Hui‐Chien Kuo
A5026981314- Cytomegalovirus and herpesvirus research
- Pregnancy and preeclampsia studies
- Herpesvirus Infections and Treatments
- Myasthenia Gravis and Thymoma
- Parvovirus B19 Infection Studies
- Parkinson's Disease and Spinal Disorders
- Thyroid and Parathyroid Surgery
- Birth, Development, and Health
- Cell death mechanisms and regulation
- Blood Pressure and Hypertension Studies
- Adipose Tissue and Metabolism
- Peripheral Neuropathies and Disorders
- Angiogenesis and VEGF in Cancer
- Maternal and fetal healthcare
- Viral gastroenteritis research and epidemiology
- Glioma Diagnosis and Treatment
- Electron Spin Resonance Studies
- Health, Environment, Cognitive Aging
- Peroxisome Proliferator-Activated Receptors
- Air Quality and Health Impacts
- Gout, Hyperuricemia, Uric Acid
- Liver Disease Diagnosis and Treatment
- Urticaria and Related Conditions
- Reproductive Health and Contraception
- Neonatal Respiratory Health Research
University of Alabama at Birmingham
2014-2024
George Washington University
2020
Medical University of South Carolina
2015
Lucile Packard Children's Hospital
2015
University College London
2015
University of Alabama
2010-2015
Johns Hopkins University
2015
Children's National
2015
Children's Hospital of Orange County
2015
Bristol Royal Hospital for Children
2015
Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence its benefit. We conducted multicenter, randomized trial comparing thymectomy plus prednisone with alone.We compared extended transsternal alternate-day alone. Patients 18 to 65 years age who had generalized nonthymomatous gravis disease duration less than 5 were included if they Myasthenia Gravis Foundation America clinical class II IV (on scale from I V, higher classes indicating more...
The treatment of symptomatic congenital cytomegalovirus (CMV) disease with intravenous ganciclovir for 6 weeks has been shown to improve audiologic outcomes at months, but the benefits wane over time.We conducted a randomized, placebo-controlled trial valganciclovir therapy in neonates CMV disease, comparing months therapy. primary end point was change hearing better ear ("best-ear" hearing) from baseline months. Secondary points included follow-up 12 and 24 neurodevelopmental outcomes, each...
Poor neurodevelopmental outcomes and recurrences of cutaneous lesions remain unacceptably frequent among survivors neonatal herpes simplex virus (HSV) disease.We enrolled neonates with HSV disease in two parallel, identical, double-blind, placebo-controlled studies. Neonates central nervous system (CNS) involvement were one study, skin, eye, mouth only the other. After completing a regimen 14 to 21 days parenteral acyclovir, infants randomly assigned immediate acyclovir suppression (300 mg...
G207, a mutant herpes simplex virus (HSV) type 1, is safe when inoculated into recurrent malignant glioma. We conducted phase 1 trial of G207 to demonstrate the safety stereotactic intratumoral administration given 24 hours prior single 5 Gy radiation dose in patients with Nine progressive, glioma despite standard therapy were included. Patients received one stereotactically multiple sites enhancing tumor margin and then treated focally radiation. Treatment was well tolerated, no patient...
Abstract Purpose: To determine the maximum tolerated dose (MTD), toxicity spectrum, clinical activity, and biological effects of tropism-modified, infectivity-enhanced conditionally replicative adenovirus (CRAd), Ad5–Δ24–Arg-Gly-Asp (RGD), in patients with malignant gynecologic diseases. Experimental Design: Cohorts eligible were treated daily for 3 days through an i.p. catheter. Vector doses ranged from 1 × 109 to 1012 viral particles per day. Toxicity was evaluated using CTCv3.0. CA-125...
Pegloticase is used for the treatment of severe gout, but its use limited by immunogenicity. This study was undertaken to evaluate whether mycophenolate mofetil (MMF) prolongs efficacy pegloticase.Participants were randomized 3:1 receive 1,000 mg MMF twice daily or placebo 14 weeks, starting 2 weeks before receiving pegloticase and continuing while intravenous 8 biweekly 12 weeks. Participants then received alone from week 24. The primary end points proportion patients who sustained a serum...
Viral loads (VLs) frequently are followed during treatment of symptomatic congenital cytomegalovirus disease, but their predictive value is unclear.Post hoc analysis 2 antiviral studies was performed. Seventy-three subjects were treated for 6 weeks and 47 months. Whole blood VL determined by real-time polymerase chain reaction before therapy.Higher baseline associated with central nervous system involvement (3.82 log, range 1-5.65 vs 3.32 1-5.36; P = .001), thrombocytopenia (3.68 3.43 .03),...
