A5054986463- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Occupational and environmental lung diseases
- T-cell and B-cell Immunology
- Molecular Junctions and Nanostructures
- Porphyrin and Phthalocyanine Chemistry
- Organometallic Complex Synthesis and Catalysis
- Magnetism in coordination complexes
- Immune Cell Function and Interaction
- Metal complexes synthesis and properties
- Luminescence and Fluorescent Materials
- Medical Imaging and Pathology Studies
- Cancer Research and Treatments
- Crystallography and molecular interactions
- Electrochemical Analysis and Applications
- Monoclonal and Polyclonal Antibodies Research
- Inorganic Chemistry and Materials
- Electrocatalysts for Energy Conversion
- Systemic Lupus Erythematosus Research
- Molecular Sensors and Ion Detection
- Barrier Structure and Function Studies
- Nanocluster Synthesis and Applications
- Polyoxometalates: Synthesis and Applications
- Conducting polymers and applications
- Mycobacterium research and diagnosis
Juntendo University
2013-2025
University of Hyogo
2011-2025
Kawasaki Medical School
2010-2024
Onomichi General Hospital
2024
Tochigi Prefectural Fisheries Experimental Station
2012-2023
Hyogo University
2018
Tokai University
2017
Yamaguchi University
2005-2016
Kyushu University
2007-2016
Screen
2016
The objectives of this study were to establish pure blood-nerve barrier (BNB) and blood-brain (BBB)-derived pericyte cell lines human origin investigate their unique properties as barrier-forming cells. Brain peripheral nerve established via transfection with retrovirus vectors incorporating temperature-sensitive SV40 T antigen (tsA58) telomerase. These expressed several markers such α-smooth muscle actin, NG2, platelet-derived growth factor receptor β, whereas they did not express...
We observed here that the expression of B lymphocyte chemokine (BLC/CXCL13) was markedly enhanced in thymus and kidney aged (NZB × NZW)F1 (BWF1) mice developing lupus nephritis, but not similarly NZB NZW mice. BLC-positive cells were present cellular infiltrates target organs with a reticular pattern staining. CD11b+CD11c+ dendritic increased spleen BWF1 identified as major cell source for BLC. CD4+ T well dramatically mice, whereas no increase B1/B2 ratio significantly higher than those...
Abstract Blockade of the interactions between CD28/CTLA‐4 and their ligands, CD80 (B7, B7.1)/CD86 (B70, B7.2), seems an attractive means to induce antigenspecific peripheral tolerance in organ transplantation autoimmune disease. Recently, diversities CD86 expression, regulation, function have been reported certain cell populations murine experimental disease models. To investigate possible differential role development lupus, we treated lupus‐prone NZB/WF1 mice with specific monoclonal...
Abstract The breakdown of the blood–brain barrier (BBB) has been considered to be a key step in disease process number neurological disorders such as cerebral ischemia and Alzheimer's disease. Many vitro BBB models derived from animal tissues have established elucidate mechanism insufficiency. However, only few human immortalized reported. In present study, temperature‐sensitive SV40‐T antigen was introduced immortalize cells using retrovirus obtain better model which sustains physiological...
Abstract The objective of this study was to establish pure blood–nerve barrier (BNB)‐derived peripheral nerve pericyte cell lines and investigate their unique properties as barrier‐forming cells. We isolated nerve, brain, lung pericytes from transgenic rats harboring the temperature‐sensitive simian virus 40 large T‐antigen gene. These expressed several markers such α‐smooth muscle actin, NG2, osteopontin, desmin, whereas they did not express endothelial vWF PECAM. In addition, these tight...
Background Mesothelioma is a highly malignant tumor that primarily caused by occupational or environmental exposure to asbestos fibers. Despite worldwide restrictions on usage, further cases are expected as diagnosis typically 20–40 years after exposure. Once diagnosed there very poor prognosis with median survival rate of 9 months. Considering this the development early pre clinical diagnostic markers may help improve outcomes. Methodology Microarray expression arrays mesothelium and other...
Abstract Programmed death‐1 (PD‐1) and its ligands, B7‐H1/PD‐L1 B7‐DC/PD‐L2, are new CD28‐B7 family members that may be involved in the regulation of immune responses. We examined roles these molecules mouse hapten‐induced contact hypersensitivity (CH). Administration anti‐PD‐1 mAb at sensitization significantly enhanced prolonged ear swelling. Treatment with anti‐B7‐H1 mAb, but not anti‐B7‐DC also CH reactions. The treatment increased T cell number draining lymph nodes (DLN). B7‐H1 was...
