A5031537672- Bioactive Natural Diterpenoids Research
- Phytochemistry and Biological Activities
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Biological Activity of Diterpenoids and Biflavonoids
- Plant-based Medicinal Research
- Natural Antidiabetic Agents Studies
- Phytochemicals and Antioxidant Activities
- Plant biochemistry and biosynthesis
- Sesquiterpenes and Asteraceae Studies
- Traditional and Medicinal Uses of Annonaceae
- Phytochemistry and Bioactivity Studies
- Pharmacological Effects of Natural Compounds
- Toxin Mechanisms and Immunotoxins
- Berberine and alkaloids research
- Plant Toxicity and Pharmacological Properties
- Marine Sponges and Natural Products
- Plant Stress Responses and Tolerance
- Research on Leishmaniasis Studies
- Plant tissue culture and regeneration
- Garlic and Onion Studies
- Biological and pharmacological studies of plants
- Phytochemical Studies and Bioactivities
- Medicinal Plants and Neuroprotection
- Moringa oleifera research and applications
Isfahan University of Medical Sciences
2016-2025
University of Isfahan
2021-2025
Shahid Beheshti University of Medical Sciences
2011-2024
Shahid Beheshti University
2022
University of Mississippi
2018-2019
Shiraz University
2015-2017
Hairy roots induced by Agrobacterium rhizogenes are distinguished their high growth rate, genetic stability, and lateral branching. Datura metel is an important medicinal plant whose hairy used for the production of atropine, a tropane alkaloid applied as anticholinergic parasympathetic agent. To increase yield biotic (Bacillus cereus Staphylococcus aureus) abiotic (AgNO_3 nanosilver) elicitors were added to root cultures D. then analyzed through high-performance liquid chromatography. All...
Background. Dyslipidemia produces atherosclerosis, which in turn results coronary artery disease (CAD). Atherosclerosis is being considered as an inflammatory disease. Vaccinium arctostaphylos L. a plant with fruits rich anthocyanins. The aim of this study was to evaluate the effects fruit extract on serum levels lipids, hs-CRP, and malondialdehyde (MDA) marker oxidative stress, hyperlipidemic adult patients. Methods. In randomized, double-blind, placebo-controlled clinical trial, 50...
The decline in neurogenesis is a very critical problem Alzheimer disease. Different biological activities have been reported for medicinal application of quercetin. Herein, we investigated the potential quercetin rat model Alzheimer's disease induced by amyloid-beta injection. Rats were randomly divided into Control, + Saline and Quercetin groups. Following administration Amyloid-beta, rats group received 40 mg/kg/day orally one month. Our data demonstrated amyloid-β injection could impair...
Several factors lead to memory loss, the most important of which is brain aging that caused mostly by neuroinflammation and oxidative stress. The need finding preventive treatments impairment in elderly encouraged authors assess effect Acorus calamus on anxiety, antioxidant indices rat models.Different fractions A. were prepared. subject rats grouped 11 groups 10 each. In nine treated groups, extract gavage began 1 week before intraperitoneal (i.p.) injection lipopolysaccharide (LPS)...
Abstract Background T cell immunoglobulin and mucin-domain containing-3 (TIM-3) is a surface molecule that was first discovered on cells. However, recent studies revealed it also highly expressed in acute myeloid leukemia (AML) cells related to AML progression. As, Glutamine appears play prominent role malignant tumor progression, especially their group, therefore, this study we aimed evaluate the relation between TIM-3/Galectin-9 axis glutamine metabolism two types of lines, HL-60 THP-1....
ABSTRACT Efflux pumps and biofilm play significant roles in bacterial antibiotic resistance. This study investigates the potential of chlorogenic acid (CGA) carnosol (CL), as phenolic diterpene compounds, respectively, for their inhibitory effects on efflux pumps. Among 12 multidrug-resistant (MDR) strains Staphylococcus aureus Pseudomonas aeruginosa isolated from nosocomial skin infections, eight were identified extensively drug resistant (XDR) using disc diffusion method. The presence MDR...
A comparative study was carried out to explore the antiglycation potential and mechanisms of apigenin (AP) its glycosidic derivatives, apigenin-4'-O-glucoside (A4′G) apigenin-7-O-glucoside (A7G), in reaction mixtures ribose human serum albumin (HSA). The degree ribosylation monitored by ANS AGE-specific fluorescence, UV-vis spectroscopy, confocal microscopy, TNBS, DTNB, DNPH assays, silico evaluation. significant decrease esterase-like activity ribosylated HSA strongly improved...
This study assesses the antifungal efficacy of celery flavonoid-rich extract (CFRE) against cucumber powdery mildew, caused by Podosphaera fusca, in a controlled greenhouse setting. The application CFRE at concentration 4 mg mL− 1 resulted remarkable 97% reduction disease severity. High-performance liquid chromatographic (HPLC) analysis identified apigenin as predominant flavonoid CFRE. Furthermore, treatment induced robust defense response leaves, marked elevated levels flavonoids,...
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, which characterized clinically by serious impairment in memory and cognition. Current medications only slow down the dementia progression present treatment one-drug one-target paradigm for anti-AD appears to be unsuccessful. Therefore, alternative therapeutic strategies are urgently needed. With respect multifunctional multitargeted characteristics of Rosa damascena via its effective flavonoids, we investigated...