A5043895289- Voice and Speech Disorders
- Dysphagia Assessment and Management
- Tracheal and airway disorders
- Intracranial Aneurysms: Treatment and Complications
- Head and Neck Surgical Oncology
- Vascular Malformations Diagnosis and Treatment
- Blood disorders and treatments
- Salivary Gland Tumors Diagnosis and Treatment
- Phonetics and Phonology Research
- Head and Neck Anomalies
- Ear and Head Tumors
- Head and Neck Cancer Studies
- Food composition and properties
- Immunodeficiency and Autoimmune Disorders
- Airway Management and Intubation Techniques
- Otolaryngology and Infectious Diseases
- Moyamoya disease diagnosis and treatment
- Neurosurgical Procedures and Complications
- Oral and Maxillofacial Pathology
- Organic Light-Emitting Diodes Research
- Cell Adhesion Molecules Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Digital Communication and Language
- Neutropenia and Cancer Infections
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Nihon University
1991-2025
Kyushu University
2004-2024
Tsukuba Memorial Hospital
2018-2024
Fujita Health University Hospital
2014-2024
Kyushu Okinawa Agricultural Research Center
2021
University of Tsukuba
2002-2021
International University of Health and Welfare
2015-2020
Katsumata Hospital
2020
Nihon University Itabashi Hospital
2020
Triological Society
2020
A series of carbazole-dendronized tris(2,4,6-trichlorophenyl)methyl (TTM) radicals have been synthesized. The photophysical properties dendronized up to the fourth generation were compared systematically understand how structure-property relationships evolve with generation. photoluminescence quantum yield (PLQY) was found increase increasing generation, and (G4TTM) in cyclohexane solution showed a PLQY as high 63 % at wavelength 627 nm (in deep-red region) from doublet state. dendron...
Torrential and long-lasting rainfall often causes long-duration floods in flat lowland areas data-scarce Nyaungdon Area of Myanmar, imposing large threats to local people their livelihoods. As historical hydrological observations surveys on the impact are very limited, flood hazard assessment mapping still lacked this region, making it hard design implement effective protection measures. This study mainly focuses evaluating predicative capability a 2D coupled hydrology-inundation model,...
Abstract FcγRIIB1 molecules serve as negative feedback regulator for B cell Ag receptor-elicited activation of cells; thus, any impaired function may possibly be related to aberrant activation. We earlier found deletion polymorphism in the Fcgr2b promoter region among mouse strains which systemic autoimmune disease-prone NZB, BXSB, MRL, and diabetes-prone nonobese diabetic, but not NZW, BALB/c, C57BL/6 mice have two identical sites, consisting 13 3 nucleotides. In this study, we established...
Intussusception is the most common cause of intestinal obstruction in young children. The pathogenesis intussusception still not well understood. In this study pathogens from stool specimens were investigated children with intussusception.Patients diagnosed primary idiopathic enrolled. Pathogenic bacteria and viruses detected samples by routine culture, cell polymerase chain reaction, reverse transcriptase-polymerase enzyme immunoassay, electron microscopy examinations.A total 71 analyzed...
Stable organic luminescent radicals have attracted much attention, but their stability under light irradiation is not yet satisfactory. New (TTMs) based on terminal benzene ring modified carbazole donors were synthesized and evaluated. Their photostability (half-life continuous laser irradiation) has improved by 1 order of magnitude compared to simple donors. This a new molecular design strategy improve the without reducing other photophysical properties.
Heterozygosity for dominant-negative STAT1 mutations underlies autosomal dominant Mendelian susceptibility to mycobacterial diseases. Mutations conferring diseases have been identified in the regions of gene encoding tail segment, DNA-binding domain and SH2 domain. We describe here a new heterozygous mutation, Y701C, Japanese two-generation multiplex kindred with This mutation affects precisely canonical tyrosine phosphorylation site. The Y701C protein is produced normally, but its...
Objectives/Hypothesis Severe vocal fold lesions such as sulcus, scars, and atrophy induce a communication disorder due to severe hoarseness, but treatment has not been established. Basic fibroblast growth factor (bFGF) therapies by either four‐time repeated local injections or regenerative surgery for scar sulcus have previously reported, favorable outcomes observed. In this study, we modified bFGF therapy using single of injection, which may potentially be used in office procedures. Study...
