A5084686688- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Bladder and Urothelial Cancer Treatments
- Pharmacological Effects and Toxicity Studies
- Polyomavirus and related diseases
- Viral-associated cancers and disorders
- Cytomegalovirus and herpesvirus research
- Renal Transplantation Outcomes and Treatments
- Pharmacogenetics and Drug Metabolism
- Esophageal and GI Pathology
- Folate and B Vitamins Research
- Minimally Invasive Surgical Techniques
- Urologic and reproductive health conditions
- Vascular Malformations and Hemangiomas
- Hormonal Regulation and Hypertension
- Drug Transport and Resistance Mechanisms
- Pituitary Gland Disorders and Treatments
- Adrenal and Paraganglionic Tumors
- Ovarian cancer diagnosis and treatment
- Cholesterol and Lipid Metabolism
- Tuberous Sclerosis Complex Research
- Uterine Myomas and Treatments
- Cancer Immunotherapy and Biomarkers
- Hormonal and reproductive studies
Oita University
2013-2025
Oita University Hospital
2012-2024
Tianjin Nankai Hospital
2014
Oita Prefectural Hospital
2007-2009
Kitasato University
2006
Imbalance between gastrointestinal peptides has been implicated as a cause of chemotherapy-induced nausea and vomiting (CINV) anorexia in cancer patients. This study comprehensively evaluated the changes blood levels five peptide: substance P, neuropeptide (NPY), motilin, ghrelin leptin, following chemotherapy, relationship these CINV or anorexia. single-center, prospective, observational recruited 20 patients with esophageal cancer, urothelial testiculoma undergoing cisplatin-based...
Abstract Background BK virus (BKV), JC virus, and simian 40 (SV40) are polyomaviruses with high genome identity. Therefore, SV40 staining is used for immunostaining to detect such as BKV. BKV reactivation has been reported be a risk high-grade bladder cancer in immunosuppressed kidney transplant patients. We report patient staining-positive muscle invasive cancer. Case presentation The was 74-year-old woman who received transplantation China 17 years prior. After the age of 71 years, decoy...
Abstract Organic anion‐transporting polypeptides (OATP)1B are drug transporters mainly expressed in the sinusoidal membrane. Many studies have suggested that OATP1B activity is affected by genetic factor, uremic toxin 3‐carboxy‐4‐methyl‐5‐propyl‐2‐furanpropanoic acid (CMPF), and inflammatory cytokines, such as tumor necrosis factor‐α (TNF‐α) interleukin‐6 (IL‐6). Coproporphyrin‐I (CP‐I) spotlighted a highly accurate endogenous substrate of OATP1B. We previously reported positive correlation...
Abstract Plasma 4β‐hydroxycholesterol (OHC) has drawn attention as an endogenous substrate indicating CYP3A activity. 4β‐OHC is produced by hydroxylation CYP3A4 and CYP3A5 cholesterol autoxidation. 4α‐OHC autoxidation not affected This study aimed to evaluate the usefulness of plasma concentration minus (4β‐OHC–4α‐OHC) compared with 4β‐OHC/total (TC) ratio in cross‐sectional evaluation Four hundred sixteen general adults were divided into 191 CYP3A5*1 carriers 225 non‐carriers. Twenty‐six...
4β-Hydroxycholesterol (4β-OHC) is formed by Cytochrome P450 (CYP)3A and has drawn attention as an endogenous phenotyping probe for CYP3A activity. However, 4β-OHC also increased cholesterol autooxidation occurring in vitro due to dysregulated storage vivo oxidative stress or inflammation, independent of 4α-hydroxycholesterol (4α-OHC), a stereoisomer 4β-OHC, via cholesterol, not CYP3A, thus may have clinical potential reflecting the state autooxidation. In this study, we establish sensitive...
Infected urachal remnant is an uncommon benign disease but generally symptomatic and commonly recurs. The standard of care for this complete resection all anomalous tissue including a bladder cuff to avoid recurrence. Recent minimally invasive laparoscopic techniques can effectively manage disease, multiport are reported still leave scars outside the umbilicus.A novel technique umbilical laparoendoscopic single-site (LESS) surgery 2 patients with presented in study.In both cases, entire...
Indoxyl sulfate and 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid are uremic toxins that accumulate in renal failure have been reported to decrease the activities of drug-metabolizing enzyme cytochrome P450 3A drug transporter organic anion transporting polypeptides 1B, respectively. In this study, we established validated an assay for simultaneous quantification indoxyl human plasma. The samples were pretreated by solid-phase extraction, measured ultra-high-performance liquid...
We present a first case report of an IL-6-producing pheochromocytoma associated with von Hippel Lindau (vHL) disease. Pheochromocytomas are rare tumors that produce catecholamines, leading to various symptoms. In this case, 28-year-old woman family history vHL disease presented prolonged fever. Laboratory examinations revealed elevated C-reactive protein levels, and notably, significantly increased serum IL-6 level. Imaging studies confirmed bilateral adrenal uptake on...
