A5055679381- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Endometriosis Research and Treatment
- Cancer Risks and Factors
- Reproductive System and Pregnancy
- Maternal and fetal healthcare
- Blood Pressure and Hypertension Studies
- Infant Nutrition and Health
- Endometrial and Cervical Cancer Treatments
- Congenital Diaphragmatic Hernia Studies
- Preterm Birth and Chorioamnionitis
- Maternal and Perinatal Health Interventions
- Gestational Diabetes Research and Management
- Genetic and Kidney Cyst Diseases
- Assisted Reproductive Technology and Twin Pregnancy
- Hormonal Regulation and Hypertension
- Microtubule and mitosis dynamics
- Prenatal Screening and Diagnostics
- Cardiovascular Issues in Pregnancy
- Pregnancy and Medication Impact
- Kruppel-like factors research
- Genetic Syndromes and Imprinting
- COVID-19 Impact on Reproduction
University of Colorado Denver
2015-2024
University of Colorado Boulder
2022-2024
University of South Alabama
2022-2024
Duke University
2022-2024
University of Alabama at Birmingham
2024
University of North Carolina at Chapel Hill
2022-2024
University of Colorado Anschutz Medical Campus
2016-2024
University of Pennsylvania
2022-2024
Indiana University – Purdue University Indianapolis
2022-2024
Drexel University
2022-2024
The benefits and safety of the treatment mild chronic hypertension (blood pressure, <160/100 mm Hg) during pregnancy are uncertain. Data needed on whether a strategy targeting blood pressure less than 140/90 Hg reduces incidence adverse outcomes without compromising fetal growth.In this open-label, multicenter, randomized trial, we assigned pregnant women with singleton fetuses at gestational age 23 weeks to receive antihypertensive medications recommended for use in (active-treatment group)...
During human pregnancy, the fetal circulation is separated from maternal blood in placenta by two cell layers - capillary endothelium and placental trophoblast. This barrier plays an essential role development health tightly regulating exchange of endogenous exogenous materials between mother fetus. Here we present a microengineered device that provides novel platform to mimic structural functional complexity this specialized tissue vitro. Our model created multilayered microfluidic system...
Pregnant women worldwide have been affected by COVID-19. As the virus is commonly spread to various organs via bloodstream and because human placental trophoblasts are directly bathed in maternal blood, feto-placental infection SARS-CoV-2 seems likely.
In endometriosis, stromal and epithelial cells from the endometrium form extrauterine lesions persist in response to estrogen (E2) prostaglandin E2 (PGE2). Stromal produce excessive quantities of PGE2 a feed-forward manner. However, it is unknown how stimulates cell proliferation survival for establishment persistence disease. Previous studies suggest that receptor-β (ERβ) strikingly overexpressed endometriotic cells. Thus, we integrated genome-wide ERβ binding data previously published...
To investigate the optimal gestational age to deliver pregnant people with chronic hypertension improve perinatal outcomes.
Fetal growth restriction with abnormal umbilical artery Doppler velocimetry (FGRadv), reflective of elevated fetoplacental vascular resistance, is associated increased risks fetal morbidity and mortality even in comparison to those growth-restricted fetuses normal placental blood flow. One major cause this abnormally resistance the aberrantly formed, thin, elongated villous vessels that are seen FGRadv placentas.The purpose study was determine role endothelial cells (ECs) angiogenesis...
Preeclampsia and fetal growth restriction increase cardiopulmonary disease risk for affected offspring occur more frequently at high-altitude (≥2500 m). Retrospective studies indicate that birth to a preeclampsia woman high altitude increases the of pulmonary hypertension (PH) in later life. This prospective study asked whether with or without exaggerated hypoxia impaired angiogenesis lung, leading neonatal circulation abnormalities infantile PH.
Context:Fetal growth restriction (FGR) due to placental dysfunction impacts short- and long-term neonatal outcomes. Abnormal umbilical artery Doppler velocimetry indicating elevated fetoplacental vascular resistance has been associated with fetal morbidity mortality. Estrogen receptors are regulators of vasomotor tone, endothelium expresses estrogen receptor-β (ESR2) as its sole receptor.