A5065009359- Pregnancy and preeclampsia studies
- Maternal and fetal healthcare
- Birth, Development, and Health
- Blood Pressure and Hypertension Studies
- Sulfur Compounds in Biology
- Facial Trauma and Fracture Management
- Global Maternal and Child Health
- Folate and B Vitamins Research
- Drug-Induced Hepatotoxicity and Protection
- Evaluation and Performance Assessment
- Cardiovascular Issues in Pregnancy
- Liver physiology and pathology
- Cleft Lip and Palate Research
- Liver Disease Diagnosis and Treatment
- Innovations in Medical Education
- Health disparities and outcomes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Delphi Technique in Research
- Alcohol Consumption and Health Effects
- Interprofessional Education and Collaboration
- Maternal and Perinatal Health Interventions
- Pharmacogenetics and Drug Metabolism
- Youth Education and Societal Dynamics
- Craniofacial Disorders and Treatments
- Problem and Project Based Learning
University of Alabama at Birmingham
2020-2023
Naval Medical Center Portsmouth
2017
University of Washington
1985
The effects of acetaminophen and its major toxic metabolite, N-acetyl-p-benzoquinone imine (NAPQI), have been investigated in hepatocytes isolated from 3-methylcholanthrene-pretreated -untreated rats, respectively. two compounds produced qualitatively similar changes although the quinone was with shorter incubations periods at lower doses. Both agents caused an elevation cytosolic Ca2+, assessed by phosphorylase a activity, which accompanied concomitant appearance plasma membrane blebs. A...
A highly purified plasma membrane fraction isolated from rat hepatocytes was found to catalyze the hydrolysis of ATP in response micromolar concentrations glutathione disulfide (GSSG).This process exhibited distinct kinetic parameters suggesting existence both a high and low affinity component.The apparent K , values (GSSG) for were 140 PM 1 m M components, respectively.Disulfides other than GSSG also stimulate hydrolysis.The similarity between properties GSSGstimulated ATPase those reported...
To estimate the association between mean arterial pressure during pregnancy and neonatal outcomes in participants with chronic hypertension using data from CHAP (Chronic Hypertension Pregnancy) trial.
Objective This study was aimed to examine differences in infant mortality outcomes across maternal age subgroups less than 20 years the United States with a specific focus on racial and ethnic disparities. Study Design Using National Center for Health Statistics cohort-linked live birth–infant death files (2009-2013) this cross-sectional study, we calculated descriptive statistics by (<15, 15–17, 18–19 years) racial/ethnic (non-Hispanic white [NHW], non-Hispanic black [NHB], Hispanic)...
The incidence of hypertensive disorders pregnancy (HDP) are on the rise in United States, especially South, which has a heavy chronic disease burden and large number Medicaid nonexpansion states. Sizeable disparities HDP outcomes exist by race/ethnicity, geography, health insurance coverage. Our objective is to explore Alabama maternity population, association maternal sociodemographic, clinical, care utilization characteristics with diagnosis.
The Ideal Life Blood Pressure Manager measures blood pressure (BP) and automatically transmits results to the patient's medical record independent of internet access, but has not been validated. Our objective was conduct a validation study BP in pregnant women using protocol.Pregnant participants were enrolled into three subgroups per Association for Advancement Medical Instrumentation/European Society Hypertension/International Organization Standardization protocol: normotensive (systolic...
Objective Hypertensive disorders of pregnancy (HDP) contribute significantly to the development severe maternal morbidities (SMM), particularly among low-income women. The purpose study was explore relationship between characteristics and SMM, investigate if differences in SMM exist patients with HDP diagnosis. Study Design This utilized 2017 Alabama Medicaid administrative claims. diagnoses were captured using Centers for Disease Control Prevention's classification by International...
Background and Objectives: Public health systems exhibiting strong connections across the workforce experience substantial population improvements. This is especially important for improving quality achieving value among vulnerable populations such as mothers infants. The purpose of this research was to demonstrate how Alabama's newly formed perinatal collaborative (Alabama Perinatal Quality Collaborative [ALPQC]) used evidenced-based processes achieve consensus in identifying improvement...
Accurate vital statistics data are critical for monitoring population health and strategizing public interventions. Previous analyses of statewide birth have identified several factors that may reduce certificate accuracy including systematic errors limited review by clinicians. The aim this initiative was to increase the proportion hospitals in Alabama reporting accurate from 67% 87% within 1 year.The Perinatal Quality Collaborative led collaborative effort. Process measures included...
INTRODUCTION: The effect of race and ethnicity on outcomes in the treatment mild chronic hypertension (cHTN) pregnancy is unknown. METHODS: This was a secondary analysis multicenter randomized trial pregnant patients with cHTN comparing antihypertensive therapy to goal blood pressure less than 140/90 mm Hg (Active) versus usual care. Log-binomial regression assessed differences between racial ethnic groups among Active participants. Outcomes included composite (preeclampsia severe features,...