A5031356291- Proteoglycans and glycosaminoglycans research
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Protease and Inhibitor Mechanisms
- Cell Adhesion Molecules Research
- SARS-CoV-2 and COVID-19 Research
- Radioactive contamination and transfer
- Risk Perception and Management
- Disaster Response and Management
- Glycosylation and Glycoproteins Research
- Mercury impact and mitigation studies
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Metal complexes synthesis and properties
- Biomarkers in Disease Mechanisms
- Blood Coagulation and Thrombosis Mechanisms
- Disaster Management and Resilience
- Psychosocial Factors Impacting Youth
- Genomics, phytochemicals, and oxidative stress
- Organometallic Compounds Synthesis and Characterization
- Nitric Oxide and Endothelin Effects
- Heavy metals in environment
- Fibroblast Growth Factor Research
- Sulfur Compounds in Biology
- Connective tissue disorders research
Fukushima Medical University
2021-2025
Toho University
2016-2025
Tokyo University of Science
2013-2024
National Kyushu Medical Center
2011-2024
Clinical Research Institute
2011-2024
Kobe University
2023
Tokushima Red Cross Hospital
2021-2022
Chiba University
2022
Osaka University
2021
Nagoya Bunri University
2009-2020
This was a retrospective cohort study, which aimed to investigate the factors associated with hesitancy receive third dose of coronavirus disease 2019 (COVID-19) vaccine. A paper-based questionnaire survey administered all participants. study included participants who provided answers in about whether they had an intent Data on sex, age, area residence, adverse reactions after second vaccination, vaccination desired, and reasons accept or hesitate over booster were retrieved. Among 2439...
In the mechanically active environment of artery, cells sense mechanical stimuli and regulate extracellular matrix structure. this study, we explored changes in synthesis proteoglycans by vascular smooth muscle response to precisely controlled strains. Strain increased mRNA for versican (3.2-fold), biglycan (2.0-fold), perlecan whereas decorin levels decreased a third control levels. also versican, biglycan, core proteins, with concomitant decrease protein. Deformation did not alter...
This was a retrospective cohort study, which aimed to investigate the factors associated with hesitancy receive third dose of coronavirus disease 2019 (COVID-19) vaccine. A paper-based questionnaire survey administered all participants. Accordingly, study included participants who provided answer in whether they have an intent Data on sex, age, area residence, adverse reactions after second vaccination, vaccination desired, and reasons accept or hesitate booster were retrieved. Among 2439...
The health of the vulnerable populations receiving Long-Term Care (LTC) Insurance Programs was threatened by direct and indirect effects disasters. 2011 Great East Japan Earthquake Tsunami explosion at Fukushima Daiichi nuclear power plant (FDNPP) forced 164,865 people's evacuation caused many disaster-related deaths. We examined relationship between these deaths LTC certification. Data were collected from 520 people who living in Minamisoma City during earthquake whose certified as...
Introduction The health of patients with mental disorders, such as alcohol-related diseases, often deteriorates after disasters. However, the causes death among those diseases during and radiation disasters remain unclear. Methods To minimize prevent deaths in future disasters, we analyzed summarized six cases Minamisoma City, a municipality near Fukushima Daiichi nuclear power plant. Results Patients were generally treated for diseases. In one case, patient was forced to evacuate because...
Abstract The medical situation during disasters often differs from that at usual times. Disasters can lead to significant mortality be difficult monitor. types of disaster-related deaths are largely unknown. In this study, we conducted a survey categorize the caused by radiation disaster. A total 520 people living in Minamisoma City, Fukushima Prefecture, time Daiichi Nuclear Power Plant accident, who were certified have died due causes surveyed. We divided participants into those home...
The regulation of vascular endothelial cell behavior during angiogenesis and in disease by transforming growth factor-β<sub>1</sub>(TGF-β<sub>1</sub>) is complex, but it clearly involves factor-induced changes extracellular matrix synthesis. Proteoglycans (PGs) synthesized cells contribute to the formation also influence cellular proliferation migration. Since effects TGF-β<sub>1</sub>on smooth muscle are dependent on density, possible that TGF-β<sub>1</sub> directs different patterns PG...