Abstract FcγRIIB1 molecules serve as negative feedback regulator for B cell Ag receptor-elicited activation of cells; thus, any impaired function may possibly be related to aberrant activation. We earlier found deletion polymorphism in the Fcgr2b promoter region among mouse strains which systemic autoimmune disease-prone NZB, BXSB, MRL, and diabetes-prone nonobese diabetic, but not NZW, BALB/c, C57BL/6 mice have two identical sites, consisting 13 3 nucleotides. In this study, we established...
Abstract Inducible costimulator (ICOS)-B7 homologous protein (B7h) is a new member of the CD28-B7 family costimulatory molecules that regulates T cell-dependent humoral immune responses. In this study, we examined involvement pathway in development and progression lupus NZB/W F1 mice. Expression ICOS on cells was enhanced with disease progression, whereas B7h expression B down-regulated. Administration anti-B7h mAb before onset renal significantly delayed proteinuria prolonged survival....
Systemic lupus erythematosus (SLE) is a multigenic disease associated with IgG hypergammaglobulinemia, anti-nuclear antibodies and immune complex (IC)-type glomerulonephritis. In both human murine SLE, one susceptibility allele has been mapped to the interval linked Fc receptor II (FcγRII) gene on chromosome 1. spontaneous SLE models of NZB (NZB × NZW) F1 mice, expression FcγRIIB1, which acts as negative regulator for B cells, was abnormally down-regulated in follicular germinal center cells...
<h3>Objective</h3> Pathological breakdown of the blood-brain barrier (BBB) is thought to constitute beginning disease process in neuromyelitis optica (NMO). In current study, we investigated possible molecular mechanisms responsible for BBB using NMO sera. <h3>Methods</h3> We analysed effects sera obtained from anti-aquaporin 4 (AQP4) antibody-positive spectrum disorder (NMOSD) patients, multiple sclerosis (MS) patients and control subjects on production claudin-5, matrix-metalloproteinases...
Emerging evidence supports the hypothesis that multicellular tumor clusters invade and seed metastasis. However, whether tumor-associated stroma induces epithelial–mesenchymal plasticity in cell clusters, to promote invasion metastasis, remains unknown. We demonstrate herein carcinoma-associated fibroblasts (CAFs) frequently present drive formation of composed two distinct cancer populations, one a highly epithelial (E-cadherin hi ZEB1 lo/neg : E ) state another hybrid epithelial/mesenchymal...
Abstract New chiroptical chromophores, dinuclear triple‐stranded helicates, composed of tetradentate ligands with aluminum(III) ions, are described. These synthesized in two steps using inexpensive pyrrole derivatives, hydrazine, and aluminum chloride. molecular architectures (ALPHY) show multi‐color (cyan, yellow, orange) photoluminescence solution the solid‐state, which depends on substituents ligands. The quantum yields helicates were up to 54 %. right‐handed ( P ) left‐handed M so stable...
This study reports an effective peripheral decoration of organic donor-acceptor diads with B(C6 F5 )3 for stabilizing electrogenerated radical ions. By employing a common p-type semiconductor benzothienobenzothiophene (BTBT) as the donor, tetracoordinate boron complexes showed improved solution electrochemiluminescence (ECL) intensity, reaching 156-fold increase compared to that parent diad. The unprecedented Lewis-pairing-induced ECL enhancement is attributed multiple roles : 1)...
A series of side-on peroxide-bridged binuclear copper complexes [Cu2(NnPY2)(O2)]2+ (where n = 3−5), which have been proposed to adopt a butterfly Cu2O2 geometry due the constraints placed on Cu−Cu distance by alkyl chain linker length −(CH2)n−, studied using absorption and resonance Raman spectroscopy theoretical techniques. The four components peroxide copper(II) charge-transfer transitions identified for first time in 3−5) complexes. observed shift O−O stretch 25 cm-1 higher energy changes...
A new series of oxo-centered acetate-bridged triruthenium comlexes having two redox-active N-methyl-4,4'-bipyridinium ions (mbpy(+)) have been prepared, and their reversible multistep multielectron electrochemical properties are reported: [Ru(III)(2)Ru(II)(&mgr;(3)-O)(&mgr;-CH(3)CO(2))(6)(mbpy(+))(2)(CO)](2+) [Ru(III)(3)(&mgr;(3)-O)(&mgr;-CH(3)CO(2))(6)(mbpy(+))(2)(L)](3+) (L = H(2)O, pyrazine (pz), pyridine (py), imidazole (Him), 4-(dimethylamino)pyridine (dmap)). Among these series, the CO...