A5068993156- Cancer Risks and Factors
- Cancer, Stress, Anesthesia, and Immune Response
- Reproductive System and Pregnancy
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Gastric Cancer Management and Outcomes
- Estrogen and related hormone effects
- Cancer Cells and Metastasis
- Helicobacter pylori-related gastroenterology studies
- Inflammatory mediators and NSAID effects
- Phagocytosis and Immune Regulation
- Immune Cell Function and Interaction
- Elder Abuse and Neglect
- Birth, Development, and Health
- Wnt/β-catenin signaling in development and cancer
- Biomarkers in Disease Mechanisms
- Metastasis and carcinoma case studies
- Cell death mechanisms and regulation
- Cytokine Signaling Pathways and Interactions
- Inflammation biomarkers and pathways
- Bone and Dental Protein Studies
- Particle Dynamics in Fluid Flows
- Immune Response and Inflammation
- RNA modifications and cancer
- Kruppel-like factors research
University of Alaska Anchorage
2015-2025
Alaska Native Medical Center
2018
Mayo Clinic
2018
University of Colorado Cancer Center
2010-2014
University of Colorado Denver
2010-2014
University of Colorado Anschutz Medical Campus
2011-2014
The Medical Center of Aurora
2012
University of Wisconsin–Madison
2011
Mammary gland development is dependent on macrophages, as demonstrated by their requirement during the expansion phases of puberty and pregnancy. Equally dramatic tissue restructuring occurs following lactation, when regresses to a state that histologically resembles pre-pregnancy through massive programmed epithelial cell death stromal repopulation. Postpartum involution characterized wound healing-like events, including an influx macrophages with M2 characteristics. Macrophage levels peak...
Women diagnosed with breast cancer within 5 years postpartum have poor survival rates. The process of mammary gland involution, whereby the lactating remodels to its prepregnant state, promotes progression in xenograft models. Macrophage influx occurs during implicating immune modulation promotion cancer. Herein, we characterize murine and find an orchestrated cells similar that which wound healing. Further, normal involuting may be immunosuppressed state as discerned by transient presence...
Breast involution following pregnancy has been implicated in the high rates of metastasis observed postpartum breast cancers; however, it is not clear how this remodeling process promotes metastasis. Here, we demonstrate that human cancers have increased peritumor lymphatic vessel density correlates with frequency lymph node metastases. Moreover, was normal tissue compared from nulliparous women. In rodents, mammary lymphangiogenesis upregulated during weaning-induced gland involution....
Acute myeloid leukemia (AML) continues to be extremely difficult treat successfully, and the unacceptably low overall survival rates mandate that we assess new potential therapies ameliorate poor clinical response conventional therapy. Abnormal tyrosine kinase activation in AML has been associated with prognosis provides strategic targets for novel therapy development. We found Mer receptor was over-expressed a majority of pediatric (29/36, 80%) adult (10/10, 100%) primary patient blasts at...
Women diagnosed with breast cancer within 5 years postpartum (PPBC) have poorer prognosis than age matched nulliparous women, even after controlling for clinical variables known to impact disease outcomes. Through rodent modeling, the poor of PPBC has been attributed physiologic mammary gland involution, which shapes a tumor promotional microenvironment through induction wound-healing-like programs including myeloid cell recruitment. Previous studies utilizing immune compromised mice shown...
Objectives/Goals: The Clinical and Translational Research (CTR) pathway aims to increase the number of health science professionals participating in CTR their careers throughout WWAMI Region (Washington, Wyoming, Alaska, Montana, Idaho). Methods/Study Population: first cohort thirty-one students started January 2024 were organized into three groups that met weekly. One in-person group Anchorage, AK; one Seattle, WA; a from across region convened virtually. Students completed year-long series...
Background: Mucin-1 (MUC1) is a glycoprotein that hypoglycosylated and overexpressed in most adenocarcinomas, making it promising target for cancer vaccines. Our group previously demonstrated C3 (OPSS)-liposomes enhance antigen uptake by antigen-presenting cells (APCs) via the complement pathway and, when combined with toll-like receptor (TLR) agonists, reduce tumor growth murine models. Methods: In present study, we evaluate immunogenicity of MUC1 peptide vaccines encapsulated C3-liposomes,...
Activation of antigen presenting cells (APCs) is necessary for immune recognition and elimination cancer. Our lab has developed a liposome nanoparticle that binds to complement C3 proteins present in serum. These C3-liposomes are specifically internalised by APCs other myeloid cells, which express C3-binding receptors. Known stimulating compounds, toll-like receptor (TLR) agonists, were encapsulated within the C3-liposomes, including monophosphoryl lipid A (MPLA), R848, CpG 1826, specific...
Gastric cancer is an aggressive and heterogeneous malignancy that often varies in presentation disease among racial ethnic groups. The Alaska Native (AN) people have the highest incidence mortality rates of gastric North America. This study examines molecular markers solid tumor samples from eighty-five AN adenocarcinoma patients using next-generation sequencing, immunohistochemistry, situ hybridization analysis. a low mutation burden with fewer somatic gene mutations their tumors compared...
To evaluate recent trends in gastric cancer incidence, response to treatment, and overall survival among Alaska Native (AN) people.
Mucin-1 (MUC1) is a highly relevant antigen for cancer vaccination due to its overexpression and hypo-glycosylation in high percentage of carcinomas. To enhance the immune response MUC1, our group has developed C3-liposomes that encapsulate MUC1 along with immunostimulatory compounds direct delivery antigen-presenting cells (APCs). bind complement C3, which interacts C3-receptors on APCs, resulting liposomal uptake tumor antigens APCs manner mimics pathogenic uptake. In this study, Toll-like...
In the tumor microenvironment, cytokines, growth factors, and oncogenes mediate constitutive activation of signal transducer activator transcription 3 (STAT3) signaling pathway in both cancer cells infiltrating immune cells. STAT3 drives tumorigenic changes that allow for increased survival, proliferation, resistance to apoptosis. The modulation is more complicated conflicting. myeloid cell phenotype towards an suppressive state, which mediates T inhibition. On other hand, leads...
Abstract Utilizing a young women's breast cancer cohort from the University of Colorado Cancer Center, we show that women diagnosed as late five-ten years postpartum have worse prognosis than nulliparous or during pregnancy, and represent ∼50% all patients. We propose involution following pregnancy accounts for this poor prognosis. Characterization identifies tissue remodeling programs share similarities with microenvironments known to promote metastasis. Using SHG imaging, find fibrillar...
Abstract Gastric cancer in the Alaska Native (AN) people occurs at a 3-fold higher incidence and 4-fold mortality rate compared to Non-Hispanic Whites (NHW), representing one of largest disparities AN population. We aimed review gastric burden identify clinicopathological factors that are associated with outcomes. Patient information was collected from 132 patients diagnosed between 2006-2015 Medical Center. The Surveillance, Epidemiology End Result database 18 used collect comparison United...