consecutive with history stroke or transient ischemic attack (TIA) having plaque internal artery (ICA) recruited study. Imaging was...
In non-cardioembolic stroke patients, the cardiac manifestations of high blood pressure are particular interest. Emerging data suggest that echocardiographically determined left ventricular hypertrophy is independently associated with risk ischemic stroke. The primary objective this study was to evaluate frequency different patterns (LV) remodeling and in a group consecutive patients admitted or transient attack (TIA). particular, we were interested how often relative wall thickness (RWT)...
Background Evaluation of patients with a suspected stroke is one the most common neurological emergencies requiring rapid, comprehensive assessment by service to determine patient eligibility for timely reperfusion therapies. Prehospital evaluation may help improve selection and reduce avoidable admissions overcapacity emergency departments. Methods results We report on our early experience prehospital triage using mobile unit (MSU) equipped CT scanner in rural Alberta. During initial 4...
ABSTRACT: Objectives: The optimal timing of anticoagulation after ischemic stroke in atrial fibrillation (AF) patients is unknown. Our aim was to demonstrate the feasibility and safety initiating dabigatran therapy within 14 days transient attack (TIA) or minor AF patients. Patients Methods: A prospective, multi-center registry (NCT02415855) with treated acute stroke/TIA (National Institutes Health Stroke Scale (NIHSS) ≤ 3) onset. Baseline follow-up computed tomography (CT) scans were...
ABSTRACT BACKGROUND AND PURPOSE The purpose of this study was to compare Doppler ultrasound (DUS) other angiographic modalities: computed tomography angiography (CTA), magnetic resonance (MRA), and digital subtraction (DSA). METHODS All DUS studies performed at Stroke Prevention Clinic (SPC) from 2011 2013 referred for further modalities were included. Patients excluded if the corresponding modality not within 6 months DUS. also they underwent interventions before or between time modality....
Abstract Rationale: Idarucizumab is a specific reversal agent for patients with bleeding related to the anticoagulant dabigatran. There are no prior descriptions of administration in prehospital setting intracranial hemorrhage. Patient concerns: An 82-year-old woman treated dabigatran atrial fibrillation developed acute focal weakness. This led activation emergency medical services and assessment mobile stroke unit (MSU). Diagnosis: Computed tomography brain performed MSU revealed an...
Background Subacute ischemic lesions in intracerebral hemorrhage ( ICH ) have been hypothesized to result from hypoperfusion. Although studies of cerebral blood flow CBF indicate modest hypoperfusion , these investigations limited early time points. Arterial spin labeling ASL ), a magnetic resonance imaging technique, can be used measure without contrast agent. We assessed patients with using and tested the hypothesis that is related systolic pressure SBP ). Methods Results In this...
Introduction: Atrial fibrillation (AF) is a leading cause of preventable stroke and can be prevented with anticoagulants. Prolonged cardiac monitoring lead to better detection AF. Real time may earlier diagnosis treatment. Objective: Primary objective detect AF using wireless cardiophone for 14 days in patients. Secondary determine the reduction resulting prompt change clinical management. Method: This was Cohort/Prospective study at Univesity Alberta Hospital. Patients ≥40 years age...
Introduction: Early anticoagulation after cardioembolic stroke remains controversial, due to the potential for symptomatic hemorrhagic transformation (HT). The safety profile of rivaroxaban within 14 days onset has not been assessed prospectively. Methods: We conducted a prospective, open label study patients with atrial fibrillation treated ≤14 mild/moderate ischemic stroke/TIA (NIHSS score≤8) onset. Informed consent was obtained decision treat made by treating physician. All underwent MRI,...
Introduction: Recent evidence has shown that prolonged cardiac monitoring is superior to 24 hour Holter for detection of atrial fibrillation (AF). We compared two methods in patients with acute ischemic stroke and TIAs. Objective: Comparison the Cardiophone Sorin monitor AF. Method: In first part study (PEAACE I; 2011-2013), we used spiderflash (Sorin, Italy) up 21 days monitoring. second II; 2013-2015), real time heart rhythm 14 was used. Results: 102 PEAACE I, (Mean age 72 +/-, 48.8% male)...
Introduction: Diffusion-Weighted magnetic resonance imaging (DWI) studies have demonstrated sub-acute ischemic lesions in up to 41% of patients with intracerebral hemorrhage (ICH). Retrospective indicated an association acute blood pressure (BP) reduction. We conducted a prospective study DWI lesion incidence ICH patients. Methods: Patients computed tomography (CT) scan confirmed were prospectively recruited within 6 hours symptom onset. Acute systolic BP (SBP) targets randomly assigned as...
Introduction: Perihematomal hypoperfusion in acute intracerebral hemorrhage (ICH) has been demonstrated using CT perfusion. Although blood pressure (BP) reduction does not appear to impact perihematomal Cerebral Blood Flow (CBF), measurements contrast are limited a single time point. It also shown that up 41% of ICH patients develop subacute diffusion-weighted imaging (DWI) lesions on MRI. Arterial Spin Labelling (ASL) is an magnetic resonance (MRI) technique allows measurement CBF without...