A5001431526- Myasthenia Gravis and Thymoma
- Parkinson's Disease and Spinal Disorders
- Peripheral Neuropathies and Disorders
- Glycogen Storage Diseases and Myoclonus
- Dementia and Cognitive Impairment Research
- Botulinum Toxin and Related Neurological Disorders
- Genetics and Neurodevelopmental Disorders
- Amyotrophic Lateral Sclerosis Research
- Trace Elements in Health
- Hereditary Neurological Disorders
- Thyroid and Parathyroid Surgery
- Parkinson's Disease Mechanisms and Treatments
- Spinal Dysraphism and Malformations
- Nerve injury and regeneration
- Neurology and Historical Studies
- Lysosomal Storage Disorders Research
- Pituitary Gland Disorders and Treatments
- Antifungal resistance and susceptibility
- Immunodeficiency and Autoimmune Disorders
- Cerebrospinal fluid and hydrocephalus
- Neurosurgical Procedures and Complications
- Vascular Malformations and Hemangiomas
- Cerebral Palsy and Movement Disorders
- Trigeminal Neuralgia and Treatments
- Neurological disorders and treatments
George Washington University
2020
University of Alabama at Birmingham
2020
Hospital de Base
1989-2019
Universidade de Brasília
2016
Hospital de Base
2000-2014
Hospital Universitário de Brasília
1997
Instituto de Neurologia Y Neurocirugia
1992
Universidad de Londres
1988
Thymectomy has been a mainstay in the treatment of myasthenia gravis, but there is no conclusive evidence its benefit. We conducted multicenter, randomized trial comparing thymectomy plus prednisone with alone.We compared extended transsternal alternate-day alone. Patients 18 to 65 years age who had generalized nonthymomatous gravis disease duration less than 5 were included if they Myasthenia Gravis Foundation America clinical class II IV (on scale from I V, higher classes indicating more...
OBJECTIVES: To assess the epidemiologic characteristics of amyotrophic lateral sclerosis (ALS) in Brazil 1998. METHOD: Structured Clinical Report Forms (CRFs) sent to 2,505 Brazilian neurologists from January September 1998 be filled with demographic and clinical data regarding any ALS patient seen at time during that year. RESULTS: Five hundred forty CRFs were returned by 168 neurologists. Data on 443 patients meeting criteria probable or definite according El Escorial definition analysed:...
Congenital myasthenic syndrome (CMS) is a heterogeneous disorder that causes fatigable muscle weakness. CMS has been associated with variants in the MuSK gene and, to date, 16 patients have reported. MuSK-CMS present different phenotypic pattern of limb girdle Here, we describe four additional and discuss clinical relationship those previously Two novel damaging missense are described: c.1742T > A; p.I581N found homozygosis, c.1634T C; p.L545P compound heterozygosis p.R166*. The reported had...
<h3>Objective</h3> To examine whether sustained minimal manifestation status (MMS) with complete withdrawal of prednisone is better achieved in thymectomized patients myasthenia gravis (MG). <h3>Methods</h3> This study a post hoc analysis data from randomized trial thymectomy MG (Thymectomy Trial Non-Thymomatous Myasthenia Gravis Patients Receiving Prednisone Therapy [MGTX]). MGTX was multicenter, randomized, rater-blinded 3-year that followed by voluntary 2-year extension for acetylcholine...
To know the impact of Guillain Barré syndrome (GBS) in population less than 15 years old, after eradication poliomyelitis. Data bank from program epidemiological surveillance acute flaccid palsies (AFP) Fundação Nacional de Saúde were analyzed between 1990-1996. From 3619 notifications AFP there 1678 GBS. GBS yearly incidence rates is 0.39-0.63 cases/100,000. No consistent seasonal variation existed or relationship to vaccines. Weakness at inclusion were, moderate 52.1%, severe 47.9%, sixty...
Multiple sclerosis (MS) is an inflammatory, autoimmune, demyelinating, and degenerative central nervous system disease. Even though the etiology of MS has not yet been fully elucidated, there evidence that genetic environmental factors interact to cause Among main studied, those more likely associated with include certain viruses, smoking, hypovitaminosis D. This review aimed determine whether recommend use vitamin D as monotherapy or adjunct therapy in patients MS. We searched PUBMED,...
