A5079590771- Bacteriophages and microbial interactions
- Infective Endocarditis Diagnosis and Management
- Cancer Research and Treatments
- Microbial infections and disease research
- Infectious Aortic and Vascular Conditions
- Congenital Heart Disease Studies
- Prenatal Screening and Diagnostics
- Fetal and Pediatric Neurological Disorders
- Transplantation: Methods and Outcomes
- Nanopore and Nanochannel Transport Studies
- Vascular Procedures and Complications
- Polyomavirus and related diseases
- Renal and Vascular Pathologies
- Hemostasis and retained surgical items
- Abdominal vascular conditions and treatments
- Monoclonal and Polyclonal Antibodies Research
- Plant Virus Research Studies
- Respiratory viral infections research
- Actinomycetales infections and treatment
- Protein purification and stability
- Aquaculture disease management and microbiota
- Polymer Surface Interaction Studies
- Bacterial Identification and Susceptibility Testing
Medizinische Hochschule Hannover
2015-2025
(1) Objective: Bacterial resistance to conventional antibiotic therapy is an increasingly significant worldwide challenge human health. The objective evaluate whether bacteriophage could complement or be a viable alternative in critical cases of bacterial infection related cardiothoracic surgery. (2) Methods: Since September 2015, eight patients with multi-drug resistant especially recalcitrant Staphylococcus aureus, Enterococcus faecium, Pseudomonas aeruginosa, Klebsiella pneumoniae, and...
Abstract Fibrin glue has been used clinically for decades in a wide variety of surgical specialties and is now being investigated as medium local, prolonged drug delivery. Effective local delivery antibacterial substances important perioperatively patients with implanted medical devices or postoperatively deep wounds. However, application antibiotics often not possible simply inadequate. Biofilm formation antibiotic resistance are also major obstacles to therapy. In this paper we test the...
Abstract The escalating challenges of antibiotic resistance in bacterial pathogens have necessitated the exploration alternative therapeutic strategies. Among these, bacteriophage therapy has regained attention as a promising approach to combat multidrug-resistant bacteria. Bacteriophages are viruses that infect and lyse specific strains, making them attractive candidates for targeted antimicrobial treatment. Burkholderia multivorans , Gram-negative bacterium, is known cause opportunistic...
(1) Background: Implant-associated bacterial infections are usually hard to treat conservatively due the resistance and tolerance of pathogens conventional antimicrobial therapy. Bacterial colonization vascular grafts may lead life-threatening conditions such as sepsis. The objective this study is evaluate whether antibiotics bacteriophages can reliably prevent grafts. (2) Methods: Gram-positive Gram-negative were simulated on samples woven PET gelatin-impregnated using Staphylococcus aureus...
Prenatal ultrasound screening in the second trimester is widely used maternal health care. diagnosis and prenatal often exposed to several accusation, such as inducing unnecessary anxiety, carrying out a selection forcing pregnant women into attending screening. The aim of this study was investigate knowledge intention screening.This prospective study. Women 20 weeks anomaly scan were given an anonymous questionnaire evaluate background about their opinion screening.600 (96.7%) 620 recruited...
Background: Infection of vascular grafts is a life-threatening complication in cardiovascular surgical procedures. This experimental study tested the efficacy and possible harmful effects daptomycin pre-treatment vivo prevention graft infection caused by Staphylococcus aureus. Methods: Polyethylene terephthalate (PET) patches (5 × 7 mm) were sewn on infra-renal abdominal aorta 32 New Zealand White rabbits. Before implantation, either pre-treated for 15 min with one group (n = 13) or left...
Background: Surgical site infections remain a significant concern in cardiovascular surgery, particularly when they involve multidrug-resistant pathogens. Phages are an effective alternative or supplement to antibiotic therapy. Currently, retrospective cases of bacteriophage use surgery have been described. However, there is no systematization the obtained data, which complicates development evidence base. This study aims develop practical and clinically applicable methods predict...
Fibromuscular dysplasia is a non-inflammatory, non-atherosclerotic vascular disease, occurring predominantly in younger females. A histologically heterogeneous group of fibroplasia without an inflammatory component causes arterial narrowing. It affects mostly one or both renal arteries, cervicocranial visceral leading to hypertension, failure/renal infarction stroke/transient ischaemic attack. We present the case young female patient with abdominal aortic coarctation, history acute failure,...
Objectives: Surgical therapy of infective endocarditis (IE) is often a technically complex that depends on an adequate postoperative antibiotic to prevent early prosthetic valve infection. Conventional microbiological tests are negative due fastidious growth requirements or inhibition strains from antibiotic-treated patients. Moreover, cultural can take more than 1 week prior obtaining results. Direct molecular testing does not depend pathogens, but generate false-positive results because...
Objectives: Despite the observance of conditions asepsis and systemic prophylactic administration antibiotics, bacterial contamination implantable materials often occurs. For example, incidence vascular implant infections ranges from 1 to 6% cases, depending on location type an implant, which is associated with high morbidity mortality. Bacteriophages have been known for more than a hundred years their application good alternative or support standard antibacterial therapy. However adequate...
Background: Aortic graft infections are a major complication in cardiothoracic surgery leading to significantly increased mortality. The spreading of multi- or pan-resistant bacteria makes it necessary develop new strategies prevent and fight those prosthetic infections. Bacteriophages an effective alternative tool antibiotics. In our study we evaluated the possibility phage based prevention vascular