A5102941175- Allergic Rhinitis and Sensitization
- Dermatology and Skin Diseases
- Skin and Cellular Biology Research
- Asthma and respiratory diseases
- MicroRNA in disease regulation
- RNA modifications and cancer
- RNA regulation and disease
- Cancer-related molecular mechanisms research
- Connexins and lens biology
- Ferroptosis and cancer prognosis
- RNA Research and Splicing
- Genetic and rare skin diseases.
- Cytokine Signaling Pathways and Interactions
- Ion Channels and Receptors
- Inflammasome and immune disorders
- Food Allergy and Anaphylaxis Research
- melanin and skin pigmentation
- Psoriasis: Treatment and Pathogenesis
- Membrane Separation and Gas Transport
- Skin Diseases and Diabetes
- Microbial Metabolism and Applications
- Endoplasmic Reticulum Stress and Disease
- Hearing, Cochlea, Tinnitus, Genetics
- Carbon Dioxide Capture Technologies
- Pancreatitis Pathology and Treatment
Peking University Shenzhen Hospital
2016-2025
University of Hong Kong - Shenzhen Hospital
2025
Tianjin Medical University General Hospital
2021-2025
Hong Kong University of Science and Technology
2022-2024
University of Hong Kong
2022-2024
Nankai University
2023
Tianjin Medical University
2021
Peking University
2015-2020
Peking University First Hospital
2018-2020
Shantou University
2015-2016
Abstract Psoriasis is an autoinflammatory skin disease characterized by the abnormal activation of epidermal keratinocytes. The Hippo-YAP pathway evolutionarily conserved that plays important roles in organ size control and tumorigenesis. Recently, accumulating evidence demonstrated YAP1, core downstream component pathway, was up-regulated psoriasis patients, suggesting its possible role development. However, precise function mechanism pathogenesis are still not well-clarified. In present...
Abstract Psoriasis is an auto-inflammatory skin disease characterized by abnormal activation of epidermal keratinocytes, aberrant neovascularization, and dysregulation immune cells. MicroRNAs are small non-coding RNAs that mainly function in the post-transcriptional regulation gene expression. Recently, accumulating evidence has demonstrated expression microRNAs dysregulated psoriasis patients play key roles pathogenesis. Downregulation miR-193b-3p been identified to be associated with...
Background Filaggrin gene (FLG) plays an important role in skin barrier function, and loss‐of‐function mutations of FLG have been shown to be a predisposing factor for atopic dermatitis (AD). The c.3321delA mutation is the most common Chinese population. We aim develop rapid, cost‐efficiency, reliable closed‐tube method that has not described detection mutation. Methods Recombinant wild‐type mutant plasmids were constructed, heterozygous prepared by mixing at 1:1 ratio. High‐resolution...
Autoimmune hepatitis (AIH) is an immune-mediated chronic inflammatory liver disease, and its pathogenesis not fully understood. Our previous study discovered that receptor interacting protein kinase 3 (RIP3) correlated with serum transaminase levels in AIH patients. However, role underlying mechanism are poorly Here, we detected the increased expression activation of RIP3 livers patients animal models AIH. The inhibition by GSK872 prevented concanavalin A (ConA)-induced (IMH) reduced hepatic...
Epidermal barrier dysfunction is the initial event in development of atopic dermatitis (AD). Recent studies have identified a crucial role for aryl hydrocarbon receptor (AHR) controlling gene expression filaggrin and other skin proteins, suggesting an underlying association between AHR AD pathogenesis. To investigate polymorphisms susceptibility to AD‐associated phenotypes. We enrolled 487 patients with AD, 210 psoriasis 226 healthy controls (HCs) from Han Chinese population, genotyped two...
INTRODUCTION Atopic dermatitis (AD) is a common chronic inflammatory skin disorder that characterized by dry and disturbed barrier functions. Mutations in the filaggrin (FLG) gene, gene coding profilaggrin/filaggrin, have great impact on epidermal function are an important predisposing factor for AD. However, both Europeans Asians, presence of FLG mutations has been reported to be population-specific. mutation c.3321delA Asian-specific most Chinese population, accounting up 15% patients with...
Prurigo nodularis (PN), as a subtype of chronic prurigo (CPG), is characterized by nodular lesions and severe pruritus, which significantly affect patients' quality life.[1] It has been observed that patients with PN often have comorbidities, including physical mental diseases.[2] However, information on comorbidities in Chinese lacking. This study aims to fill this gap using representative patient population provide comprehensive data PN. based the China Type II Inflammatory Skin Disease...
Abstract Pachyonychia congenita (PC) is a rare genodermatosis showing heterogeneity with five causative keratin genes ( KRT6A, KRT6B, KRT6C, KRT16, or KRT17 ). Clinically, PC characterized by hypertrophic onychodystrophy, painful palmoplantar keratoderma, oral leukokeratosis, and follicular hyperkeratosis. We describe an atypical case of in young Chinese girl presenting generalized bullae identified recurrent heterozygous missense mutation c.1406T > C (p.Leu469Pro) KRT6A . This suggests...
DNA methylation is an important epigenetic modification that causes heritable changes in gene expressions without alterations sequences. It has been reported aberrant may play role the development of allergic reactions, but it unclear how patterns their biological roles these diseases. This article reviews regulation mechanisms occurrence common reactions or diseases, such as atopic dermatitis, contact urticaria and food allergy, which help to better understand genetic regulatory...