A5101760960- Bone and Joint Diseases
- Cardiac electrophysiology and arrhythmias
- Bone Tissue Engineering Materials
- Ion channel regulation and function
- Neonatal Respiratory Health Research
- Parvovirus B19 Infection Studies
- Epigenetics and DNA Methylation
- Orthopaedic implants and arthroplasty
- Immune Response and Inflammation
- Hip disorders and treatments
- Sparse and Compressive Sensing Techniques
- Bone Metabolism and Diseases
- Lipid metabolism and disorders
- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Cardiomyopathy and Myosin Studies
- Dermatological and COVID-19 studies
- Pregnancy and preeclampsia studies
- Hematological disorders and diagnostics
- Immunotherapy and Immune Responses
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Osteoarthritis Treatment and Mechanisms
- Tissue Engineering and Regenerative Medicine
Peking University Shenzhen Hospital
2020-2025
Harbin Medical University
2013-2024
Fourth Affiliated Hospital of Harbin Medical University
2024
Shanghai Jiao Tong University
2011-2024
XinHua Hospital
2013-2024
Southwest Petroleum University
2024
Chengdu Military General Hospital
2024
Beijing Institute of Technology
2023
University of Hong Kong - Shenzhen Hospital
2021-2022
Chinese Academy of Sciences
2020
Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global biochemical profile and provide a novel metabolism-related target improve therapeutic regimen of nasopharyngeal carcinoma (NPC). We used metabolomics approach investigate EBV-modulated metabolic changes, found that exogenous overexpression EBV-encoded latent membrane protein 1 (LMP1) significantly increased glycolysis. The deregulation several glycolytic genes, including hexokinase 2 (HK2), determined be...
Stem cells have tremendous potential for treating various human diseases. Protocols been established to differentiate stem into specific lineages through the provision of signals in form growth factors, cytokines, or small molecules. Herein we investigate an alternative strategy directed differentiation embryonic (hESCs)--extracellular-matrix (ECM) mediated differentiation. Decellularized ECM and conditioned media from appropriate committed cell lines are used required phenotype. Applying...
Numerous studies have shown that there are multiple neural activities involved in the process of bone regeneration, and promoting osteogenesis by network reconstruction is an effective strategy for repairing defects.
Background Newborns display distinct immune responses that contribute to susceptibility infection and reduced vaccine responses. Toll-like receptor (TLR) agonists may serve as adjuvants, when given individually or in combination, but of neonatal leukocytes many TLR are diminished. TLR8 more effective than other activating human vitro, little is known about whether different distinctly activate leukocytes. We characterized the vitro immuno-stimulatory activities a novel benzazepine agonist,...
Non-traumatic osteonecrosis of the femoral head (NONFH) remains a common refractory disease with poorly understood pathogenesis. Macrophage M1/M2 imbalance and chronic inflammatory microenvironment have been suggested to be closely related osteonecrosis. Here we describe direct visual evidence for involvement dynamic changes in macrophages human NONFH. Osteonecrosis induces responses macrophage enrichment reparative area, number cells falls during progressive-to end-stage Multiplex...
Abstract Osteoporosis, characterized by low bone mass and high fracture risk, challenges orthopedic implant design. Conventional 3D‐printed Ti6Al4V scaffolds are mechanically robust but suffer from poor regeneration in osteoporotic patients due to stress shielding cellular senescence. In this study, a functionalized “Cell Climbing Frame” is developed, aiming adapt the mechanical microenvironment of osteoporosis, effectively recruit support adhesion growth autologous marrow mesenchymal stem...
Electrospun fibrous matrices, mimicking extracellular matrix (ECM) hierarchical structures, are potential scaffolds for wound healing. To design functional scaffolds, it is important to explore the interactions between scaffold topographic features and cellular responses, especially directional migration phenotypic changes, which critical aspects during Here, accelerated persistent of human dermal fibroblasts (HDFs) observed on fibers with aligned orientation. Furthermore, can induce...
The combination of osteogenesis and angiogenesis dual-delivery trace element-carrying bioactive scaffolds stem cells is a promising method for bone regeneration repair. Canonical Wnt HIF-1α signaling pathways are vital BMSCs’ osteogenic differentiation secretion factors, respectively. Simultaneously, lithium (Li) copper (Cu) can activate the canonical pathway, Moreover, emerging evidence has shown that HIF related to coupling angiogenesis. However, it still unclear whether lithium-...
Abstract Steroid‐induced osteoblast apoptosis is a crucial pathological process in steroid‐induced osteonecrosis of the femoral head (SONFH). Autophagy can resist and AMPK plays an important role autophagy regulation. Aucubin from small tree Eucommia ulmoides Oliv., which has long history use orthopaedics traumatology Asian medicine, promote bone formation, but whether it slow or prevent steroid‐osteoblast unclear. Therefore, we investigated pathogenesis SONFH how responds to aucubin under...
Carvedilol is the current β-blocker of choice for suppressing ventricular tachyarrhythmia (VT). However, carvedilol's benefits are dose-limited, attributable to its potent β-blocking activity that can lead bradycardia and hypotension. The clinically used carvedilol a racemic mixture S-carvedilol non-β-blocking R-carvedilol. We recently reported novel analogues effective in arrhythmogenic Ca(2+) waves stress-induced VT without causing bradycardia. Thus, R-carvedilol enantiomer may also...
Inter-regulation between components of the renin–angiotensin system is common, but little known about direct regulatory effects Ang-(1–7) on expression tissue ACE2 and Mas receptor. Eighteen male spontaneously hypertensive rats (SHR) 20 normotensive Wistar-Kyoto were randomly allocated to four groups 9–10 each received either 24µg/kg per hour in saline or alone (5ml/h) by infusion for 14 consecutive days. Tail-cuff systolic blood pressures recorded was measured using quantitative real-time...
Icariin (Ica), the main active component of Herba Epimedii, has been identified as an osteogenic and angiogenic phytomolecule. To develop a bioactive scaffold for enhancing bone repair, Ica was loaded into porous tricalcium phosphate (TCP) scaffolds, obtained Ica/TCP composites were investigated treating osteonecrosis femoral head (ONFH) in rabbit model. ONFH histopathologically confirmed at two weeks after methylprednisolone acetate injection, rabbits treated with scaffolds (group A), TCP...
Abstract Due to the uncertainty of trauma or infection, customized bone substitutes are often required in clinic. Meanwhile, excessive use antibiotics may lead drug resistance. Therefore, design anti-infection tissue engineering scaffold is very important. In this study, porous titanium alloy scaffolds were designed and fabricated by 3D printing. TiO 2 nanotubes further constructed on through electrochemical anodic oxidation, achieving loading functions. The micron-level bionic pores...
Abstract Objectives Bronchopulmonary dysplasia (BPD), the most common late morbidity in preterm infants, is characterized by impaired alveolar development caused persistent lung inflammation. Studies have shown that NOD‐, LRR‐ and pyrin domain‐containing 3 (NLRP3) inflammasome‐mediated inflammation critically involved of BPD. As a traditional Chinese medicinal herb, Eclipta prostrata (EAP) exhibits potent anti‐inflammatory properties. Our study aims to investigate whether EAP could improve...
The prognosis of high‑risk neuroblastoma remains poor. Clinical first‑line drugs for treating have been developed over the previous half‑century; however, progress in identification new with high efficiency is required. Bufalin, one major components extracts obtained from venom Chinese toad Bufo gargarizans, which used to treat heart failure Asian Pacific countries, has reported be a potential drug against multiple types tumor; detailed mechanisms underlying its antitumor activities remain...