A5016476049- Neonatal Respiratory Health Research
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Birth, Development, and Health
- Neonatal and Maternal Infections
- Preterm Birth and Chorioamnionitis
- Infant Development and Preterm Care
- Neonatal and fetal brain pathology
- Neuroscience of respiration and sleep
- Gestational Diabetes Research and Management
- Maternal and fetal healthcare
- Parathyroid Disorders and Treatments
- Infant Nutrition and Health
- Renal and related cancers
- Fibroblast Growth Factor Research
- Genetic Syndromes and Imprinting
- Congenital Heart Disease Studies
- Bacterial Identification and Susceptibility Testing
- Pulmonary Hypertension Research and Treatments
- Pregnancy-related medical research
- Epigenetics and DNA Methylation
- Maternal Mental Health During Pregnancy and Postpartum
- Childhood Cancer Survivors' Quality of Life
- Ectopic Pregnancy Diagnosis and Management
- Chronic Obstructive Pulmonary Disease (COPD) Research
Lurie Children's Hospital
2015-2025
Northwestern University
2016-2025
Rady Children's Hospital-San Diego
2022-2025
University of California, San Diego
2022-2025
Northwestern Medicine
2018
RELX Group (Netherlands)
2017
Cambridge University Press
2011
New York University Press
2011
Chitose Institute of Science and Technology
2011
University of Hertfordshire
2011
Chronic lung disease and severe intraventricular hemorrhage or periventricular leukomalacia in premature infants are associated with abnormal neurodevelopmental outcomes. In a previous randomized, controlled, single-center trial of the respiratory distress syndrome, inhaled nitric oxide decreased risk death chronic as well leukomalacia. We hypothesized that treated would also have improved outcomes.We conducted prospective, longitudinal follow-up study who had received placebo to investigate...
Inflammation has been associated with preterm delivery and adverse neonatal outcomes such as cerebral palsy chronic lung disease. However, no study to date simultaneously examined a wide range of inflammatory mediators their relationship gestational age. We sought describe the distribution immune biomarkers in cord blood across age investigate association between biomarker level patterns birth.As part large-scale molecular epidemiological birth conducted at Boston Medical Center, this...
Maternal obesity is associated with a variety of common diseases in the offspring. One possible underlying mechanism could be maternal induced alterations DNA methylation. However, this hypothesis yet to tested. We performed epigenomic mapping cord blood among 308 Black mother‐infant pairs delivered at term Boston Medical Center using Illumina HumanMethylation27 BeadChip. Linear regression and pathway analyses were conducted evaluate associations between methylation levels prepregnancy BMI...
OBJECTIVE: We sought to determine whether placental markers of intrauterine inflammation were associated with poor weight gain among premature infants in the neonatal period. METHODS: reviewed 697 preterm births prospectively enrolled as part an ongoing molecular epidemiological study. Placental and serial analyzed for who hospitalized ≥21 days (N = 256). Placentas examined maternal inflammatory response (MIR), defined subchorionitis, chorioamnionitis, deciduitis, or free membranitis, fetal...
Background Early onset sepsis (EOS) is a major cause of morbidity and mortality in preterm infants, yet diagnosis remains inadequate resulting missed cases or prolonged empiric antibiotics with adverse consequences. Evaluation acute phase reactant (APR) biomarkers umbilical cord blood at birth may improve EOS detection infants intrauterine infection. Methods In this nested case-control study, (29.7 weeks gestation, IQR: 27.7–32.2) were identified from longitudinal cohort archived placental...
Pulmonary hypertension (PH) is a common consequence of bronchopulmonary dysplasia (BPD) and remains primary contributor to increased morbidity mortality among preterm infants. Unfortunately, at the present time, there are no reliable early predictive markers for BPD-associated PH. Considering its health consequences, understanding in utero perturbations that lead development BPD PH identifying utmost importance. As part discovery phase, we applied multiplatform metabolomics approach...
Objective. In current, neonatal practice, clinical signs of intrauterine infection (IUI) are often non-specific. From a large panel immune biomarkers, we seek to identify cord blood markers that most strongly associated with the fetal inflammatory response (FIR), specific placental lesion serious complications.
The development of pulmonary hypertension (PH) is a serious complication bronchopulmonary dysplasia (BPD) among infants born at extremely low gestational ages. Bronchopulmonary dysplasia-associated PH characterized by persistent vasoconstriction, progressive right heart dysfunction, and an increased risk death. We have shown previously that certain placental vascular lesions are associated with BPD-associated PH. Further evaluation the villous morphometry these placentas warranted. Using...
Fetal growth restriction with abnormal umbilical artery Doppler velocimetry (FGRadv), reflective of elevated fetoplacental vascular resistance, is associated increased risks fetal morbidity and mortality even in comparison to those growth-restricted fetuses normal placental blood flow. One major cause this abnormally resistance the aberrantly formed, thin, elongated villous vessels that are seen FGRadv placentas.The purpose study was determine role endothelial cells (ECs) angiogenesis...
Abstract Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis fibrosis. Here we test the hypothesis decreased cord levels in preterm predict increased BPD–PH risk early supplementation prevents BPD-like phenotype PH rodents exposed to neonatal hyperoxia. In experiment 1, were measured blood of who enrolled a longitudinal cohort...
Neonatal health is dependent on early risk stratification, diagnosis, and timely management of potentially devastating conditions, particularly in the setting prematurity. Many these conditions are poorly predicted real-time by clinical data current diagnostics. Umbilical cord blood may represent a novel source molecular signatures that provides window into state fetus at birth. In this study, we comprehensively characterized proteome infants born between 25 to 42 weeks using untargeted mass...