A5045941121- Oral microbiology and periodontitis research
- Thin-Film Transistor Technologies
- Cardiac electrophysiology and arrhythmias
- Cardiomyopathy and Myosin Studies
- Ion Channels and Receptors
- Streptococcal Infections and Treatments
- Meat and Animal Product Quality
- Cardiovascular Effects of Exercise
- Polyomavirus and related diseases
- Inflammasome and immune disorders
- Silicon and Solar Cell Technologies
- Plant Virus Research Studies
- Cardiac Ischemia and Reperfusion
- Cytokine Signaling Pathways and Interactions
- Magneto-Optical Properties and Applications
- Neuroscience and Neural Engineering
- Infective Endocarditis Diagnosis and Management
- Semiconductor materials and devices
- Erythrocyte Function and Pathophysiology
- Photodynamic Therapy Research Studies
- Exercise and Physiological Responses
- RNA Interference and Gene Delivery
- Hemoglobinopathies and Related Disorders
- Advancements in Semiconductor Devices and Circuit Design
- Pluripotent Stem Cells Research
Nagoya City University
2023-2024
Asahikawa Medical University
2021-2024
Nippon Dental University
2023-2024
Okayama University
2014-2022
University of Freiburg
2021
Universitäts-Herzzentrum Freiburg-Bad Krozingen
2021
Asahikawa University
2020
Nihon University
2014-2019
Japan Display (Japan)
2018
Tokyo Women's Medical University
2014-2016
Porphyromonas gingivalis has been shown to accelerate atherosclerotic lesion development in hyperlipidemic animals. Atherosclerosis is a disease characterized by inflammation of the arterial wall. Recent studies have suggested that NLRP3 inflammasome plays an important role vascular and atherosclerosis. Herein, we investigated possible association between atherosclerosis periodontal induced P. infection using apolipoprotein E-deficient, spontaneously (Apoeshl) mice. Oral with wild-type (WT)...
This study aimed to assess the impact of different laser irradiation modes and photosensitizer types on bactericidal efficacy antimicrobial photodynamic therapy (aPDT). Dentin plates were prepared by sectioning crown dentin bovine teeth infected with Streptococcus sobrinus (n = 11). Nine aPDTs involving combination three 1% solutions photosensitizers (brilliant blue, BB; acid red, AR; methylene MB) semiconductor lasers (50 mW for 120 s, 100 60 200 30 s) performed each plate, control...
Ischemic heart disease still remains the most common cause of cardiac death. During ischemia-reperfusion (I/R), reactive oxygen species (ROS) are produced in excess tissue, where they induce cell Our previous study showed that 9-phenanthrol (9-Phe), a specific inhibitor TRPM4 channel, preserves contractile function and protects from I/R injury-related infarction excised rat heart. Accordingly, we hypothesized channels involved 9-Phe-mediated cardioprotection against ROS-induced injury. In...
Abstract Baroreflex control of cardiac contraction (positive inotropy) through sympathetic nerve activation is important for cardiocirculatory homeostasis. Transient receptor potential canonical subfamily (TRPC) channels are responsible α 1 -adrenoceptor (α AR)-stimulated cation entry and their upregulation associated with pathological remodeling. Whether TRPC participate in physiological pump functions remains unclear. We demonstrate that TRPC6-specific Zn 2+ influx potentiates...
When a cardiac muscle is held in stretched position, its [Ca2+] transient increases slowly over several minutes process known as stress-induced slow increase intracellular Ca2+ concentration ([Ca2+]i) (SSC). Transient receptor potential canonical (TRPC) 3 forms non-selective cation channel regulated by the angiotensin II type 1 (AT1R). In this study, we investigated role of TRPC3 SSC. Isolated mouse ventricular myocytes were electrically stimulated and subjected to sustained stretch. An AT1R...
In this letter, a magnetic-field area sensor using poly-Si micro Hall devices is reported. A matrix array of formed on glass substrate fabrication processes compatible with thin-film transistors. Here, 3 × are arrayed every 1 mm, and the dimension principal part less than 50 μm. compensation technique characteristic variation used, it confirmed that sensing correctly conducted. This presents novel application technologies for giant-micro flexible electronics.
The function of the A element (nucleotides 5107 to 5130) polyomavirus enhancer is augumented in NIH 3T3 cells by a tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate (TPA). One its targets an AP1 consensus sequence motif recognized nuclear factor, PEBP1. In Ha-ras-transformed cells, however, was not enhanced TPA treatment, and at same time PEBP1 detected extract mobility shift assay. either from treated vivo with protein kinase inhibitor, staurosporine, or after treatment...
Hall voltage in micro poly-Si cells is evaluated to analyze the effect films and investigate possibility of magnetic sensors. Normal occurs, but has an offset even when field zero, whereas change proportional field. The caused by control current flows through zigzag paths due random location polycrystalline grains. These results mean that material evaluation based on also available for suggest area
We have reported recently that small T antigen of polyomavirus stimulates the growth NIH 3T3 cells beyond their saturation density and induces weak anchorage-independent (T. Noda, M. Satake, T. Robins, Y. Ito, J. Virol. 60:105-113, 1986). examined whether would cooperate with middle in vitro transformation (fibroblasts) NRK-52E (epitheliallike) cells. The small-T-antigen gene, when cotransfected middle-T-antigen had no additional effect on efficiency or size dense foci formation induced by...
The Hall effects in micro poly-Si devices with lightly- and heavily-doped n- p-type channels are analyzed. Although the voltage (VH) has an offset (VO) even when magnetic field (B) is zero, a normal VH occurs its change proportional to B. Lightly-doped n-type exhibit highest sensitivity. Moreover, polarities of B control current (I) reversed investigated. VO originates from zigzag paths I. results indicate that films can be evaluated based on effect suggest possibility area sensors.
Hereditary Xerocytosis, a rare hemolytic anemia, is due to gain of function mutations in PIEZO1, non-selective cation channel activated by mechanical stress. How these PIEZO1 impair and alter red blood cell (RBC) physiology, not completely understood. Here, we report the characterization N-terminal part protein (V598M, F681S double mutation G782S/R808Q), that was subject many investigations decipher its role gating. Our data show electrophysiological features mutants expressed HEK293T cells...
Plastic film IPS‐LCDs were fabricated with transparent polyimide (PI) substrates. Conventional PI substrates have a large coefficient of thermal expansion and cause high retardation in thickness direction. We developed new fabrication process sheet design that improves upon these characteristics.