A5073702015- Electrospun Nanofibers in Biomedical Applications
- Natural Compound Pharmacology Studies
- Oral Health Pathology and Treatment
- Oral and gingival health research
- Synthesis of Organic Compounds
- Dermatological and COVID-19 studies
- Oral microbiology and periodontitis research
- Oral and Maxillofacial Pathology
- Protease and Inhibitor Mechanisms
- Advanced Sensor and Energy Harvesting Materials
- Dental materials and restorations
- NF-κB Signaling Pathways
- Endodontics and Root Canal Treatments
- dental development and anomalies
- Forensic Anthropology and Bioarchaeology Studies
- Silk-based biomaterials and applications
- Dental Radiography and Imaging
- Genital Health and Disease
- Advanced Drug Delivery Systems
- Pharmacological Effects and Toxicity Studies
- Biological Activity of Diterpenoids and Biflavonoids
- Autoimmune and Inflammatory Disorders
- Carbohydrate Chemistry and Synthesis
- Medicinal Plants and Neuroprotection
- HIV/AIDS oral health manifestations
Naresuan University
2013-2023
Naresuan University Hospital
2021
Chulalongkorn University
2006-2010
This study was conducted to examine the activity of alpha-mangostin against Candida albicans, most important microorganism implicated in oral candidiasis. Its compared Clotrimazole and Nystatin. Results showed that effective C. minimum inhibitory concentration (MIC) fungicidal (MFC) were 1,000 2,000 microg/ml, respectively. The albicans killing more than cytotoxicity determined it found at 4,000 microg/ml not toxic human gingival fibroblast for 480 min. strong antifungal low toxicity make a...
Thin films of bacterial cellulose (BC) from a nata de coco culture system were developed, characterized, and investigated for the growth human keratinocytes fibroblasts. The average pore diameter total surface area dried BC estimated by BET 224 A 12.62 m(2)/g, respectively. With an film thickness 0.12 mm, tensile strength break strain 5.21 MPa 3.75%, whereas those wet 1.56 8.00%, water absorption capacity air-dried was 5.09 g water/g films. For uses in therapy skin wounds, potential...
This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning solutions different solvent [dimethylformamide (DMF) and ethyl alcohol (EtOH)] was performed. Prepared films were evaluated for morphology, physical, mechanical properties. MX content, dissolving time, release, cytotoxicity investigated. In vivo studies also performed in healthy human...
Understanding the tumor immune microenvironment is becoming increasingly necessary for risk prediction and treatment selection. In particular, oral cancer has various immunosuppressive characteristics in microenvironment. Therefore, we comprehensively assessed profiles of tongue squamous cell carcinoma (OTSCC).Multiplex immunofluorescence tissue imaging analyses were performed to evaluate at invasive front 60 OTSCC surgical specimens. We analyzed 58 parameters including density proportion...
The aim of this study was to investigate the antibacterial activity against Enterococcus faecalis alpha-mangostin and compare its with sodium hypochlorite (NaOCl) chlorhexidine (CHX) as well assess biocompatibility using human periodontal ligament (PDL) cell. Alpha-mangostin extracted from pericarps mangosteen by thin layer chromatography. inhibitory effect on E. determined cultures an applied broth dilution test. rate bactericidal evaluated time-kill. Human PDL cell culture used...
Oral lichen planus (OLP) is a chronic inflammatory disease of the skin and mucous membrane presented with various clinical appearances. The aim present study was to elucidate profile patients OLP.The dental records 102 who visited Medicine Clinic, Dental Hospital, Naresuan University during 2002-2018 were retrospectively reviewed.There 75 (73.5%) women 27 (26.5%) men, giving female male ratio 2.8:1. age OLP ranged 20-81 years old mean 56.4 ± 13.2 old. Seventy-eight (76.5%) had history...
The aim of this study was to develop erythrosine-loaded electrospun polyvinyl pyrrolidone/ hydroxypropyl-β-cyclodextrin (PVP/HPβCD) fiber patches for plaque disclosing.The had been fabricated via electrospinning process and were characterized using scanning electron microscope (SEM), Fourier transform infrared spectrophotometry (FT-IR), differential calorimeter (DSC) powder X-ray diffractometry (PXRD).The then further evaluated wetting integration abilities, mechanical properties, loading...
Objective: Candida-associated denture stomatitis is a very common disease affecting wearers. It characterized by the presence of yeast biofilm on denture, primarily associated with C. albicans. The investigation agents that can reduce albicans adhesion may represent significant advancement in prevention and treatment this disease. This study aims to investigate effect alpha-mangostin vitro acrylic germ tube formation compare its activity clotrimazole which topical antifungal agent commonly...
Abstract Objectives The aim of this study is to evaluate the inhibitory effects M. alba stem extract (MSE) on expression matrix metalloproteinases (MMP)-1, MMP-9, and tissue inhibitors metalloproteinase (TIMP)-1 in Porphyromonas gingivalis lipopolysaccharide (LPS)-activated-acute monocytic leukemia cell line (THP-1). Materials Methods THP-1 cells were treated with noncytotoxic concentrations MSE combined 1 µg/mL P. LPS. mRNA levels MMP-1, TIMP-1 evaluated via quantitative real-time...