A5057682213- Cardiac electrophysiology and arrhythmias
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Ion channel regulation and function
- Receptor Mechanisms and Signaling
- Cardiac pacing and defibrillation studies
- Anodic Oxide Films and Nanostructures
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes Treatment and Management
- SARS-CoV-2 and COVID-19 Research
- Pancreatic function and diabetes
- Foreign Body Medical Cases
- Viral Infections and Immunology Research
- MicroRNA in disease regulation
- Bariatric Surgery and Outcomes
- Potassium and Related Disorders
- Healthcare Systems and Technology
- Laser Design and Applications
- Semiconductor materials and devices
- Lipoproteins and Cardiovascular Health
- Hydrogen embrittlement and corrosion behaviors in metals
- Biochemical and Structural Characterization
- Pharmaceutical studies and practices
- Renal Transplantation Outcomes and Treatments
- Ion Transport and Channel Regulation
University Hospital Heidelberg
2018-2024
Heidelberg University
2018-2024
German Centre for Cardiovascular Research
2019-2024
Institut Agronomique et Vétérinaire Hassan II
2023
University of Freiburg
2006
Kaiser Permanente Vacaville Medical Center
1998
Abstract In recent years, SGLT2 inhibitors have become an integral part of heart failure therapy, and several mechanisms contributing to cardiorenal protection been identified. this study, we place special emphasis on the atria investigate acute electrophysiological effects dapagliflozin assess antiarrhythmic potential inhibitors. Direct were investigated in patch clamp experiments isolated atrial cardiomyocytes. Acute treatment with elevated-dose caused a significant reduction action...
Abstract Aims TASK-1 (K2P3.1) two-pore-domain potassium channels are atrial-specific and significantly up-regulated in atrial fibrillation (AF) patients, contributing to AF-related electrical remodelling. Inhibition of cardiomyocytes AF patients was shown counteract action potential duration shortening. Doxapram identified as a potent inhibitor the channel. In this study, we investigated antiarrhythmic efficacy doxapram porcine model AF. Methods results successfully cardioverted pigs with...
Background Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. However, underlying molecular mechanisms are insufficiently understood. Previous studies suggested that microRNA (miRNA) dependent gene regulation plays an important role in initiation and maintenance of AF. The 2-pore-domain potassium channel TASK-1 (tandem P domains a weak inward rectifying K+ channel-related acid sensitive 1) atrial-specific ion upregulated Inhibition current prolongs atrial action...
Background The tandem of P domains in a weak inward rectifying K+ channel (TWIK)-related acid-sensitive (TASK-1; hK2P3.1) two-pore-domain potassium was recently shown to regulate the atrial action potential duration. In human heart, TASK-1 channels are specifically expressed atria. Furthermore, upregulation currents described patients suffering from fibrillation (AF). We therefore hypothesized that represent an ideal target for antiarrhythmic therapy AF. present study, we tested effects...
Background Upregulation of the two-pore-domain potassium channel TASK-1 (hK 2 P 3.1) was recently described in patients suffering from atrial fibrillation (AF) and resulted shortening action potential. In human heart, channels facilitate repolarization are specifically expressed atria. present study, we tested antiarrhythmic effects experimental ion inhibitor A293 that is highly affine for a porcine large animal model persistent AF. Methods Persistent AF induced German landrace pigs by right...
Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and one of major causes cardiovascular morbidity mortality. Despite good progress within past years, safe effective treatment AF remains an unmet clinical need. The anti-anginal agent ranolazine has been shown to exhibit antiarrhythmic properties via mainly late INa IKr blockade. This results in prolongation atrial action potential duration (APD) refractory period (ERP) with lower effect on ventricular...
The two-pore-domain potassium channel TASK-1 regulates atrial action potential duration. Due to the atrium-specific expression of in human heart and functional upregulation currents fibrillation (AF), represents a promising target for treatment AF. Therefore, detailed knowledge molecular determinants inhibition may help identify new drugs future therapy In current study, by potent antiarrhythmic compound A293 (AVE1231) were studied detail.Alanine-scanning mutagenesis together with...
