A5013515757- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- Periodontal Regeneration and Treatments
- Extracellular vesicles in disease
- Tissue Engineering and Regenerative Medicine
- Orthopaedic implants and arthroplasty
- Cellular Mechanics and Interactions
- Dental Implant Techniques and Outcomes
- MicroRNA in disease regulation
- Wound Healing and Treatments
- Sarcoma Diagnosis and Treatment
- Mesenchymal stem cell research
- Circular RNAs in diseases
- Electrospun Nanofibers in Biomedical Applications
- Anatomy and Medical Technology
- Osteoarthritis Treatment and Mechanisms
- Proteoglycans and glycosaminoglycans research
- Supramolecular Self-Assembly in Materials
- RNA Interference and Gene Delivery
- Orthopedic Infections and Treatments
- Medical Imaging and Analysis
- Additive Manufacturing and 3D Printing Technologies
Sichuan University
2022-2025
The delayed healing of diabetic wounds is directly affected by the disturbance wound microenvironment, resulting from persistent inflammation, insufficient angiogenesis, and impaired cell functions. Mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) showed considerable therapeutic potential in healing. However, low retention rate MSC-EVs at sites hampers their efficacy. For skin exposed to outer environment, using a hydrogel with tissue adhesiveness under moist condition...
Extracellular vesicles (EVs) are biologically active nanoparticles secreted by cells, which have a variety of physiological functions, such as promoting cell proliferation, regulating immunity, anti-inflammation, and facilitating angiogenesis. However, the application EVs is limited defects low therapeutic efficiency, lack targeting, unstable effects. In recent years, various engineering methods been developed to enhance function EVs. addition, research on isolation mechanisms has also made...
Abstract Osteoporosis, characterized by low bone mass and high fracture risk, challenges orthopedic implant design. Conventional 3D‐printed Ti6Al4V scaffolds are mechanically robust but suffer from poor regeneration in osteoporotic patients due to stress shielding cellular senescence. In this study, a functionalized “Cell Climbing Frame” is developed, aiming adapt the mechanical microenvironment of osteoporosis, effectively recruit support adhesion growth autologous marrow mesenchymal stem...
Natural products rich in phytoestrogens, particularly those derived from traditional Chinese medicine (TCM) herb, have garnered increased attention. Plants-derived extracellular vesicles are emerging as a promising strategy cell communication...
Alveolar bone defects are often irregular in shape and can severely affect patients' physical psychological well-being, posing significant challenges treatment, particularly cases complicated by systemic diseases. This study presents a shape-adaptive hydrogel with sequential antibacterial osteogenic functions designed to repair associated osteoporosis. Naringin, an estrogen analogue, was conjugated the
Avascular necrosis of the femoral head is a common hip joint disease. Due to damage and destruction blood supply head, ischemic bone cells marrow leads structural changes collapse head. In this study, medicine device integrated designed porous Ti6Al4V reconstruction rod (referred as rod) was prepared by 3D printing technology. The mechanical validity verified finite element analysis. Through infilling mercapto hyaluronic acid hydrogel containing icariin into structure, construction achieved....
Nano-scale morphology on bone tissue engineering scaffold plays an essential role in cell behavior regulation and regeneration. In this study, patient-customized porous scaffolds were fabricated by 3D printing. Then functionalized nanorod morphologies controllably fabricated. The influence of nanorods geometrical cues cellular behaviors the mechanics triggered osteogenesis studied. vitro studies indicated that with a diameter 30 nm accelerated proliferation osteogenic differentiation....