A5035998238- Pharmacological Effects of Natural Compounds
- Plant-based Medicinal Research
- Ginseng Biological Effects and Applications
- Phytochemistry and biological activity of medicinal plants
- Traditional Chinese Medicine Analysis
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Hormonal Regulation and Hypertension
- Dermatology and Skin Diseases
- Ginger and Zingiberaceae research
- Herbal Medicine Research Studies
- Cancer Treatment and Pharmacology
- Natural Products and Biological Research
- Flavonoids in Medical Research
- Phytochemistry and Bioactive Compounds
- Medicinal Plants and Bioactive Compounds
- Oral microbiology and periodontitis research
- Medicinal plant effects and applications
- Food Quality and Safety Studies
- Mycobacterium research and diagnosis
- Adrenal Hormones and Disorders
- Allergic Rhinitis and Sensitization
- Drug-Induced Hepatotoxicity and Protection
- Medicinal Plant Extracts Effects
- Complementary and Alternative Medicine Studies
Nagoya City University
2016-2025
Pharmac
2009-2024
Shenyang Pharmaceutical University
2013
Hokkaido University
2005-2009
Science Club
2009
Kitasato University
2008
Hokkaido Pharmaceutical University
2001-2006
Kyoto University
1998-2005
University of Mississippi
2005
Kumamoto University
2002
Quercetin, a flavonol contained in various vegetables and herbal medicines, has biological activities including anti-cancer, anti-allergic anti-oxidative activities. However, low oral bioavailability of quercetin due to insolubility water limited its use as food additive or dietary supplement. Since the solubility is enhanced by glycosyl conjugation, present study, we evaluated several glycosides with different sugar moieties rats. quercetin-3-O-rutinoside (rutin), quercetin-3-O-glucoside...
The leaves of Perilla frutescens Britton (Labiatae) are one the most popular garnishes in Japan, used as an antidote for fi sh and crab meat allergy or a food colorant. present study was conducted to evaluate its anti-allergic effect identify active constituents using mice ear-passive cutaneous anaphylaxis (PCA)-reaction. 48 h after injection anti-ovalbumin serum into ears mice, ovalbumin evansblue dye were intravenously injected. extracted with boiling water, intraperitoneally injected 15...
ABSTRACT The antimycobacterial activities of disulfiram (DSF) and diethyldithiocarbamate (DDC) against multidrug- extensively drug-resistant tuberculosis (MDR/XDR-TB) clinical isolates were evaluated in vitro . Both DSF DDC exhibited potent antitubercular 42 M. , including MDR/XDR-TB strains. Moreover, showed remarkable bactericidal activity ex vivo Therefore, might be a drug repurposed for the treatment MDR/XDR-TB.
Perilla frutescens BRITTON (perilla, Labiatae) is a medicinal herb prescribed in Saiboku-to, which Kampo formula effective for allergic diseases such as bronchial asthma. The present study was conducted to evaluate the anti-allergic effect of orally administered perilla decoction and identify active constituents using mice ear-passive cutaneous anaphylaxis (PCA)-reaction, one animal models type I allergy. significantly suppressed PCA-reaction, inhibition % at dose 500 mg/kg 43%. contains...
The p53 tumor suppressor plays critical roles in cell cycle regulation and apoptotic death response to various cellular stresses, thereby preventing cancer development. Therefore, the activation of through small molecules is an attractive therapeutic strategy for treatment cancers retaining wild-type p53. We used a library 700 Myanmar wild plant extracts identify that induce transcriptional activity. A cell-based screening method with p53-responsive luciferase-reporter assay system revealed...
Kurarinone, a flavonoid isolated from the roots of Sophora flavescens, was suggested to exert potent antioxidant and immunosuppressive effects. However, underlying mechanisms remain unclear. Nuclear factor erythroid 2-related 2 (Nrf2) is key transcription that regulates defense system with anti-inflammatory activity. In present study, we demonstrated kurarinone activated Nrf2 increased expression enzymes, including heme oxygenase-1 (HO-1). Mechanistically, downregulated kelch-like...
