A5102979514- High Temperature Alloys and Creep
- Microstructure and Mechanical Properties of Steels
- Microstructure and mechanical properties
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Glycosylation and Glycoproteins Research
- Metallurgy and Material Forming
- Gastrointestinal disorders and treatments
- Monoclonal and Polyclonal Antibodies Research
- Aluminum Alloy Microstructure Properties
- Pancreatic and Hepatic Oncology Research
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Esophageal and GI Pathology
- Pancreatitis Pathology and Treatment
- Cardiac Imaging and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- Fatigue and fracture mechanics
- Cardiac electrophysiology and arrhythmias
- Growth Hormone and Insulin-like Growth Factors
- Cardiac Ischemia and Reperfusion
- Clinical Nutrition and Gastroenterology
- Fire effects on concrete materials
Keiyukai Sapporo Hospital
2011-2024
Hokkaido hospital
2021
Osaka University
2018
Tohoku Gakuin University
2014-2018
Osaka Women's and Children's Hospital
2018
Sapporo Medical University
2001-2015
Mitsubishi Electric (Japan)
2011
Yokohama National University
1996-2006
Tokyo Medical and Dental University
2005
Toho University
2005
This study was performed to examine the usefulness of medical endoscopic imaging utilizing narrow-band illumination. The contrast between vascular pattern and adjacent mucosa underside human tongue measured using five illuminations three broadband illuminations. results demonstrate that pathological features a are dependent on center wavelength bandwidth By illumination 415±30 nm, capillary in superficial layer markedly improved. is an important benefit difficult obtain with ordinary...
BNIP3 protein is a proapoptotic member of the Bcl-2 family that expressed in hypoxic regions tumors. To examine its role progression gastrointestinal cancer, we examined expression and DNA methylation status gene panel colorectal gastric cancer cell lines. was not 14 24 lines tested, absence caused by mutation or altered hypoxia inducible factor-1, key transcription factor regulates expression. On other hand, 5' CpG island closely correlated with silencing gene. Moreover, treating methylated...
The active vibration suppression with this type of variable-stiffness member is shown to be always stable. A theoretical investigation on a single-degree-of-freedom system shows potential high efficiency for due its unique hysteretic characteristics
Many tumor types including that of the ovary show loss heterozygosity (LOH) on chromosome arm 7q, which suggests existence at least one suppressor gene (TSG) this arm. We have studied region surrounding putative CUTL1 7q22 in 127 epithelial ovarian tumors. LOH was found across 31% malignant and 14% benign In 16% tumors appeared to be centered gene. This has been implicated previously as a TSG both uterine leiomyomas breast carcinoma. However, mutation analysis 47 with failed identify any...
New hybrid hydrogels with nanogel domains were obtained by using polymerizable self-assembled nanogels as cross-linkers. Methacryloyl groups introduced to cholesteryl group-bearing pullulan (CHP). The methacryloyl CHPs (CHPMAs) formed their self-association in water (Rg = 14−17 nm). CHPMA polymerized 2-methacryloyloxyethyl phosphorylcholine (MPC) radical polymerization a semidilute aqueous solution. acted effective cross-linkers for gelation. TEM observation showed that the structure was...
Abstract Summary: Polymerizable nanogels were prepared by self‐assembly of cholesteryl group‐bearing pullulan (CHP) with methacryloyl groups (CHPMA). The CHPMA nanogel was polymerized 2‐methacryloyloxyethyl phosphorylcholine (MPC) radical polymerization in dilute aqueous solution. solution properties the polymers water investigated TEM, SEC‐MALS, and fluorescence quenching technique. Monodispersed hybrid CHPMA‐MPC (CM nanogels) (25–30 nm radius gyration) obtained using as a seed‐nanogel. CM...
To examine the long term survival of geriatric patients treated with percutaneous endoscopic gastrostomy (PEG) in Japan.We retrospectively included 46 Japanese community and tertiary hospitals to investigate 931 consecutive (≥ 65 years old) swallowing difficulty newly performed PEG between Jan 1st 2005 Dec 31st 2008. We set death as an outcome explored associations among patient's characteristics at using log-rank tests Cox proportional hazard models.Nine hundred thirty one were followed up...
Abstract The mRNA expression levels of DCC gene, which is cloned from the deleted region chromosome 18q in colorectal cancers and thought to be a tumor‐suppressor was evaluated tissue specimens surgically resected patients with cancer by RT‐PCR. This method chosen as level below detectable for Northern‐blot analysis. Semi‐quantitative measurements were performed based on standard curve defined serial dilution cDNA. As result, found lower 17 out 30 than adjacent non‐cancerous tissues....
Abstract Purpose: The aim of this study was to characterize the relationship insulin-like growth factor (IGF)-II expression with IGF-I, IGF-I receptor (IGF-IR), cyclooxygenase-2 (COX-2), and matrix metalloproteinase (MMP)-7 in early colorectal carcinogenesis. Experimental Design: With semiquantitative reverse transcriptase-PCR, 90 human tumor tissues (63 adenomas 27 submucosal pT1 cancers) were analyzed for IGF-II, IGF-IR, COX-2, MMP-7 expression. Ninety-nine adenoma 60 cancer also...
Abstract BACKGROUND: Insulin‐like growth factor (IGF)‐I receptor (IGF‐IR) signaling is required for tumorigenicity and tumor progression of gastrointestinal cancers. The authors previously reported the success therapy cancers using adenoviruses that expressed dominant‐negative IGF‐IR (IGF‐IR/dn). In addition, it has been demonstrated affects vascular endothelial (VEGF) expression in some other types tumors. objective current study was to evaluate this interaction by studying roles...
It is generally accepted that most colorectal carcinomas arise in pre-existing adenomas. Morphologically, adenomas can be divided into two groups, protruded type and flat type. The aim of this study was to clarify relevant alterations gene expression associated with the early stage carcinogenesis. Using cDNA array, we analysed profiles 550 cancer-related genes 36 (18 flat-type 18 protruded-type adenomas) 14 invasive carcinomas. Among genes, chose 32 average levels which were at least...