A5032665333- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Estrogen and related hormone effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Renin-Angiotensin System Studies
- Apelin-related biomedical research
- Endometriosis Research and Treatment
- Pituitary Gland Disorders and Treatments
- Eicosanoids and Hypertension Pharmacology
- Epigenetics and DNA Methylation
- Diet and metabolism studies
- Birth, Development, and Health
- Gut microbiota and health
- Electrolyte and hormonal disorders
- Nuclear Receptors and Signaling
- Ion Transport and Channel Regulation
- Nutritional Studies and Diet
- Posttraumatic Stress Disorder Research
- Folate and B Vitamins Research
- Sexual Differentiation and Disorders
- Congenital heart defects research
- Cancer-related gene regulation
- Genomics and Chromatin Dynamics
- Resilience and Mental Health
Kanazawa University
2015-2024
Tohoku University Hospital
2013
Fukui Red Cross Hospital
2013
Kanazawa University Hospital
2012
Northwestern University
2005-2011
University of Fukui
2000
Symptomatic uterine leiomyoma is associated with irregular bleeding, anemia, and recurrent pregnancy loss. African-American women develop leiomyomas at an earlier age higher frequency compared Caucasian-American or other races; however, the underlying mechanism for this discrepancy unknown.Our objective was to determine whether gene targets of emerging therapeutics such as aromatase inhibitors antiprogestins, which reduce tumor size symptoms, are differentially expressed in tissues (n = 31),...
Abstract —Aldosterone is synthesized in extra-adrenal tissues, both blood vessels and brain. We undertook the present study to determine whether rat heart produces aldosterone investigate effects of adrenalectomy, ACE inhibition, angiotensin II on synthesis heart. To clarify pathophysiological role cardiac hypertensive heart, we compared hearts stroke-prone spontaneously rats (SHRSP) with that Wistar-Kyoto rats. The antagonist spironolactone myocardial hypertrophy adrenalectomized SHRSP were...
Adrenal vein sampling (AVS) is essential for identifying a surgically curable form of primary aldosteronism (PA), but accurate placement the catheter technically challenging. Intraprocedural cortisol measurement can confirm catheter's position, thereby increasing AVS success rate. We developed quick assay (QCA) that uses immunochromatography and gold nanoparticles be performed either semiquantitatively or quantitatively. The was evaluated in two studies. In single-center study, PA patients...
ABSTRACT High sodium intake causes cardiac hypertrophy independently of increases in blood pressure. Aldosterone is synthesized extra- adrenal tissues such as vessels, brain, and heart. Effects 8 weeks high on aldosterone synthesis, well structure, mass, production, levels mRNA coding for synthase (CYP11B2) the angiotensin II AT 1 receptor, were studied normotensive Wistar-Kyoto (WKY) rats. Isolated rat hearts perfused 2 hr, perfusate was analyzed by high-performance liquid chromatography...
DNA methylation patterns are maintained in adult somatic cells. Recent findings, however, suggest that all not preserved. We demonstrate stimulatory signals can change the status at a CCAAT/enhancer binding protein (CEBP) site and transcription start activate expression of angiotensinogen gene ( AGT ). A CEBP human promoter was hypomethylated tissues with high , but those low expression. The transcriptional activity sequences cloned into reporter plasmid depended on methylation. In cultured...
It remains unclear how mineralocorticoids induce cardiac hypertrophy and fibrosis. Recently, activation of the calcium-dependent phosphatase, calcineurin, has been shown to hypertrophy. In present study, we examine role calcineurin in mineralocorticoid-induced fibrosis.Uninephrectomized Wistar-Kyoto rats were placed on a 1.0% NaCl diet treated with aldosterone (0.75 microg x h(-1)) for 6 weeks or without inhibitors, FK506 (0.5 mg kg(-1) d(-1)) cyclosporine A (10 d(-1)). The effect...
