A5086694128- Blood disorders and treatments
- Immune Response and Inflammation
- Immunodeficiency and Autoimmune Disorders
- SARS-CoV-2 and COVID-19 Research
- Probiotics and Fermented Foods
- Erythrocyte Function and Pathophysiology
- Immunotherapy and Immune Responses
- Tuberculosis Research and Epidemiology
- T-cell and B-cell Immunology
- Dental Implant Techniques and Outcomes
- Immune Cell Function and Interaction
- Gut microbiota and health
- Pneumonia and Respiratory Infections
- Lipid Membrane Structure and Behavior
- Hematopoietic Stem Cell Transplantation
- COVID-19 Clinical Research Studies
- Mycobacterium research and diagnosis
- Antimicrobial Peptides and Activities
- Neutropenia and Cancer Infections
- Viral gastroenteritis research and epidemiology
- Dental Trauma and Treatments
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- Asthma and respiratory diseases
- Dental materials and restorations
Shinshu University
2012-2024
Japanese Urological Association
2019-2024
New Tokyo Hospital
2020-2024
Civil Engineering Research Institute for Cold Region
2024
Chuo University
2024
Ōtani University
2024
Public Works
2024
Hokkaido University
2024
Iwate Medical University
1998-2023
Doshisha University
2014-2023
Antibody titers against SARS-CoV-2 slowly wane over time. Here, we examined how time affects antibody potency. To assess the impact of maturation on durable neutralizing activity original and emerging variants concern (VOCs), analyzed receptor binding domain (RBD)-specific IgG antibodies in convalescent plasma taken 1-10 months after infection. Longitudinal evaluation total RBD revealed declining but improved neutralization potency per to SARS-CoV-2, indicative response maturation....
The bacterium Flavonifractor plautii (FP), which is found in human feces, has been reported to participate catechin metabolism the gut, but its effects on immune function are unclear. We assessed effect of oral administration FP response ovalbumin (OVA) -sensitized mice. demonstrated that treatment suppressed accumulation interleukin (IL) -4-encoding mRNA splenocytes from OVA-sensitized Moreover, down-regulated OVA-specific immunoglobulin E production serum. In animals + OVA group,...
We generated mouse lacking exon 2 of polymeric Ig receptor (pIgR) gene by a gene-targeting strategy (pIgR-deficient mouse; pIgR-/- mouse) to define the physiological role pIgR in transcytosis Igs. mice were born at expected ratio from cross between pIgR+/- mice, indicating that disruption is not lethal. and secretory component proteins detected Western blot analysis. Moreover, immunohistochemical analysis showed protein expressed jejunal colonic epithelial cells whereas IgA+ are present...
Mucosal delivery of therapeutic proteins using genetically modified strains lactic acid bacteria (gmLAB) is being investigated as a new strategy. We developed strain gmLAB, Lactococcus lactis NZ9000 (NZ-HO), which secretes the anti-inflammatory molecule recombinant mouse heme oxygenase-1 (rmHO-1). The effects short-term continuous oral dosing with NZ-HO were evaluated in mice dextran sulfate sodium (DSS)-induced acute colitis model inflammatory bowel diseases (IBD). identified secretion...
Flavonifractor plautii (FP) has been reported to participate in the metabolism of catechins human gut. However, there is limited information on immune regulatory effects this bacterium. We confirmed that administration green tea increases abundance FP gut microbiota and investigated effect a mouse colitis model. Mice were orally administered for 10 consecutive days; colonic inflammation was evaluated daily basis stool consistency, gross rectal bleeding, body weight. In dextran sodium sulfate...
The effects of insulin and insulin‐like growth factor I (IGF‐I) on the proliferation erythroid progenitor cells in bone marrow were studied serum‐deprived culture. Primitive human purified by cell sorting basis expression CD34 Kit receptor. Insulin IGF‐I with erythropoietin (EPO) dose dependently supported formation colonies + /Kit marrow. direct effect stimulation primitive was confirmed single‐cell studies liquid suspension addition and/or to stem (SCF) resulted an additive increase number...
Rationale: Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, has antioxidative, antiapoptotic, and antiinflammatory activities. We examined whether HO-1 might be involved silicosis.Objectives: To investigate can reduce silicosis mice humans.Methods measurements: Silicosis was studied using murine model, 46 male patients. Serum 8-hydroxydeoxyguanosine (a marker of oxidative stress) were measured by enzyme-linked immunosorbent assay. Levels immunohistochemistry...
Recent results [Morata, G. & Kerridge, S. (1981) Nature (London) 290, 778-781] have shown that early Ultrabithorax- clones transform the posterior compartments of adult meso- and metathoracic legs to prothorax. These transformations not been seen in Ultrabithorax homozygous larvae, which are reported show only metathorax first abdominal segment mesothorax [Lewis, E. B. (1978) 276, 565-570]. However, as ventral surface larva does exhibit sufficient markers distinguish regions these...
Polo-like kinase 1 (PLK1) is a serine/threonine protein involved in key processes during mitosis. Human PLK1 has been shown to be overexpressed various human cancers, and elevated levels of have associated with poor prognosis, making it an attractive target for anticancer therapy. TAK-960 [4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl) benzamide] novel, investigational, orally...
Wound healing is mediated through complex interactions between circulating immune cells and local epithelial endothelial cells. Elements of the innate system are triggered when Toll-like receptors (TLR) stimulated by their cognate ligands, previous studies suggest that such can accelerate wound healing. This work examines effect treating excisional skin biopsies with immunostimulatory CpG oligodeoxynucleotides (ODN) trigger via TLR9. Results indicate (but not control) ODN closure reduce...
Adaptive immunity is a fundamental component in controlling COVID-19. In this process, follicular helper T (Tfh) cells are subset of CD4+ that mediate the production protective antibodies; however, SARS-CoV-2 epitopes activating Tfh not well characterized. Here, we identified and crystallized TCRs public circulating (cTfh) clonotypes expanded patients who have recovered from mild symptoms. These recognized spike (S) conserved across emerging variants. The epitope most prevalent cTfh...
Abstract The immunogenicity of mRNA vaccines has not been well studied when compared to different vaccine modalities in the context additional boosters. Here we show that longitudinal analysis reveals more sustained SARS-CoV-2 spike receptor-binding domain (RBD)-binding IgG titers with breadth antigenically distinct variants by S-268019-b protein booster BNT162b2 homologous booster. durability and RBD-angiotensin-converting enzyme 2 (ACE2) binding inhibitory antibodies are pronounced group...