Abstract The spectrum of neuropsychiatric phenomena observed in amyotrophic lateral sclerosis (ALS) is wide and not fully understood. Disorders laughter crying stand among the most common manifestations. aim this study to report results an educational consensus organized by Brazilian Academy Neurology evaluate definitions, phenomenology, diagnosis, management disorders ALS patients. Twelve members - considered be experts field were recruited answer 12 questions about subject. After...
Os autores relatam o caso de uma paciente com espasmo hemifacial e impressão basilar associados a malformação Arnold-Chiari. Com descompressão cirúrgica da fossa posterior, empregada no tratamento basilar, houve melhora do quadro clínico se reduziu quanto à frequência, duração intensidade. É enfatizada necessidade etiológico hemifacial, antes recorrer toxina botulínica.
We collected 30 cases of vaccine associated paralytic poliomyelitis (VAPP) from 4081 acute flaccid palsies notified 1989 to 1995 the Brazilian Ministry Health. There were VAPP with 56% children younger than 1 year old, 56.7% female. 46% reported in Northeast. Ten P2 virus, 8 P3 and 2 P1 associations amongst them isolated. The clinical pattern 60 days was: monoplegia (16), paraplegia (6), tetraplegia (5), hemiplegia (2) triplegia (1). was no strong relationship between fever, before or after...
Após introdução sobre a etiopatogenia da miastenia grave e divergências quanto às várias modalidades terapêuticas, os autores mostram resultados favoráveis obtidos com timectomia isoladamente (13 casos): 15,3% remissão completa (2 de 13), 46,15% melhora importante (6 casos), 30,7% apenas um grau na escala atividade (4 casos). A associação corticosteróide e/ou plasmaferese elevou para 14,8% do total 27 casos); 74% apresentaram (20 7,4%, piora (dois casos) caso não apresentou resposta...
This study quantitates the major morphological and cytochemical changes in limb muscle biopsies from 37 patients with the, syndrome of chronic progressive external ophthalmoplegia (CPEO). The aim was to assess value biopsy diagnosis this syndrome; define myopathological determine whether there were any specific clinico-pathological correlations. Patients divided into three clinical groups - 11 CPEO facial and/or weakness; 10 weakness a positive family history; 16 one or more following:...
Os autores fazem estudo retrospectivo de 51 pacientes com síndrome Guillain-Barré, internados no Hospital Base do Distrito Federal 1974 a 1984. Dezoito desses doentes foram tratados corticosteróides (prednisona ou dexametasona) e os outros 33 não receberam esse tipo medicação. A evolução clínica (grau recuperação, seqüelas, complicações, causa mortis) o tempo internação são comparados nesses dois grupos. Conclui-se que corticoterapia alterou modo significativo da doença. Além disso, únicos...
Cinco casos de doença Lafora são relatados, dando-se ênfase à sequência eventos clínicos que permitiram a suspeita do diagnóstico e o posterior método comprovação através exames histopatológicos da pele fígado. Todos os pacientes iniciaram quadro clínico com diminuição rendimento escolar ou distúrbio memória, se seguiram crises convulsivas mioclonias. Ressalta-se caráter familiar doença, idade início entre 12 16 anos impossibilidade atingir um controle adequado das crises, mesmo utilizando...
Based on the fact that Brazilian ethnic groups are mixed and therefore different from caucasian, chinese or japanese populations authors studied HLA antigen distribution in 37 myasthenic patients. The control group consisted of 69 healthy individuals same population laboratory. antigens B8 showed highest relative risk for female, younger than 40 years old, with thymic hyperplasia. Also A1 high frequency black
This study quantifies the maior electron microscopic changes in limb muscle biopsies from 31 out of 34 patients with syndrome chronic progressive external ophthalmoplegia. Patients were divided into three clinical groups - A) 10 sporadic cases weakness only; B) 9 familial C) 15 and one or more following features: pigmentary retinopathy, cerebellar ataxia, pyramidal signs peripheral neuropathy. Electron mitochondrial abnormalities found all (8 group A, 3 B, 14 C). Quantitative measurements...