Objectives Aldosterone is synthesized in extra-adrenal tissues such as the vasculature, heart and brain. The mechanisms underlying effect of high salt intake on development acceleration vascular injury cardiac hypertrophy stroke-prone spontaneously hypertensive rats (SHRSP) are still not clear. goal this study was to determine whether increases cardiovascular aldosterone synthesis SHRSP. Methods Four-week-old SHRSP were given tap water or 0.9% NaCl solution for hydration 4 weeks addition a...
Production of appropriate quantities estrogen in various tissues is essential for human physiology. A single gene ( CYP19 ), regulated via tissue-specific promoters, encodes the enzyme aromatase, which catalyzes key step biosynthesis. Aromatase excess syndrome inherited as autosomal dominant and characterized by high systemic levels, short stature, prepubertal gynecomastia testicular failure males, premature breast development uterine pathology females. The underlying genetic mechanism...
Obstructive sleep apnea syndrome (OSAS) is often associated with metabolic disorders such as obesity and type 2 diabetes may contribute to cardiovascular events. A novel class of antidiabetic drugs, the sodium glucose cotransporter inhibitors (SGLT2i) reduce body weight (BW), although there limited data on their impact OSAS. We therefore evaluated effect SGLT2i OSAS in patients diabetes. The presented study was a retrospective design 18 (4 males, age range 39-81 yr) administrated SGLT2i....
DNA methylation is believed to be maintained in adult somatic cells. Recent findings, however, suggest that all patterns are not stable. We demonstrate stimulatory signals can change the status around transcription factor binding sites and a start site activate expression of aldosterone synthase gene (CYP11B2).DNA CYP11B2 was analyzed aldosterone-producing adenomas, nonfunctioning adrenal glands compared with levels. CpG dinucleotides promoter were found hypormethylated tissues high...
The (pro)renin receptor exists in the kidney, blood vessels and heart. (Pro)renin binds to induces tissue injuries directly, completely independent of angiotensin II (Ang II). renal renin-angiotensin-aldosterone system is activated salt-sensitive hypertensive rats with in-vitro studies showing aldosterone increases angiotensin-converting enzyme (ACE) activity, renin production type 1 (AT1R) activity. However, effect blockade mineralocorticoid on receptor, angiotensinogen, ACE AT1R Dahl...
Aromatase is essential for estrogen production and the target of aromatase inhibitors, most effective endocrine treatment postmenopausal breast cancer. Peripheral tissues in women, including breast, express via alternative promoters. Female mice lack promoters that drive expression peripheral tissues; thus, we generated a transgenic humanized (Arom(hum)) mouse line containing single copy human gene to study link between mammary adipose tissue pathology. Arom(hum) expressed aromatase, driven...
Abstract Adrenocortical hormone excess, due to primary aldosteronism (PA) or hypercortisolemia, causes hypertension and cardiovascular complications. In PA, hypomethylation of aldosterone synthase ( CYP11B2 ) is associated with overproduction. However, in the role DNA methylation 11β-hydroxylase CYP11B1 ), which catalyzes cortisol biosynthesis highly homologous , unclear. The aims our study were determine whether expression was regulated through hypercortisolemia cortisol-producing adenoma...
Medical treatment with a mineralocorticoid receptor (MR) antagonist, which has produced spontaneous remission of bilateral primary aldosteronism (PA), may also produce unilateral PA, for laparoscopic adrenalectomy is recommended. However, few reports exist regarding after MR antagonist therapy in PA.The aim this paper to report case PA and reduction cardiac hypertrophy long-term spironolactone (SP) therapy.A 41-yr-old Japanese male was treated hypertension hypokalemia 5 yr. Primary diagnosed...
Indonesia is ranked as the 4th highest contributor to tuberculosis (TB) in world. Semarang District Central Java displays extremely low case detection rate (CDR), possibly contributing local prevalence of TB.A case-control study was performed explore factors that cause such CDR. We recruited 129 TB cases and 83 controls visited same centers were not diagnosed with TB.The had 7.5 ± 2.3 symptoms/person on average, indicating delay diagnosis because only displayed 1.0 1.7. The multiple logistic...