Lead, a ubiquitous heavy metal, is an important industrial and environmental pollutant that can target the vascular endothelium. To clarify effects of lead on unfolded protein response (UPR) their significance in cytotoxicity, we examined expression function endoplasmic reticulum (ER) chaperones glucose-regulated 78 (GRP78) 94 (GRP94) endothelial cells. We used bovine aortic cells as vitro model Exposure to nitrate resulted marked induction GRP78 GRP94 messenger RNA levels. In lead, proteins...
Fat mass obesity-associated protein (FTO) is a DNA/RNA demethylase involved in the epigenetic regulation of various genes and considered therapeutic target for obesity, cancer, neurological disorders. Here, we aimed to design novel FTO-selective inhibitors by merging fragments previously reported FTO inhibitors. Among synthesized analogues, compound 11b, which merges key Hz (3) MA (4), inhibited selectively over alkylation repair homologue 5 (ALKBH5), another demethylase. Treatment acute...
Background/Objectives: Limited research has compared tests assessing humoral and cellular immunity related to SARS-CoV-2 infection. This study evaluated immunoglobulin G for nucleocapsid (IgG(N)) T-spot (T-spot(N)) assays against polymerase chain reaction (PCR) test results identifying infected individuals. Methods: included participants who had completed five blood samplings since their second COVID-19 vaccination between 9 September 2021 6 November 2022. Chemiluminescent immunoassay (CLIA)...
Abstract A key issue in the post-COVID-19 era is ongoing administration of COVID-19 vaccines. Repeated vaccination essential for preparing against currently circulating and newly emerging SARS-CoV-2 variants while enabling people to continue with daily life. Optimizing strategies crucial efficiently manage medical resources establish an effective framework. Therefore, it important quantitatively understand vaccine-induced immunity dynamics be able identify poor responders lower sustained...
Methylmercury is the causative organometallic compound of Minamata disease. Pathological changes in cerebrum patients are localized along deep sulci and fissures cerebral cortex such as calcarine fissure. It has been suggested that occurrence brain edema important for damage caused by methylmercury. Previously, we found methylmercury induces vascular endothelial growth factor-A cultured human microvascular pericytes, which may increase permeability microvasculature. In present study, our...
Metallothionein (MT) plays a central role in cellular defense against heavy metals and oxidative stress. Since the induction of MT requires activation metal response element (MRE)-binding transcription factor-1 (MTF-1) by binding zinc ions, inorganic is regarded as typical inducer. However, previous report, we showed that could not induce vascular endothelial cells. While it suggested presents mechanisms different from those other cell types, these remain unclear. In this study, investigated...
The interest in organic–inorganic hybrid molecules as molecular probes for biological systems has been growing rapidly. Such exhibit unique activities. Herein, copper(II) bis(diethyldithiocarbamate) (Cu10) was found to activate the transcription factor NF-E2-related 2 (Nrf2), which is responsible regulating antioxidant and phase II xenobiotic enzymes, vascular endothelial cells. copper complex rapidly accumulated within cells induced nuclear translocation of Nrf2, leading upregulation...
Proteoglycans are macromolecules that consist of a core protein and one or more glycosaminoglycan side chains. A small leucine-rich dermatan sulfate proteoglycan, biglycan, is the predominant types proteoglycans synthesized by vascular endothelial cells; however, physiological functions biglycan not completely understood. In present study, bovine aortic cells in culture were transfected with interfering RNAs for expression other was examined. Transforming growth factor-β1 signaling also...
The objective of this study was to clarify the impact adverse reactions on immune dynamics. We investigated pattern systemic after second and third coronavirus disease 2019 (COVID-19) vaccinations their relationship with immunoglobulin G against severe acute respiratory syndrome 2 spike 1 protein titers, neutralizing antibody levels, peak cellular responses, rate decrease vaccination in a large-scale community-based cohort Japan. Participants who received BNT162b2 (Pfizer/BioNTech) or...
Organic-inorganic hybrid molecules, which are composed of an organic structure and metal(s), indispensable for synthetic chemical reactions; however, their toxicity has been incompletely understood. In the present study, we discovered two cytotoxic organobismuth compounds whose cytotoxicity diminished upon replacement intramolecular bismuth atom with antimony atom. The intracellular accumulation was much higher than that organoantimony corresponding structures. We also showed both required...