A5101479547- T-cell and B-cell Immunology
- SARS-CoV-2 and COVID-19 Research
- Air Quality and Health Impacts
- Adrenal and Paraganglionic Tumors
- Medical and Biological Sciences
- COVID-19 Clinical Research Studies
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Systemic Lupus Erythematosus Research
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Immune Cell Function and Interaction
- Vehicle emissions and performance
- Nuclear Receptors and Signaling
- Atmospheric chemistry and aerosols
- Historical and Scientific Studies
- Adrenal Hormones and Disorders
- vaccines and immunoinformatics approaches
Osaka University
2021-2024
Osaka International University
2024
Adaptive immunity is a fundamental component in controlling COVID-19. In this process, follicular helper T (Tfh) cells are subset of CD4+ that mediate the production protective antibodies; however, SARS-CoV-2 epitopes activating Tfh not well characterized. Here, we identified and crystallized TCRs public circulating (cTfh) clonotypes expanded patients who have recovered from mild symptoms. These recognized spike (S) conserved across emerging variants. The epitope most prevalent cTfh...
Nuclear receptors are involved in a wide variety of functions, including aldosteronogenesis. receptor families NR4A [nerve growth factor-induced clone B (NGFIB), Nur-related factor 1 (NURR1) and neuron-derived orphan (NOR1)] NR2F [chicken ovalbumin upstream promoter-transcription (COUP-TFI), COUP-TFII NR2F6) activate, whereas NR5A1 [steroidogenic (SF1)] represses CYP11B2 (aldosterone synthase) gene transcription. The present study was undertaken to elucidate the mechanism differential...
Objective: The mineralocorticoid Receptor (MR) is expressed not only in the kidneys but also adipose tissue, and primary aldosteronism (PA) associated with metabolic syndrome. This study assessed effects of aldosterone blockade on factors patients PA. Method: Sixty-five PA were treated one two MR antagonists; eplerenone (50-100 mg, daily, n=38) or spironolactone (25-50 n=27) for 14 months. Visceral (VAT) subcutaneous tissue (SAT) quantified using CT “Fat Scan” imaging analysis software. Body...
Summary T cells play pivotal roles in protective immunity against SARS-CoV-2 infection. Follicular helper (Tfh) mediate the production of antigen-specific antibodies; however, cell receptor (TCR) clonotypes used by SARS-CoV-2-specific Tfh have not been well characterized. Here, we first identified and crystallized public TCR that are shared expanded unhospitalized COVID-19-recovered patients. These preferentially recognized spike (S) protein epitopes which conserved among emerging variants....