A5070896607- Immune cells in cancer
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Pediatric Hepatobiliary Diseases and Treatments
- Organ Transplantation Techniques and Outcomes
- Liver Disease Diagnosis and Treatment
- Congenital Anomalies and Fetal Surgery
- Liver Disease and Transplantation
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Photodynamic Therapy Research Studies
- Hepatitis C virus research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- Immune Cell Function and Interaction
- Dental Research and COVID-19
- Gallbladder and Bile Duct Disorders
- Immune Response and Inflammation
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Renal Transplantation Outcomes and Treatments
- Dental Erosion and Treatment
- Liver physiology and pathology
- Endoplasmic Reticulum Stress and Disease
- Sepsis Diagnosis and Treatment
Kumamoto University Hospital
2023-2025
Kumamoto University
2014-2024
Nippon Dental University
2020-2024
Abstract Recruitment of bone marrow derived monocytes via bloodstream and their subsequent conversion to CX3CR1 + macrophages in response intestinal injury is dependent on CCR2, Nr4a1, the microbiome. This process critical for proper tissue repair; however, GATA6 peritoneal cavity might represent an alternative, more readily available source mature functional myeloid cells at damaged locations. Here we show, using spinning-disk confocal microscopy, that large F4/80 hi promptly accumulate...
This study aimed to assess the impact of different laser irradiation modes and photosensitizer types on bactericidal efficacy antimicrobial photodynamic therapy (aPDT). Dentin plates were prepared by sectioning crown dentin bovine teeth infected with Streptococcus sobrinus (n = 11). Nine aPDTs involving combination three 1% solutions photosensitizers (brilliant blue, BB; acid red, AR; methylene MB) semiconductor lasers (50 mW for 120 s, 100 60 200 30 s) performed each plate, control...
<title>Abstract</title> Primary central nervous system lymphoma (PCNSL) often presents with nonspecific cognitive decline and neuropsychiatric changes at onset, yet the underlying mechanisms remain poorly understood. Polyglutamylation, a posttranslational modification, is associated better responses to methotrexate-based chemotherapy in patients PCNSL. On other hand, hyperglutamylation of microtubules neurons has been implicated neurodegeneration via accumulation phosphorylated tau. This...
Abstract Neutrophils are considered responsible for the pathophysiological changes resulting from hepatic ischemia-reperfusion (I/R) injury, which is a complication of trauma, shock, liver resection, and transplantation. Recently, evidence accumulating that formyl-peptide receptor (FPR) signaling constitutes an important danger signal guides neutrophils to sites inflammation. This study aimed investigate dynamic neutrophil recruitment using two-photon laser-scanning microscopy (TPLSM) in...
ABO-incompatible (ABOi) living donor liver transplantation (LDLT) has been performed to compensate for shortage. To date, few studies have reported detailed B-cell desensitization protocols and long-term outcomes of ABOi pediatric LDLT.
Liver transplantation (LT) is considered the standard treatment for end-stage liver disease, but ideal donors remain in limited supply, resulting an unavoidable increase need to use grafts from marginal donors. The attenuation of ischemia-reperfusion injury (IRI) such therefore crucial reducing possibility primary non-function and graft loss. Some reports have found that molecular-hydrogen showed antioxidant anti-inflammatory effects preventing IRI some non-hepatic transplant models....
Blood levels of acute-phase protein α1-acid glycoprotein (AGP, orosmucoid) increase in patients with cancer. Although AGP is produced from hepatocytes following stimulation by immune cell-derived cytokines under conditions inflammation and tumorigenesis, the functions tumorigenesis tumor progression remain unknown. In present study, we revealed that contributes directly to development induction programmed death ligand 1 (PD-L1) expression IL6 production macrophages. Stimulation induced PD-L1...
Tumor‐associated calcium signal transducer 2 (TROP2) is a cell‐surface glycoprotein involved in the high malignant potential of several cancers. Antibody‐drug conjugates that target TROP2 represent promising approach for treatment TROP2‐expressing cancers including lung cancer and breast cancer. expression was tested by immunohistochemistry adenocarcinoma (ADC) squamous cell carcinoma samples, its correlation with clinicopathological factors, survival rate p53 mutation, statistically...
Abstract Hepatoblastoma is the most common pediatric liver tumor, but little research has been done on role of macrophages in hepatoblastoma. The purpose this study was to gain insight into potential roles for Paraffin‐embedded specimens from 56 patients who underwent surgical resection were examined with immunohistochemical staining macrophage‐specific markers, Iba1 and CD163. Significant differences seen among histological subtypes. Significantly increased numbers detected embryonal...
Although pituitary neuroendocrine tumors (PitNETs) are usually benign, some highly invasive and recurrent. Recurrent PitNETs often treatment-resistant there is currently no effective evidence-based treatment. Tumor-associated macrophages (TAMs) promote tumor growth in many cancers, but the effect of TAMs on remains unclear. This study investigated role incidence recurrent PitNETs. Immunohistochemical analysis revealed that densities CD163- CD204-positive tended to increase Compared with...
Living donor liver transplantation (LDLT) for patients with portal vein thrombosis (PVT) is associated several technical challenges its complicated procedures and poor outcomes. Some institutions still consider preexisting PVT as a relatively contraindication LDLT.Between April 2010 May 2016, 129 adults underwent LDLT at our institution, 28 (21.7%) of whom had PVT. Portal was diagnosed using preoperative imaging techniques intraoperative findings. The characteristics outcomes the cases were...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic disorders associated with metabolic syndrome, and its prevalence has been on rise. The pathogenesis NAFLD not yet sufficiently elucidated due to multifactorial nature disease, although activation macrophages/Kupffer cells considered be involved. We previously reported an animal model using MicrominipigsTM (µMPs) fed high-fat diets containing cholesterol or without cholic acid. aim this study was investigate...
Septic (or endotoxin) shock is a severe systemic inflammatory disease caused by bacteraemia or endotoxaemia. Although it known that increased serum levels of CD163 are observed in septic/endotoxin patients, the exact function and significance macrophage activation remain unclear. Therefore, current study, we tested whether contributes to pathogenesis endotoxin mice.In samples obtained from autopsy, number CD163-positive macrophages was kidney, liver, heart, bone marrow spleen patients who...