Bilateral thyroarytenoid myectomy under microlaryngoscopy by the Muta method (TA myectomy) is a useful surgical treatment for adductor spasmodic dysphonia (ADSD), as long-term-effect can be expected.Botulinum toxin (BT) injection universally accepted first choice of ADSD. However, unfortunately it not covered National Health Insurance in Japan and therefore common practice. So, various other therapeutic modalities have been reported. In current study, we conducted bilateral TA on patients...
Organic luminescent radicals are a new class of materials with potential applications not only in light-emitting devices but also the biochemistry field. New tris(2,4,6-trichlorophenyl)methyl (TTM) alkoxy-substituted carbazole donors were synthesized and characterized. PEG-substituted carbazole-TTM was found to be water-soluble. The water-soluble TTM radical aqueous solution showed fluorescence at 777 nm ability shorten longitudinal relaxation time (T1) water. concept is expected used...
Eleven examples of bisbenzylisoquinoline alkaloids (head-to-head; 10, head-to-tail; 1) and one half molecule type (N-methylcoclaurine), were tested by in vitro histamine release inhibition assay. The order the potency inhibitory effect was ranked thus: homoaromoline, aromoline, isotetrandrine, cepharanthine, fangchinoline, obaberine, tetrandrine. following substances, cepharanoline, berbamine, oxyacanthine, cycleanine (head-to-tail structure) had no effect. N-Methylcoclaurine showed an...
Unilateral vocal cord paralysis (UVCP) not only induces severe dysphonia, but aspiration as well. Although laryngeal framework surgery is usually performed to treat this condition, the procedure tolerated by some patients. In previous study, basic fibroblast growth factor (bFGF) injections for scarring and sulcus have been reported provide favorable outcomes while being minimally invasive. authors retrospectively investigated phonological after bFGF injection in patients with UVCP.This study...
Abstract Much of the pathology systemic lupus erythematosus (SLE) is caused by deposition immune complexes (ICs) into various tissues, including renal glomeruli. Because clearance ICs depends largely on early complement component C1q, homozygous C1q deficiency a strong genetic risk factor in SLE, although it rare SLE patients overall. In this work we addressed issue whether polymorphisms affecting levels may predispose to using (NZB × NZW)F1 model. genes are composed three genes, C1qa, C1qc,...
CD4+ 25+ regulatory T cells (Tregs) play a role in controlling the development and progression of autoimmunity. The transcription factors Foxp3 NFATC2 (NFAT1) key roles regulating function Tregs. present study examined involvement Tregs pathophysiology autoimmune neutropenia children. were analysed by flow cytometry, based on expressions CD4, CD25, intracellular Foxp3. FOXP3 mRNA determined quantitative real-time polymerase chain reaction. percentage 25(high) patients with was significantly...
Objectives/Hypothesis In recent years, basic fibroblast growth factor (bFGF) injection has been used in the treatment of aging‐related vocal fold atrophy. This not only improves closure by increasing mass but also its viscoelasticity. However, it reported that fibroblasts targeted bFGF decrease number with age. The purpose this study was to examine effects local on age‐related atrophy as well influence age phonological outcomes. Study Design Retrospective chart review. Methods Fifty‐three...
ABSTRACT In Japanese soft wheat ( Triticum aestivum L.) breeding programs, protein content (PC), and specific surface area (SSA) of flour have been used as important factors for the baking quality sponge cake. We proposed batter pasting viscosity (BPV) a parameter to predict BPV was measured using Rapid Visco‐Analyser (RVA) with modified heating profile. Twenty samples from 2006‐07 season 22 2007‐08 season, including cultivars, advanced breeders' lines, Western White (WW) imported United...
αIIbβ3 integrin mutations that result in the complete loss of expression this molecule on platelet surface cause Glanzmann thrombasthenia. This is usually autosomal recessive, while other are known to dominantly inherited macrothrombocytopenia (although such cases rare). Here, we report a 4-generation pedigree including 10 individuals affected by thrombocytopenia with anisocytosis. Six individuals, whose detailed clinical and laboratory data were available, carried non-synonymous ITGB3 gene...