Lymphoepithelioma-like carcinoma (LELC) in the bladder is uncommon with a reported incidence of 0.4%–1.3% all carcinomas. In Japan, some occurrences LELC have been renal pelvis and ureter but only two bladder. A tumor was identified 70-year-old man suffering from macroscopic hematuria for 2 months. Sections transurethral resection showed invasive high-grade urothelial carcinoma. The patient diagnosed local tumor, cystectomy ileal conduit formation performed. final pathological evaluation...
A combinatorial human Fab library was constructed using RNAs from peripheral blood lymphocytes of 6 rabies vaccine-boosted volunteers pComb3X phagemid vector. The size the approximately 7.0 x 10(7) Escherichia coli transformants. selected against purified virus (RV) virion or RV glycoprotein for isolation phages displaying RVneutralizing antibody. Among 132 clones, two preparations revealed neutralizing activities strain CVS when assayed in rapid fluorescent focus inhibition test (RFFIT)....
Because tacrolimus is predominantly metabolized by CYP3A, the blood concentration/dose (C/D) ratio affected CYP3A5 polymorphism. Parathyroid hormone (PTH) expression increases in secondary hyperparathyroidism, which frequently associated with end-stage renal disease. Recently, PTH has been shown to downregulate CYP3A at mRNA level. In this study, we examined influence of polymorphism on and association serum intact-PTH (iPTH) level concentration patients disease just before kidney...
Abstract A 31‐year‐old, previously normotensive healthy man developed right flank pain and was admitted to a medical service. Right renal infarction suspected by enhanced abdominal computed tomography (CT) arteriography. Fourteen days after the onset, he transferred Oita University Hospital, Oita, Japan. Renal angiography revealed an isolated artery dissection causing atrophy due main stem narrowing of artery. Renogram scintigram with 99m Tc‐diethylene triamine pentaacetic acid remarkable...
Parathyroid allotransplantation is a burgeoning treatment for severe hypoparathyroidism. Deceased donor parathyroid gland (PTG) procurement can be technically challenging due to lack of normal intraoperative landmarks and exposure constraints in the neck organ donors. In this study, we assessed standard 4-gland situ en bloc surgical techniques PTG ex vivo near-infrared autofluorescence (NIRAF) imaging identification PTGs during recovery.Research tissue consent was obtained from donors or...
Laparoendoscopic single-site surgery is a recently innovated urologic surgical procedure. Transumbilical laparoendoscopic adrenalectomy (LESS-A) technically safe and feasible in patients with benign adrenal tumors. To improve patient counseling informed consent, we evaluated patient-reported postoperative pain, body image, cosmetic satisfaction after transumbilical LESS-A.We reviewed 24 who underwent LESS-A assessed their operative esthetic outcomes incisional pain. Incisional pain was using...
This paper presents a tensile stress evaluation of steel plates by chaos Barkhausen noise. The magnetic materials affects domains, so the amount can be evaluated noise is very complicated signal, special method needed to use it. quantitative change after test found fractal dimension chaotic attractors constructed measured
Abstract Background In prostate cancer treatment, lower urinary tract symptoms significantly improve with luteinizing hormone-releasing hormone antagonists use compared agonists. However, it is unclear whether can decrease acute toxicity during external beam radiotherapy. This study aimed to assess used as neoadjuvant therapy reduced radiotherapy Methods The included 78 patients who underwent intensity-modulated radiation for intermediate- and high-risk between April 2013 January 2020....
A 74-year-old woman presenting with bilateral ureteral stricture was referred to our hospital. She had undergone radical hysterectomy and adjuvant irradiation therapy for cervical cancer in 2000. Double-J stents were inserted both the ureters replaced at regular intervals. Eighteen months after stenting, she complained of gross hematuria managed hemostatic agents. During a routine replacement right double-J stent, massive bleeding observed from urethra which continued intermittently. The...
We report here a case of recurrent pheochromocytoma successfully managed by laparoscopic surgery in patient with multiple endocrine neoplasia type 2A. A 25-year-old man presented the contralateral adrenal mass after earlier right adrenalectomy. For preoperative diagnosis left pheochromocytoma, sparing was considered. From intraoperative view, we found that tumor originated periadrenal sympathetic ganglia, and excision paraganglioma performed preserved integrity normal gland. Extra-adrenal is...
Skene's gland cysts are rare and the cause of adult-onset is still unclear. We report case a 34-year-old woman developing cyst following history various gynecological treatment interventions. She finally underwent surgical excision no recurrence has been observed 1 year after surgery.
Mycophenolic acid (MPA) undergoes enterohepatic circulation. A kidney transplant patient on mycophenolate mofetil was treated with tazobactam/piperacillin for pyelonephritis, and developed antimicrobial-associated diarrhea. Consequently, the MPA trough level decreased by approximately 90%. Furthermore, it took a month to normalize even after diarrhea had resolved.