A5066969749- Phytochemicals and Medicinal Plants
- Drug-Induced Hepatotoxicity and Protection
- Pharmacological Effects of Natural Compounds
- Phytochemistry and biological activity of medicinal plants
- Herbal Medicine Research Studies
- Natural product bioactivities and synthesis
- Bioactive Compounds and Antitumor Agents
- Natural Antidiabetic Agents Studies
- Curcumin's Biomedical Applications
- Computational Drug Discovery Methods
- Phytochemistry and Bioactive Compounds
- Genomics, phytochemicals, and oxidative stress
- Immune Response and Inflammation
- Tannin, Tannase and Anticancer Activities
- Cannabis and Cannabinoid Research
- Plant-derived Lignans Synthesis and Bioactivity
- SARS-CoV-2 and COVID-19 Research
- Oral microbiology and periodontitis research
- Ethnobotanical and Medicinal Plants Studies
- Ion Transport and Channel Regulation
- Pharmacological Effects of Medicinal Plants
- Ion channel regulation and function
- Carcinogens and Genotoxicity Assessment
- Plant-based Medicinal Research
- Pharmacogenetics and Drug Metabolism
University of Mississippi
2008-2024
Annamalai University
2024
St John's Hospital
2024
Weatherford College
2007
Nebraska Medical Center
2003
University of Nebraska Medical Center
2002
University of Madras
1995-2000
Immulina®, a commercial extract of Arthrospira (Spirulina) platensis is potent activator THP-1 monocytes and CD4+ T cells in vitro enhances several immunological functions mice. We further characterized Immulina® by determining that Braun-type lipoproteins are responsible for major portion the monocyte activation exhibited this material. In order to understand effect on NK cell activity, pilot study was conducted ten healthy North American individuals who supplemented their diet with (400...
Bioassay-guided fractionation of the leaves Eugenia rigida yielded three stilbenes, (Z)-3,4,3′,5′-tetramethoxystilbene (1), (E)-3,4,3′,5′-tetramethoxystilbene (2), and (E)-3,5,4′-trimethoxystilbene (3). Their structures were determined using 1D- 2D-NMR spectroscopy HRESIMS. The sterically hindered Z-stereoisomer 1, a new natural product, was prepared by time-dependent photoisomerization E-isomer (2) under UV irradiation at λ254 nm, while 2,3,5,7-tetramethoxyphenanthrene (5) identified λ365...
We previously reported that the majority of in vitro monocyte/macrophage activation exhibited by extracts Echinacea and other botanicals depends upon bacterial lipopolysaccharides Braun-type lipoproteins. determined contribution made these components to overall immune-enhancing activity detected E. purpurea angustifolia bulk root aerial material obtained from six major growers/suppliers North America. Substantial variation (up 200-fold) was observed materials when tested two cell lines. The...
This study aimed to examine if methanolic extracts of Pulsatilla vulgaris Mill. can inhibit HeLa cell proliferation through the modulation cancer-related signaling pathways. The cytotoxicity and chemical composition P. leaves root were also determined. Research showed that extract inhibited 12 pathways in a cervical cancer line most potent activation inhibition was observed for MYC, Notch, Wnt, E2F, Ets, Stat3, Smad, Hdghog, AP-1, NF-κB, at concentration 40 µg/mL. enhanced apoptotic death...
Machaeriols and machaeridiols are unique hexahydrodibenzopyran-type aralkyl phytocannabinoids isolated from Machaerium Pers. Earlier studies of machaeriol A (1) B (2) did not show any affinity for cannabinoid receptor 1 (CB1 or CNR1), although they structural analogs psychoactive hexahydrocannabinol. This study comprehensively reports on the affinities compounds, namely A-D (1-4) machaeridiol A-C (5-7), against CB2) opioid (κ, δ µ) receptors. Among D (4) (5-7) showed some selective binding...
We have identified potent monocyte/macrophage activating bacterial lipoproteins within commonly used immune enhancing botanicals such as Echinacea, American ginseng and alfalfa sprouts. The active were of the murein type origin since modified amino acid 2,3 dihydroxypropyl cysteine was detected using RP-HPLC. These in addition to lipopolysaccharide substantially more than other bacterially derived components when tested vitro activation systems. In experiments RAW 264.7 mouse peritoneal...
Abstract COVID-19 was declared an international public health emergency in January, and a pandemic March of 2020. There are over 23 million confirmed cases that have cause 800 thousand deaths worldwide as August 19th, is caused by the SARS-CoV-2 virus. presents surface “spike” protein binds to ACE2 receptor infect host cells. In addition respiratory tract, SARS-Cov-2 can also cells oral mucosa, which express receptor. The spike proteins highly glycosylated with sialic acid modifications...
The anticancer activities of Rubia cordifolia and its constituents have been reported earlier, but their influence on the crosstalk complex cancer-related signaling metabolic pathways (i.e., transcription factors; TF) has not yet fully investigated. In this study, R. root extract was subjected to cancer assay based bioactivity-guided fractionation, which yielded following compounds viz., three anthraquinones, namely alizarin (1), purpurin (2), emodin (3); two lignans, eudesmin (4) compound...
Since aerobic glycolysis was first observed in tumors almost a century ago by Otto Warburg, the field of cancer cell metabolism has sparked interest scientists around world as it might offer new avenues treatment for malignant cells. Our current study claims discovery gnetin H (GH) novel inhibitor that can decrease metabolic activity and lactic acid synthesis displays strong cytostatic effect melanoma glioblastoma Compared to most other inhibitors used combination with complex-1...
Aflatoxin B 1 (AFB 1) induced rat liver cancer is a well studied system of hepatocarcinogenesis. The present investigation aims at assessing the effect Semecarpus anacardium nut milk extract on AFB mediated hepatocellular carcinoma. This was administered orally (200 mg/kg body weight/day) for 14 days to hepatocarcinoma bearing rats. level lipid peroxides and antioxidant enzymes’ activity were determined in kidney homogenates. Marked increase peroxide levels concomitant decrease enzymic...