To determine the maximum tolerated dose of ABT-510, a thrombospondin-1 mimetic drug with antiangiogenic properties, when used concurrently temozolomide and radiotherapy in patients newly diagnosed glioblastoma.Phase 1 dose-escalation clinical trial.Comprehensive Cancer Center, University Alabama at Birmingham. Patients A total 23 diagnosed, histologically verified glioblastoma enrolled between April 2005 January 2007.Four cohorts 3 each received subcutaneous ABT-510 injection doses 20, 50,...
To investigate the optimal gestational age to deliver pregnant people with chronic hypertension improve perinatal outcomes.
TRA-8, a monoclonal antibody to death receptor 5 induces apoptosis in various cancer cells; however, the degree of sensitivity varies from highly sensitive resistant. We have previously shown that resistance TRA-8 can be reversed by using chemotherapeutic agents, but mechanism underlying this sensitization was not fully understood. Here, we examined combination with doxorubicin or bortezomib breast cells. In TRA-8-resistant BT-474 and T47D cells, both chemotherapy agents synergistically...
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<h3>Objective</h3> To examine whether sustained minimal manifestation status (MMS) with complete withdrawal of prednisone is better achieved in thymectomized patients myasthenia gravis (MG). <h3>Methods</h3> This study a post hoc analysis data from randomized trial thymectomy MG (Thymectomy Trial Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy [MGTX]). MGTX was multicenter, randomized, rater-blinded 3-year that followed by voluntary 2-year extension for acetylcholine...
OBJECTIVE: To evaluate the association between maternal blood pressure (BP) below 130/80 mm Hg compared with 130–139/80–89 and pregnancy outcomes. METHODS: We conducted a planned secondary analysis of CHAP (Chronic Hypertension Pregnancy), an open label, multicenter, randomized controlled trial. Participants mean BP 140/90 were grouped as by averaging postrandomization clinic throughout pregnancy. The primary composite outcome was preeclampsia severe features, indicated preterm birth before...
<h3>Importance</h3> Despite a high disease burden, there is no effective treatment for respiratory syncytial virus (RSV) infection. <h3>Objectives</h3> To determine whether administration of azithromycin (AZM) to children with RSV-induced failure safe and define the effect AZM therapy on nasal matrix metalloproteinase 9 (MMP-9) levels. <h3>Design, Setting, Participants</h3> This randomized, double-blind, placebo-controlled phase 2 trial was conducted at single tertiary pediatric intensive...
The etiology of late-onset Alzheimer's disease is unknown. Recent epidemiological studies suggest that exposure to high levels ozone (O3) may be a risk factor for disease. Nonetheless, whether and how O3 contributes AD development remains determined. In this study, we tested the hypothesis synergizes with genetic APOE ε4 aging leading AD, using male apolipoprotein E (apoE)4 apoE3 targeted replacement mice as men have increased via working environments few addressed effects on males....
The matricellular protein osteopontin (OPN), expressed in various cancer types and elevated the blood of patients, is thought to have different functions when derived from host versus cells. To assess effect host-derived OPN on growth cancers epithelial origin, we established a line cutaneous squamous cell carcinoma (SCC) cells, named ONSC, which lacks gene develops SCC syngeneic wild-type (WT) OPN-null mice. At 8 and/or 10 week after subcutaneous injection ONSC cells mice, however, there...
Asthma is one of the most common respiratory diseases. Although progress has been made in our understanding airway pathology and many drugs are available to relieve asthma symptoms, there no cure for chronic asthma. Plasminogen activator inhibitor 1 (PAI-1), a primary tissue-type urokinase-type plasminogen activators, pleiotropic functions besides suppression fibrinolysis. In this study, we show that administration TM5275, an orally effective small-molecule PAI-1 inhibitor, 25 days after...
To estimate the association between mean arterial pressure during pregnancy and neonatal outcomes in participants with chronic hypertension using data from CHAP (Chronic Hypertension Pregnancy) trial.
OBJECTIVE: To compare differences in postpartum blood pressure (BP) control (BP below 140/90 mm Hg) for participants with hypertension randomized to receive antihypertensive treatment compared no during pregnancy. METHODS: This study was a planned secondary analysis of multicenter, open-label, controlled trial (The CHAP [Chronic Hypertension and Pregnancy] trial). Pregnant mild chronic 160/105 were into two groups: active (antihypertensive treatment) or (no unless severe hypertension, BP Hg...
2023 Background: ABT-510 (Abbott Laboratories, Abbott Park, IL, USA) is a Thrombospondin-1 (TSP-1) mimetic drug with anti-angiogenic properties. This phase I dose escalation trial was designed to study the maximum tolerated (MTD) of ABT 510 when used concurrently temozolomide (TMZ) and radiotherapy (RT) in patients newly diagnosed glioblastoma multiforme (GBM). Methods: A total 23 diagnosed, histologically verified GBM were enrolled between April 2005 January 2007, after obtaining written...