A5101711830- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Systemic Lupus Erythematosus Research
- Liver Disease and Transplantation
- Drug Transport and Resistance Mechanisms
- Cancer, Hypoxia, and Metabolism
- Thyroid Cancer Diagnosis and Treatment
- interferon and immune responses
- Radiomics and Machine Learning in Medical Imaging
- Pediatric Hepatobiliary Diseases and Treatments
- Central Venous Catheters and Hemodialysis
- RNA modifications and cancer
- Organ Transplantation Techniques and Outcomes
- Gastric Cancer Management and Outcomes
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Medical Research and Treatments
- Platelet Disorders and Treatments
- Cancer, Lipids, and Metabolism
- Head and Neck Anomalies
- Epigenetics and DNA Methylation
- Cytomegalovirus and herpesvirus research
- Cerebrovascular and Carotid Artery Diseases
- Neuroendocrine Tumor Research Advances
- Hepatitis C virus research
Beijing University of Chinese Medicine
2025
Tianjin Medical University General Hospital
2016-2025
Shanghai Innovative Research Center of Traditional Chinese Medicine
2024
Zhongshan Hospital
2024
Jiangsu Province Hospital
2022-2024
Chinese PLA General Hospital
2010-2024
Shaanxi Normal University
2023-2024
Ruijin Hospital
2022-2024
Shanghai Jiao Tong University
2024
Fudan University
2017-2024
Abstract Tobramycin inhalation solution is used to treat chronic Pseudomonas aeruginosa lung infection in cystic fibrosis (CF) patients. We evaluated the efficacy and safety of a novel, light‐porous particle, dry‐powder formulation tobramycin, which was developed improve delivery efficiency airways substantially reduce time. In this randomized, double‐blind study, patients with CF (age 6–21 years) received tobramycin powder (112 mg tobramycin) twice daily (n = 46) or placebo 49) via T‐326...
To better understand the antibiotic resistance, virulence genes, and some related drug-resistance genes of
Objective. To determine the features predictive of atherosclerotic cardiovascular damage in patients with SLE. Methods. SLE LUMINA (LUpus MInorities: NAture vs nurture) (n = 637), aged ⩾16 years, disease duration ⩽5 years at baseline (T0), African–American, Hispanic and Caucasian ethnicity were studied. Atherosclerotic was defined by following items SLICC Damage Index (SDI) domain: angina or coronary artery pass surgery, myocardial infarction and/or congestive heart failure; factors...
Tropifexor (LJN452) is a potent, orally available, non-bile acid farnesoid X receptor agonist under clinical development for chronic liver diseases. Here, we present results from first-in-human study of tropifexor following single- and multiple-ascending doses (SAD/MAD) food effect substudy in healthy volunteers. The SAD included 6 fasted cohorts receiving 10- to 3000-µg or placebo 1 cohort 300-µg with high-fat meal. MAD 4 lean 10 100 µg obese 30-µg once-daily 14 days. Pharmacodynamic...
Background Patients with chronic obstructive pulmonary disease (COPD) commonly suffer from acute exacerbations (AECOPD) and display varying severity. However, there is no available biomarker for the classification of AECOPD. This study aimed at investigating sputum cellular profiles to classify patients Methods A total 83 AECOPD 26 healthy controls were recruited. Their demographic clinical characteristics recorded, their lung function was examined. The phenotypes inflammatory cells...
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths worldwide. As a branch glucose metabolism, hexosamine biosynthesis pathway (HBP) has been reported to play critical role in insulin resistance and progression cancer. Glutamine:fructose-6-phosphate amidotransferase (GFAT) rate-limiting enzyme HBP; nevertheless, prognostic value GFAT1 HCC remains elusive. In this study, we found that high expression was significantly associated with serum alpha-fetoprotein...
Patients with prolonged inflammatory bowel disease (IBD) can develop into colorectal cancer (CRC), also called colitis-associated (CAC). Studies have shown the association between gut dysbiosis, abnormal bile acid metabolism, and inflammation process. Here, we aimed to investigate these two factors in CAC model. C57BL/6 mice were randomly allocated groups: azoxymethane/dextran sodium sulfate (AOM/DSS) control. The AOM/DSS group received AOM injection followed by DSS drinking water....
Abstract PKM2 mediates the Warburg effects and is crucial for tumorigenesis, but its role in hyperplastic skin disorders remains elusive. In this study, we investigated function of psoriatic keratinocytes. We found that expression nuclear translocation were induced epidermis psoriasis patients, contributing to aerobic glycolysis cell growth. Moreover, mass spectrometry combined with immunoprecipitation analysis revealed could interact TRIM33, an E3 ubiquitin ligase nucleus, interaction...
Autoimmune hepatitis (AIH) is a progressive liver disease mediated by the immune system that involves an imbalance in pro-inflammatory and regulatory mechanisms including T cells (Tregs), helper 17 (Th17) cells, Th1, macrophages, many other cells. Current steroid therapy for AIH has significant systemic side effects poorly tolerated some individuals. Therefore, there urgent need alternative treatments. Maintaining homeostasis macrophage differentiation activation crucial regulating responses...
4′,5,6,7-tetrahydoxyisoflavone (6-hydroxygenistein, 6-OHG) is a hydroxylated derivative of genistein with excellent antioxidant activity, but whether 6-OHG can protect hypoxia-induced damage unclear. The objective current study was to evaluate the protective effect and underling mechanism against injury via network pharmacology cellular experiments. 6-OHG-related hypoxia injury-related targets were screened by public databases. intersected used for constructing PPI performing GO KEGG...
Abstract Paeoniflorin is a natural pharmaceutical ingredient with widely biological activity. However, as hydrophilic drug, the problem of low transdermal rate limits its clinical application. To overcome this shortage, LUVs were used biocompatible carriers paeoniflorin in study. We prepared paeoniflorin-loaded large unilamellar vesicles (LUVs) W/O/W structure by microfluidics. four kinds chips to prepare and explored effects chip structures on properties applying both experiments numerical...
People with genetic or acquired defects in the biosynthesis of bile acids may suffer from cholestasis. Patients a deficiency 3β‐hydroxy‐Δ 5 ‐C 27 ‐steroid dehydrogenase/isomerase form 3β,7α‐dihydroxy‐and 3β,7α,12α‐trihydroxy‐5‐cholenoic acids, sulfated and partially glycine‐conjugated forms which are found their urine bile. 3‐Oxo‐Δ 4 detected patients 5β‐reductase. It has been postulated that these unusual might act as cholestatic agents patients. The aim present study was to test this...
Objective To examine the patterns of methotrexate (MTX) use among rheumatoid arthritis (RA) patients. Methods Using data from RA patients enrolled in a US commercial health plan and Medicare program, we identified initiating oral MTX. Persistence with MTX (oral or subcutaneous [SC]) was defined as no gap for ≥90 days. Results New users (n = 20,431) were 76.9% women, had mean ± SD age 69.7 11.7 years, contributed median followup 2.6 years (interquartile range 1.7–3.5 years). Only 38% received...