L. Chen

ORCID: 0009-0005-5481-7678
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About
Contact & Profiles
Research Areas
  • Circadian rhythm and melatonin
  • Hydrogen Storage and Materials
  • Metal and Thin Film Mechanics
  • Aluminum Alloys Composites Properties
  • Fusion materials and technologies
  • Advanced materials and composites
  • Microstructure and mechanical properties
  • MXene and MAX Phase Materials
  • Magnesium Alloys: Properties and Applications
  • Anesthesia and Neurotoxicity Research
  • Boron and Carbon Nanomaterials Research
  • Superconducting Materials and Applications
  • COVID-19 Impact on Reproduction
  • Advanced Chemical Physics Studies
  • Corrosion Behavior and Inhibition
  • Fungal Infections and Studies
  • Cancer Risks and Factors
  • Gold and Silver Nanoparticles Synthesis and Applications
  • Music Technology and Sound Studies
  • Histone Deacetylase Inhibitors Research
  • Intermetallics and Advanced Alloy Properties
  • Antifungal resistance and susceptibility
  • Endometrial and Cervical Cancer Treatments
  • Superconductivity in MgB2 and Alloys
  • nanoparticles nucleation surface interactions

Xinjiang Agricultural University
2025

Xinjiang Institute of Water Resources and Hydropower Research
2025

Shanxi Datong University
2024

Xiangya Hospital Central South University
2024

Central South University
2014-2024

Nanchang Hangkong University
2015-2019

The University of Texas Southwestern Medical Center
2005

Our goal in this work was to illustrate the Epstein-Barr virus (EBV)-modulated global biochemical profile and provide a novel metabolism-related target improve therapeutic regimen of nasopharyngeal carcinoma (NPC). We used metabolomics approach investigate EBV-modulated metabolic changes, found that exogenous overexpression EBV-encoded latent membrane protein 1 (LMP1) significantly increased glycolysis. The deregulation several glycolytic genes, including hexokinase 2 (HK2), determined be...

10.1038/onc.2014.32 article EN cc-by Oncogene 2014-03-24

Circadian clock perturbation frequently occurs in cancer and facilitates tumor progression by regulating malignant growth shaping the immune microenvironment. Emerging evidence has indicated that genes are disrupted melanoma linked to escape. Herein, we found expression of retinoic acid receptor-related orphan receptor-α (RORA) is downregulated patients with higher RORA have a better prognosis after immunotherapy. Additionally, was significantly positively correlated T-cell infiltration...

10.1158/0008-5472.can-23-3942 article EN cc-by-nc-nd Cancer Research 2024-05-08

In order to find good candidate materials for degradable fracturing ball applications, the microstructure, mechanical behavior and corrosion properties of as‐cast Mg‐17Al‐3Zn‐xCu alloys were investigated using optical microscope, scanning electronic microscope equipped with energy dispersive spectroscope, compression tests, electrochemical measurements, immersion tests. The results show that Cu addition affects not only amount but also morphology distribution T‐phases. Al has a large...

10.1002/maco.201408090 article EN Materials and Corrosion 2015-02-16

Filters serve as core equipment to ensure the normal operation of micro-irrigation systems, with head loss and filtration efficiency serving two key indicators for evaluating performance. In this study, we used a pre-pump filter-pontoon mesh rotary filter research object conducted physical model tests under flow rate (798–1050 L1 h−1), sand content (0.5–2.5 g1 L−1), aperture screen (0.125–0.180 mm). We then adopted range analysis, variance analysis (ANOVA), dimensional multiple linear...

10.1038/s41598-025-87708-y article EN cc-by-nc-nd Scientific Reports 2025-02-04

10.1016/j.ijhydene.2016.05.165 article EN International Journal of Hydrogen Energy 2016-06-18

10.1016/j.ijhydene.2015.07.146 article EN International Journal of Hydrogen Energy 2015-08-19

To evaluate the therapeutic outcomes of weight loss and metformin use in patients with endometrial hyperplasia (EH), to identify factors influencing treatment efficacy.

10.2147/ijwh.s477045 article EN cc-by-nc International Journal of Women s Health 2024-11-01

The rise of "bedroom producers" has democratized music creation, while challenging producers to objectively evaluate their work. To address this, we present AI TrackMate, an LLM-based chatbot designed provide constructive feedback on productions. By combining LLMs' inherent musical knowledge with direct audio track analysis, TrackMate offers production-specific insights, distinguishing it from text-only approaches. Our framework integrates a Music Analysis Module, LLM-Readable Report, and...

10.48550/arxiv.2412.06617 preprint EN arXiv (Cornell University) 2024-12-09

<div>Abstract<p>Circadian clock perturbation frequently occurs in cancer and facilitates tumor progression by regulating malignant growth shaping the immune microenvironment. Emerging evidence has indicated that genes are disrupted melanoma linked to escape. Herein, we found expression of retinoic acid receptor–related orphan receptor-α (RORA) is downregulated patients with higher RORA have a better prognosis after immunotherapy. Additionally, was significantly positively...

10.1158/0008-5472.c.7348784 preprint EN 2024-07-15

<div>Abstract<p>Circadian clock perturbation frequently occurs in cancer and facilitates tumor progression by regulating malignant growth shaping the immune microenvironment. Emerging evidence has indicated that genes are disrupted melanoma linked to escape. Herein, we found expression of retinoic acid receptor–related orphan receptor-α (RORA) is downregulated patients with higher RORA have a better prognosis after immunotherapy. Additionally, was significantly positively...

10.1158/0008-5472.c.7348784.v1 preprint EN 2024-07-15
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