Natural bioactive compounds are of general interest for pharmaceutical research because they may serve as leads in drug development campaigns. Among them, microginins linear peptides known to inhibit various exopeptidases. The crystal structure microginin FR1 from Microcystis sp. bound bovine lens leucine aminopeptidase was established at 1.73 Å resolution. observed binding could be beneficial the design potent inhibitors.
Mechanosensitive hTREK-1 two-pore-domain potassium (hK2P2.1) channels give rise to background currents that control cellular excitability. Recently, TREK-1 have been linked the regulation of cardiac rhythm as well hypertrophy and fibrosis. Even though pharmacological biophysical characteristics widely studied, relatively little is known about their posttranslational modifications. This study aimed evaluate whether are N-glycosylated glycosylation may affect channel functionality. Following...
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been linked to cardiovascular complications, notably cardiac arrhythmias. The open reading frame (ORF) 3a of the genome encodes for a transmembrane protein that can function as an ion channel. aim this study was investigate role SARS-CoV-2 ORF in COVID-19-associated arrhythmias and its potential pharmacological target.
Two pore-domain potassium (K 2P ) channels mediate background currents that stabilize the resting membrane potential and facilitate action repolarization. In human heart, hK 17.1 are predominantly expressed in atria Purkinje cells. Reduced atrial protein levels were described patients with fibrillation or heart failure. Genetic alterations associated cardiac conduction disorders. Little is known about posttranslational modifications of 17.1. Here, we characterized glycosylation investigated...
Background Electrocardiographic (ECG) features of left bundle branch (LBB) block (LBBB) can be observed in up to 20%–30% patients suffering from heart failure with reduced ejection fraction. However, predicting which LBBB will benefit cardiac resynchronization therapy (CRT) or conduction system pacing remains challenging. This study aimed establish a translational model enhance our understanding its pathophysiology and improve therapeutic approaches. Methods Fourteen male pigs underwent...
Abstract Funding Acknowledgements Type of funding sources: Private company. Main source(s): Medtronic Background and Objective ECG features left bundle branch (LBB) block (LBBB) can be observed in up to 20–30 % patients that suffer from heart failure with reduced ejection fraction. The resulting mechanical intraventricular asynchrony contributes the worsening ventricular hemodynamics has a relevant impact on prognosis affected patients. fact we still cannot accurately predict which LBBB will...
Non-vitamin K antagonist oral anticoagulants (NOACs) are widely used in the prevention of stroke and systemic embolism patients with non-valvular atrial fibrillation (AF). The efficacy NOACs has been attributed part to pleiotropic effects that mediated through on thrombin, factor Xa, their respective receptors. Direct pharmacological cardiac ion channels have not addressed date. We hypothesized favourable clinical outcome NOAC use may be associated previously unrecognized repolarizing...
Abstract Background Recently, inhibitors of sodium-glucose transporter 2 (SGLT2i) were shown to have tremendous cardioprotective effects in patients with type diabetes mellitus (T2DM) as well heart failure (HF) patients, regardless their glycemic status. Among other beneficial on cardiovascular outcome an antiarrhythmic effect SGLT2i was indicated. In T2DM therapy associated a significantly reduced risk atrial arrhythmias and sudden cardiac death. As (SGLT2) is not expressed within the...
Background: Atrial fibrillation (AF) is the most clinically relevant atrial arrhythmia in horses.Atrial equine athletes can have an impact on performance and horse rider safety.Transvenous electrical cardioversion becomes treatment of choice but requires special equipment expertise.The commonly used drug for quinidine sulfate side effect be considerable product more difficult to obtain.Recurrence rates AF are relatively high little known about drugs that might reduce recurrence.Therefore, it...
myocardial wall and higher blood flow of horses, it is unknown if settings used in human medicine can be extrapolated to horses.Objectives: To determine optimal safe ablation for the equine heart. Study design: In vitro experiments.Methods: Strips atrial ventricular tissue from hearts were suspended a bath with isotonic saline at 37 C.Flow was created by pump velocity level set 0.35 m/s, based on vena cava caudalis measurements horses.The catheter mounted holder dynamometer maintain tip...