A5050870557- Neonatal Respiratory Health Research
- Fibroblast Growth Factor Research
- Congenital Diaphragmatic Hernia Studies
- Urological Disorders and Treatments
- Bladder and Urothelial Cancer Treatments
- Cardiac Arrest and Resuscitation
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Renal Diseases and Glomerulopathies
- Family and Patient Care in Intensive Care Units
- Extracellular vesicles in disease
- Nitric Oxide and Endothelin Effects
- Diversity and Career in Medicine
- Pelvic floor disorders treatments
- Chemotherapy-induced organ toxicity mitigation
- Simulation-Based Education in Healthcare
- Child and Adolescent Health
- MicroRNA in disease regulation
- Ureteral procedures and complications
- Gynecological conditions and treatments
- Medical Imaging and Pathology Studies
- Neonatal and fetal brain pathology
- Disaster Response and Management
- Cancer, Hypoxia, and Metabolism
- Palliative Care and End-of-Life Issues
University of Miami Hospital
2025
Children’s Institute
2022-2024
University of Miami
2020-2024
Jackson Memorial Hospital
2019-2023
Memorial Medical Center
2023
University of Pittsburgh
2022
Children's Hospital of Pittsburgh
2022
Abstract Preterm infants with bronchopulmonary dysplasia (BPD) and pulmonary hypertension (PH) have accelerated lung aging poor long-term outcomes. Klotho is an antiaging protein that modulates oxidative stress, angiogenesis fibrosis. Here we test the hypothesis decreased cord levels in preterm predict increased BPD–PH risk early supplementation prevents BPD-like phenotype PH rodents exposed to neonatal hyperoxia. In experiment 1, were measured blood of who enrolled a longitudinal cohort...
Bronchopulmonary dysplasia (BPD) is a life-threatening condition in preterm infants with few effective therapies. Mesenchymal stem or stromal cells (MSCs) are promising therapeutic strategy for BPD. The ideal MSC source BPD prevention however unknown. objective of this study was to compare the regenerative effects obtained from bone marrow (BM) and umbilical cord tissue (UCT) an experimental model. In vitro, UCT-MSC demonstrated greater proliferation expression anti-inflammatory cytokines as...
Megalourethra is a rare congenital condition marked by dilation and elongation of the penile urethra, resulting from hypoplasia either corpus spongiosum or cavernosa. We describe novel case male infant prenatally diagnosed with megalourethra who subsequently developed rapid-onset anhydramnios advanced renal failure. Unlike previously described cases, this unique due to patient's abrupt progression at 34 weeks 5 days, despite having normal amniotic fluid levels prior that. With late-onset...
OSBPL7 and ER stress comprise a central mechanism in glomerular injury. This study highlights crucial link between deficiency CKD. causes stress, leading to podocyte apoptosis. There is selective effect on lipid homeostasis that affects homeostasis, altering cellular triglyceride but not cholesterol content. The interaction of apoptosis supports reduced autophagy, the main driver OSBPL7-deficient podocytes.
Although full-length fibroblast growth factor 7 (FGF7) blocks cyclophosphamide-induced urothelial apoptosis in mice, limitations include high production costs because of its large size. We previously identified a small peptide derived from FGF2 that mitigated acute radiation syndrome as well FGF2. Based on the sequence peptide, we synthesized corresponding 19 amino acid FGF7 (FGF7p). Our objectives were to determine if systemic FGF7p triggered downstream targets and protected against...
Preterm infants are increasingly susceptible to renal dysfunction, which has been correlated with podocyte derangement. Hyperoxia demonstrated damage structure and function. The molecular pathways contributing this phenomenon, particularly those involving Oxysterol-Binding Protein Like 7 (OSBPL7) Hypoxia-Inducible Factor 1alpha (HIF-1α), remain elusive. This study aims unravel these underpinnings
Oxysterol-binding proteins (OSBPs) are known for their multifaceted roles, including the transfer of cholesterol between endoplasmic reticulum and Golgi apparatus, as well regulating efflux. Recent evidence suggests that deficiency one specific OSBP, OSBPL7, can attenuate autophagic processes in various cell types, thereby potentially influencing lipid trafficking functionality podocytes—key cells involved renal filtration. Given these preliminary observations, current study aims to...
Mice with inducible urothelial deletion of fibroblast growth factor receptor 2 (ShhCreERT2;Fgfr2
PURPOSE Debriefing is a facilitated discussion of actions and thought processes used to encourage reflection assimilation learning after stressful events. resuscitations can be facilitate learning, improve future performance, reduce the stress response. Post-resuscitation debriefing (PRD) has potential attenuate factors leading burnout by providing an opportunity for emotional processing, review improvement morale. Pediatric residents comprise population which would benefit extensively from...
Abstract We previously identified a peptide derived from human fibroblast growth factor 7 (FGF7p) that blocks urothelial apoptosis similar to full‐length FGF7, although effects of FGF7p on repair are unknown. Also, while AKT activation downstream correlated with the anti‐apoptotic effects, we have not directly interrogated role in mediating cytoprotection. Our goal was assess and signaling cytoprotective FGF7p. performed hematoxylin eosin (H&E), TUNEL, and/or immunofluorescence (IF)...
Introduction: Bronchopulmonary dysplasia (BPD) or chronic lung injury of newborn is a life-threatening condition in preterm infants with few effective therapies. Mesenchymal stem cells (MSC) are promising therapeutic strategy for BPD. The ideal MSC source BPD prevention however unknown. Umbilical cord tissue (UCT) may potentially have more anti-inflammatory and pro-angiogenic properties. Hypothesis: We hypothesized that the UCT-MSC will superior regenerative effect owing to properties as...