A5056797378- Axon Guidance and Neuronal Signaling
- Apelin-related biomedical research
- Biomarkers in Disease Mechanisms
- Cancer Risks and Factors
- Kruppel-like factors research
- Lymphatic System and Diseases
- Angiogenesis and VEGF in Cancer
- Nuclear Receptors and Signaling
- Cancer Cells and Metastasis
- Estrogen and related hormone effects
- Fibroblast Growth Factor Research
- Wnt/β-catenin signaling in development and cancer
- Immune cells in cancer
- Inflammatory mediators and NSAID effects
- Prostate Cancer Treatment and Research
- Reproductive System and Pregnancy
- Mesenchymal stem cell research
- Cancer, Stress, Anesthesia, and Immune Response
- Birth, Development, and Health
- Breast Cancer Treatment Studies
- Proteoglycans and glycosaminoglycans research
- Epigenetics and DNA Methylation
- FOXO transcription factor regulation
- Galectins and Cancer Biology
- Signaling Pathways in Disease
University of Colorado Anschutz Medical Campus
2015-2025
University of Colorado Cancer Center
2013-2025
University of Colorado Denver
2015-2025
Gates (United States)
2023
Colorado School of Public Health
2011
Cornell University
2007
Previous studies report conflicting data on outcomes of pregnancy-associated breast cancer (PABC). Our aim was to examine the effect a postpartum diagnosis maternal prognosis in young women's cohort. We conducted retrospective cohort study women age ≤45 years, diagnosed with (n = 619) during 1981-2011 at University Colorado Hospital and The Shaw Cancer Center Edwards, CO. Breast cases were grouped according time between giving birth diagnosis: nulliparous 125), pregnant 24), < 5 years 136),...
Tumor-associated macrophages (TAM) in the tumor microenvironment (TME) cooperate with cancer stem cells (CSC) to maintain stemness. We recently identified cluster of differentiation 44 (CD44) as a surface marker defining head and neck squamous cell carcinoma (HNSCC) CSC. PI3K-4EBP1-SOX2 activation signaling regulate CSC properties, yet upstream molecular control this pathway mechanisms underlying cross-talk between TAM HNSCC remain largely unknown. Because CD44 is mediator TME, we propose...
Breast involution following pregnancy has been implicated in the high rates of metastasis observed postpartum breast cancers; however, it is not clear how this remodeling process promotes metastasis. Here, we demonstrate that human cancers have increased peritumor lymphatic vessel density correlates with frequency lymph node metastases. Moreover, was normal tissue compared from nulliparous women. In rodents, mammary lymphangiogenesis upregulated during weaning-induced gland involution....
Reduction in breast cancer risk attributed to early-age pregnancy is mediated part by changes the mammary epithelium. Here, we address role of stroma this protection. Utilizing tumor cells capable transitioning from indolent proliferative/invasive states, demonstrate that extracellular matrix parous rats (parous matrix) decreases growth and impedes cellular phenotypes associated with cell invasion compared nulliparous matrix. Proteomic analysis identifies increased abundance collagen I...
<h3>Importance</h3> In women 45 years or younger, breast cancer diagnosis after childbirth increases the risk for metastasis and death, yet limited data exist to define this window of associated prognostic factors. <h3>Objective</h3> To assess elevated following a postpartum (PPBC) whether clinical factors are with increased risk. <h3>Design, Setting, Participants</h3> This multicenter cohort study conducted using cases from Colorado Young Women's Breast Cancer Cohort diagnosed between...
Abstract Postpartum mammary gland involution is a tissue remodeling event that occurs in all mammals the absence of nursing or after weaning to return pre-pregnant state. The microenvironment created by has proven be tumor promotional. Here we report GPI-linked protein semaphorin 7A (SEMA7A) expressed on epithelial cells during and use preclinical models demonstrate tumors induced express high levels SEMA7A. Overexpression SEMA7A promoted presence myeloid-derived podoplanin (PDPN)-expressing...
ABSTRACT Invadopodia formation and extracellular matrix degradation are key events during cancer cell invasion, yet little is known about mechanisms mediating these processes. Here, we report that Rab40b plays a role in invadopodia function breast invasion. We also identify Tks5 (also as SH3PXD2A), Src kinase substrate, new effector protein show functions tether mediates Rab40b-dependent targeting of transport vesicles containing MMP2 MMP9 to the extending invadopodia. Importantly,...
For many solid tumors, immune checkpoint blockade therapy has become first line treatment, yet a large proportion of patients with immunologically cold tumors do not benefit due to the paucity tumor infiltrating lymphocytes. Here we show that orphan G Protein-Coupled Receptor 182 (GPR182) contributes immunotherapy resistance in cancer via scavenging chemokines are important for lymphocyte recruitment tumors. GPR182 is primarily upregulated melanoma-associated lymphatic endothelial cells...
Summary Postpartum mammary gland remodeling after a pregnancy/lactation cycle is characterized by mechanisms of immunosuppression. Here we show that SEMA7A promotes PD-L1 expression in immune cells the tissue during involution. These same phenotypes are mimicked microenvironment SEMA7A-expressing tumors, which partially respond to αPD-1/αPD-L1 treatments vivo. However, remain treatment enriched for expression. Therefore, tested novel monoclonal antibody directly targets part, reducing...
ABSTRACT Chimeric poliovirus RNAs, possessing the 5′ nontranslated region (NTR) of hepatitis C virus in place NTR poliovirus, were used to examine role viral replication. The chimeric RNAs incubated cell-free reaction mixtures capable supporting sequential translation and replication RNA. Using preinitiation RNA complexes formed these reactions, we demonstrated that 3′ was insufficient, by itself, recruit proteins required for negative-strand synthesis. 5′-terminal cloverleaf cis form...
Abstract Introduction The functional unit of the mammary gland has been defined as epithelial cell plus its microenvironment, a hypothesis that predicts changes in function will be accompanied by concurrent stroma. To test this hypothesis, question was addressed whether stroma is functionally altered anti-oestrogen drug tamoxifen. Methods Forty female rats at 70 days age were randomised to two groups 20 and treated with 1.0 mg/kg tamoxifen or vehicle subcutaneously daily for 30 days,...
The Journal of Cancer Metastasis and Treatment is an open access journal focused on cancer metastasis treatment, including the occurrence, development, progression, metastasis, treatment oncologic disease. It covers basic, translational clinical research related to cell biology, genomics, precision medicine, oncology internal radiotherapy radiology, obstetrics gynecology, pediatrics, surgery, hematology, neurooncology, etc.
Abstract Approximately 70% of all breast cancers are estrogen receptor–positive (ER+ cancer), and endocrine therapy has improved survival for patients with ER+ cancer. However, up to half these tumors recur within 20 years. Recurrent develop resistance therapy; thus, novel targets needed treat recurrent Here we report that semaphorin 7A (SEMA7A) confers significantly decreased patient rates in SEMA7A was hormonally regulated cancer, but its expression did not uniformly decrease antiestrogen...
Abstract Background Extracellular vesicles (EVs) are small membrane particles that contribute to cancer progression and metastases by transporting biologically significant proteins nucleic acids. They may also serve as biomarkers of various disease states or important therapeutic targets. Breast EVs have the potential change behavior other cells in their microenvironment. However, proteomic content isolated from young women’s breast patients mechanisms underlying influence on tumor cell not...