Background: Esophageal squamous cell carcinoma (ESCC) is one of the most malignant cancers in world, which seriously affects survival and quality life patients. Aberrant expression microRNAs plays an important role occurrence progression cancer, while exosomes usually act as transmission intercellular substances (including miRNAs). The objective this study was to investigate relationship between exosomal miR-148a ESCC. Methods: Real Time-quantitative Polymerase Chain Reaction (qRT-PCR) used...
Polyporus Sclerotium botanically from the umbellatus (PERS.) FRIES, was traditionally used for purpose of promoting diuresis. The present study investigated diuretic effect ergosta-4,6,8(14),22-tetraen-3-one (ergone) which is a maker component according to chemical assay its quality standardization. It resulted in reversion ordinary value urinary ratio Na/K deoxycoricosterone acetate (DOCA)-treated and adrenalectomized rats, although it had no this on Na or K contents as well both normal...
Licorice (glycyrrhiza root) has been used as a herbal medicine worldwide with its main active constituent being glycyrrhizin (GL). sometimes causes adverse effects such inducing pseudoaldosteronism by inhibiting type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) caused glycyrrhetinic acid (GA), major metabolite of GL. In this study we compared the inhibitory GA, GL, and 3-monoglucuronyl-glycyrrhetinic (3MGA), another on 11β-HSD2 activity using microsomes rat kidney tissue slices. 3MGA, GL...
Kangen-karyu (KGK) is a herbal formula created under the theory of traditional Chinese medicine to invigorate blood and dispel stasis. It contains 6 herbs: peony root, cnidium rhizome, safflower, cyperus saussurea root (JP XIV), Salvia miltiorrhiza root. The present study has been conducted evaluate in vivo anti-thrombotic activity KGK using normal mice. Three consecutive days oral administration mice significantly extended tail-bleeding time suppressed ex platelet aggregation, while it did...
Hange-shashin-to (HST) has been used as an herbal formula to treat inflammatory ulcerative gut diseases complicated with psychoneurosis in Japanese traditional Kampo medicine. The aim of the present study is clarify anti-colitic effect HST using a model colitis induced by intracolonic instillation 2,4,6-trinitrobenzene sulfonic acid (TNBS) rats, and evaluate pharmaceutical properties its components. colonic damage was elucidated macroscopic scores, colon wet weight area mucosal necrosis....
3,4,5-trimethoxycinnamic acid (TMCA) is one of the constituents in Onji (roots Polygala tenuifolia WILLD), an herbal medicine used for sedative Japanese traditional Kampo medicine. Our previous study revealed that oral administration this compound prolongs sleeping time induced by hexobarbital mice to exhibit action. In present study, we investigate effects TMCA on stress with repeated cold exposure or intracerebroventricular injection corticotrophin-releasing hormone (CRH). Both types...
The pathway from β-carotene to astaxanthin is a crucial step in the synthesis of astaxanthin, red antioxidative ketocarotenoid that confers beneficial effects on human health. Two enzymes, ketolase (carotenoid 4,4′-oxygenase) and hydroxylase 3,3′-hydroxylase), are involved this pathway. Cyanobacteria known utilize carotenoid CrtW and/or CrtO, CrtR. Here, we compared catalytic functions ketolases, which originated Gloeobacter violaceus PCC 7421, Anabaena (also as Nostoc) sp. 7120 Nostoc...
Glycyrrhizin (GL) has been used to treat chronic hepatitis in Japan and Europe. It is thought induce pseudoaldosteronism via inhibition of type 2 11β-hydroxysteroid dehydrogenase (11β-HSD2) by glycyrrhetinic acid (GA), a major metabolite GL. A previous clinical study suggested that 3-monoglucuronyl-glycyrrhetinic (3MGA), another GL, might play more important role the pathogenesis pseudoaldosteronism. The present evaluates pharmacokinetics GL its metabolites rats with liver injury induced...
Gout is a common disease resulting from hyperuricemia which causes acute arthritis. Recently, genome-wide association studies revealed an between serum uric acid levels and variant of leucine-rich repeat-containing 16A (LRRC16A) gene. However, it remains to be clarified whether LRRC16A contributes the susceptibility gout. In this study, we investigated relationship rs742132 in A total 545 Japanese male gout cases 1,115 individuals as control group were genotyped. A/A genotype significantly...