A5086536497- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pneumonia and Respiratory Infections
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Tuberculosis Research and Epidemiology
- Sarcoidosis and Beryllium Toxicity Research
- Respiratory viral infections research
- Nosocomial Infections in ICU
- Medical Imaging and Pathology Studies
- Antifungal resistance and susceptibility
- Asthma and respiratory diseases
- Mycobacterium research and diagnosis
- Fungal Infections and Studies
- Cardiac Imaging and Diagnostics
- Inhalation and Respiratory Drug Delivery
- Tracheal and airway disorders
- Dysphagia Assessment and Management
- Antibiotics Pharmacokinetics and Efficacy
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Cystic Fibrosis Research Advances
- Infectious Diseases and Mycology
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Obstructive Sleep Apnea Research
- Eosinophilic Disorders and Syndromes
Nagasaki Medical Center
2011-2025
Oita University
2015-2024
Bay Medical Center
2024
Weatherford College
2022
Tenshi Hospital
2022
Oita University of Nursing and Health Sciences
2021
Oita University Hospital
2008-2019
National Kinki Chuo Hospital for Chest Disease
2019
Keimyung University Dongsan Medical Center
2019
Keimyung University
2019
Recently, "low-dose and long-term" erythromycin treatment has been reported as effective on diffuse panbronchiolitis (DPB), but its mechanism is still obscure. Patients with DPB were found to have significantly higher percentages of neutrophils in the pre-erythromycin bronchoalveolar lavage fluid (BALF) than healthy nonsmoking volunteers (p < 0.001). They showed a significant reduction BALF neutrophil after 0.01). The chemotactic activity (NCA) was elevated obtained from 19 patients compared...
BackgroundHuman herpesvirus 6 (HHV-6) is increasingly recognized as an opportunistic and potentially life-threatening pathogen in recipients of allogeneic stem cell transplants (SCTs) MethodsTo clarify the incidence clinical relevance active HHV-6 infection, serial titers plasma DNA were determined for 50 SCT recipients, using real-time polymerase chain reaction ResultsHHV-6 was detected from 24 patients (48%). most frequently apparent ∼14–27 days after transplantation. An increased risk a...
The epidemiology of human herpesvirus 6 (HHV-6) encephalitis after allogeneic hematopoietic cell transplantation (HCT) and its relationship with HHV-6 reactivation have not been sufficiently characterized. This prospective, multicenter study 230 HCT recipients investigated the encephalitis. Plasma DNA load was prospectively evaluated twice weekly until 70 days HCT. Cumulative incidence positive high-level (plasma ≥104 copies/mL) at day 72.2% 37.0%, respectively. Multivariate analysis...
Shigeru Kohno, Yoshifumi Imamura, Yuichiro Shindo, Masafumi Seki, Tadashi Ishida, Shinji Teramoto, Junichi Kadota, Kazunori Tomono, Akira Watanabe Unit of Molecular Microbiology and Immunology, Nagasaki University, Graduate School Biomedical Sciences, 1-7-1 Sakamoto, Nagasaki, 852-8501 Japan Institute for Advanced Research, Nagoya Department Respiratory Medicine, Division Infection Control Prevention, Osaka University Hospital, Kurashiki Central Hitachinaka Medical Education Research Center,...
<b><i>Background:</i></b> We analyzed the pharmacokinetic-pharmacodynamic relationship of vancomycin to determine drug exposure parameters that correlate with efficacy and nephrotoxicity in patients methicillin-resistant <i>Staphylococcus aureus</i> pneumonia evaluated need use peak concentration therapeutic monitoring (TDM). <b><i>Methods:</i></b> Serum concentrations 31 hospitalized treated for <i>S. were collected....
Heat shock protein (HSP) 47, a collagen-specific molecular chaperone, is involved in the processing and/or secretion of procollagen. The present study was undertaken to investigate whether treatment with antifibrotic drug pirfenidone attenuates bleomycin (BL)‐induced overexpression HSP47 lungs. Male ICR mice were intravenously injected BL or saline (SA). Pirfenidone control (CD) administered 14 days after commencement SA, and continued throughout course experiment. randomly divided into...
Influenza virus infections are known to persist longer in patients with underlying diseases, including respiratory tract and tend become complicated by secondary influenza-associated infections, such as pneumonia. To assess the efficacy safety of novel anti-influenza drug peramivir high-risk patients, we conducted a clinical trial diabetes or chronic diseases being treated drugs that suppress immune function. In this multicenter, uncontrolled, randomized, double-blind study, was...
Aspiration pneumonia is one of the common presentations community-acquired (CAP) and healthcare-associated (HCAP). However, its significance has not yet been fully evaluated due to difficulties associated with diagnosis this condition. This study aimed evaluate impact objectively defined aspiration on patients' prognosis CAP HCAP.This a multicenter retrospective cohort consisting 417 220 HCAP patients. We as having both risk factors for (dysphagia neurological disorder, or disturbance...
The natural course of idiopathic pulmonary fibrosis (IPF) is variable. Predicting disease progression and survival in IPF important for treatment. We previously demonstrated that serum periostin has the potential to be a prognostic biomarker IPF. Our aim was use monomeric multicenter study evaluate its efficacy diagnosing predicting progression. To do so, we developed new kit detect only periostin. subjects consisted 60 patients cohort study. applied periostin, total detected by conventional...
The features of chronic airway diseases, including bronchitis, cystic fibrosis, bronchiectasis, and diffuse panbronchiolitis, include bacterial infection obstruction by mucus. Pseudomonas aeruginosa is one the most common pathogens in lung infection, quorum-sensing systems contribute to pathogenesis this disease. signal molecule [N-(3-oxododecanoyl) homoserine lactone (3O-C(12)-HSL)] not only regulates virulence but also associated with immune response. In study, we investigated whether...
Previous studies established that variable degrees and types of glycosylation can account for differences in the ability CD44 to function as a receptor hyaluronic acid. We have now used neuraminidase treatment conclude sialylation negatively regulates on human monocytic cell line THP-1 peripheral blood monocytes. Both these displayed increased activity after overnight culture with LPS. Of particular interest, sialidase inhibitor 2-deoxy-2, 3-dehydro-N-acetylneuraminic acid completely blocked...
Defensins are cysteine-rich cationic antimicrobial peptides that play an important role in innate immunity and known to contribute the regulation of host adaptive immunity. In addition direct activities, it has been recently reported α-defensins, mainly present neutrophils lung, have a cytotoxic effect induce IL-8 production from airway epithelial cells. Although β-defensins expressed cells various tissues, including there no reports their effects on cytokine synthesis The aim study was...
The aim of the present study was to elucidate effect macrolide antibiotic azithromycin on Pseudomonas aeruginosa. We studied susceptibility in P. aeruginosa PAO1 using a killing assay. cells at exponential growth phase were resistant azithromycin. In contrast, stationary sensitive divalent cations Mg2+ and Ca2+ inhibited this activity, suggesting that action is mediated by interaction with outer membranes cells, since exist between adjacent lipopolysaccharides (LPSs) stabilize membrane....
Aim: No large case series has so far shown the chest computed tomography (CT) features in patients with aspiration pneumonia, despite fact that pneumonia is most common pulmonary disease elderly and regarded as gravity‐dependent pneumonia. The aim of present study was to elucidate CT based on patients' status dysphagia‐associated Methods: A total 53 patients, who were hospitalized because subsequently confirmed have dysphagia by videofluorography, entered into this study. findings...