A5100439455- CAR-T cell therapy research
- Pancreatic function and diabetes
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Gastric Cancer Management and Outcomes
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
- Diabetes and associated disorders
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Cancer Research and Treatments
- Circular RNAs in diseases
- Esophageal Cancer Research and Treatment
- Spinal Fractures and Fixation Techniques
- Cancer-related Molecular Pathways
- Meningioma and schwannoma management
- Pancreatic and Hepatic Oncology Research
- Spinal Dysraphism and Malformations
- Ultrasound and Hyperthermia Applications
- Nanoparticle-Based Drug Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Immune cells in cancer
- Dental materials and restorations
- Hemodynamic Monitoring and Therapy
- Adipokines, Inflammation, and Metabolic Diseases
Fujian Medical University
2019-2025
Union Hospital
2025
Ocean University of China
2024-2025
Kunming University of Science and Technology
2013-2024
Sichuan University
2014-2024
Qilu Hospital of Shandong University
2008-2024
Xiamen University
2011-2024
Southwest Jiaotong University
2024
Chengdu Third People's Hospital
2024
Qingdao National Laboratory for Marine Science and Technology
2024
Chronic low-grade inflammation has long been recognized as the central link between obesity and type 2 diabetes (T2D). The novel subset of T helper (Th) cells, Th22, plays an emerging role in chronic inflammation. We investigated potential association Th22 pathogenesis T2D.Ninety T2D inpatients (T2D group), 30 healthy participants with BMI ranged from 19 to 23.9 kg/m2 (CTL group) metabolically obese controls ≥ (MHO were employed our study. Peripheral frequencies Th1 Th17 cells determined by...
Early diagnosis of pancreatic ductal adenocarcinoma (PDAC) is challenging because its depth, which often leads to misdiagnosis during ultrasound examinations. The unique PDAC tumor microenvironment (TME) characterized by significant fibrous tissue growth, and high interstitial pressure hinders drug penetration into tumors. Additionally, hypoxia immune suppression within the contribute poor responses radiotherapy chemotherapy, ultimately leading an unfavorable prognosis. In this study,...
The root powder of long-root Eichhornia crassipes, as a new kind biodegradable adsorbent, has been tested for aqueous adsorption Pb, Zn, Cu, and Cd. From FT-IR, we found that the absorption peaks phosphorous compounds, carbonyl, nitrogenous compounds displayed obvious changes before after which illustrated plant characteristics may play role in binding with metals. Surface properties morphology powders have characterized by means SEM BET. Energy spectrum analysis showed metals were adsorbed...
Anatomic data regarding femoral version, neck-shaft angle, and acetabular anteversion are still limited in Chinese Han adult population. The aim of this study was to investigate the effects age, sex, body laterality on 3 important anatomic indicators healthy adults. Measurements were performed independently by experienced observers using picture archiving communication system (PACS) adults who had received imaging tests femur acetabulum between January 2009 October 2014. Relevant measured...
Analysis using publicly available algorithms has found that high mobility group AT-hook 2 (HMGA2), a key transcriptional regulatory factor, is potential target of microRNA-204 (miR-204). Some studies have shown both miR-204 and HMGA2 are associated with cancer development.We examined the possible relationship between in development thyroid cancer.We assessed expression specimens cell lines real-time polymerase chain reaction (PCR). Luciferase reporter assay was used to confirm associations....
Video-assisted thoracoscopic surgery (VATS) has been increasingly used in the management of thymic epithelial tumours. However, its oncological efficacy remains to be proved. The purpose this study is compare outcomes following versus open case-matched groups patients with early-stage tumours from Chinese Alliance for Research Thymomas (ChART) retrospective database. Between 1994 and 2012, a total 1087 who underwent UICC (Union International Cancer Control) pathological Stage I ChART...
Human Vγ9Vδ2 T cells have attracted considerable attention as novel alternative antigen-presenting (APCs) with the potential to replace dendritic in antitumor immunotherapy owing their high proliferative capacity and low cost. However, utility of γδ APCs induce CD8+ cell-mediated immune response, well mechanism by which they perform APC functions, remains unexplored. In this study, we found that activated were capable inducing robust cell responses osteosarcoma cells. Activated also...
Objective C-peptide has been reported to be a marker of subclinical atherosclerosis in type 2 diabetes mellitus (T2DM) patients, whereas its role coronary artery disease (CAD) not clarified, especially diabetics with differing body mass indices (BMIs). Design and Methods This cross-sectional study included 501 patients T2DM. First, all subjects were divided into the following two groups: CAD non-CAD. Then, binary logistic regression was used determine risk factors for patients. To clarify...
miR-362 is a recently discovered member of the microRNA family, and it modulates variety physical activities plays an important role in occurrence development many tumors. However, biological functions hsa-miR-362-5p non-small-cell lung carcinoma (NSCLC) are unknown. Transwell assay colony formation were used to determine migration, invasion, proliferation NSCLC cells vitro. A subcutaneous tumor model nude mice was established detect growth vivo. The direct binding 3'UTR Semaphorin 3A...
The identification of drug-target interaction (DTI) is crucial for drug discovery. However, how to reduce the graph neural network's false positives due its bias and negative transfer in original bipartite remains be clarified. Considering that impact heterogeneous auxiliary information on DTI varies depending target, we established an adaptive enhanced personalized meta-knowledge network named
Diabetes mellitus is a metabolic disorder characterized by elevated blood sugar and progressive failure of insulin-producing beta-cells. Persistent hyperglycemia fluctuation are two general phenomena in diabetic patients, both them can result an increased frequency beta-cell apoptosis. Therefore, rescuing pancreatic beta-cells from glucotoxicity-induced apoptosis increasing viewed as promising means for curing. The aim this study was to investigate whether adiponectin, important cytokine...
Background The definition of deep tissue injury was derived from multiple clinical cases as "A purple or maroon localized area discolored intact skin blood-filled blister due to damage underlying soft pressure and/or shear". Acidic fibroblast growth factor (aFGF) significantly improves wound healing under diabetic conditions. However, date, the therapeutic application aFGF has been limited, its low delivery efficiency and short half-life. Methodology/Principal Findings Using an animal model...
To explore the effects of different lifestyle choices on mild cognitive impairment (MCI) and to establish a decision tree model analyse their predictive significance incidence MCI.Study participants were recruited from geriatric physical examination centres October 2015 2019: 330 MCI patients 295 normal (NC) patients. Cognitive function was evaluated by Mini-Mental State Examination Scale (MMSE) Clinical Dementia (CDR), while Barthel Index (BI) used evaluate life ability. Statistical...