A5100461801- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Circular RNAs in diseases
- Kruppel-like factors research
- Gastric Cancer Management and Outcomes
- Lung Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Respiratory Support and Mechanisms
- Sarcoma Diagnosis and Treatment
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Peptidase Inhibition and Analysis
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Breast Cancer Treatment Studies
- Digital Radiography and Breast Imaging
- Medical Imaging and Pathology Studies
- Protease and Inhibitor Mechanisms
- Breast Lesions and Carcinomas
- Cancer, Hypoxia, and Metabolism
Zhongnan Hospital of Wuhan University
2020-2024
Wuhan University
2020-2024
Jiangsu University
2021-2024
Inner Mongolia Maternal and Child Health
2024
Affiliated Hospital of Jiangsu University
2021-2024
Hebei Medical University
2024
Affiliated Hospital of Nantong University
2014-2023
Nantong University
2014-2023
North Minzu University
2023
Hefei University of Technology
2023
Abstract Acute lung injury (ALI) is a complex disease with numerous causes. This review begins discussion of development from direct or indirect pulmonary insults, as well varied pathogenesis. The heterogeneous nature ALI then elaborated upon, including its epidemiology, clinical manifestations, potential biomarkers, and genetic contributions. Although no medication currently approved for this devastating illness, supportive care pharmacological intervention treatment are summarized,...
Recently, several molecular subtypes with different prognosis have been found in lung adenocarcinoma (LUAD). However, the characteristics of ferroptosis and associated tumor microenvironment (TME) cell infiltration not fully studied LUAD. Using 1160 samples, we explored mediated by ferroptosis-related genes, along TME infiltration. The score was constructed using least absolute shrinkage selection operator regression (LASSO) method to quantify a single tumor. Three related ferroptosis,...
Renal ischemia-reperfusion (IR) is frequently observed in patients who are critically ill, yet there no reliable or effective approaches for the treatment of this condition. Ferroptosis, a form programmed cell death, regulated by key genes such as glutathione peroxidase 4 (GPX4) and heme oxygenase-1 (HMOX1) participates injury renal tubular epithelial cells during IR. This study aimed to investigate miRNA-mRNA regulatory networks involved ferroptosis following Using bioinformatics analysis,...
Abstract Overexpression of the pro‐survival protein heme oxygenase‐1 (HO‐1) and loss pro‐apoptotic tumour suppressor PTEN are common events in prostate cancer (PCA). We assessed occurrence both HO‐1 expression deletion two cohorts men with localized castration‐resistant (CRPC). The phenotypic cooperation these markers was examined preclinical clinical models. Overall, there a statistically significant difference epithelial between benign, high‐grade prostatic intraepithelial neoplasia...
Apigenin, a natural flavonoid has been reported against variety of cancer types. However, it is unclear whether apigenin can promote autophagy and ferroptosis in Ishikawa cells. There are few reports on the mechanism endometrial We found that iron accumulation, lipid peroxidation, glutathione consumption, p62, HMOX1, ferritin were increased, while, solute carrier family 7 member 11 peroxidase 4 decreased. Ferrostatin-1, an iron-death inhibitor could reverse effects On other hand, via...
Abstract Background Due to individual differences in tumors and immune systems, the response rate immunotherapy is low lung adenocarcinoma (LUAD) patients. Combinations with other therapeutic strategies improve efficacy of LUAD Although radioimmunotherapy has been demonstrated effectively suppress tumors, underlying mechanisms still need be investigated. Methods Total RNA from cells was sequenced before after radiotherapy identify differentially expressed radiation-associated genes. The...
Aims: To investigate the impact of 2005 International Society Urological Pathology (ISUP) Gleason grading consensus in contemporary practice. Methods and results: The scores (GS) were compared two consecutive patient cohorts with matched biopsies prostatectomies: (i) 908 patients evaluated before ISUP (July 2000–June 2004) (ii) 423 after (October 2005–June 2007). All prostatectomies performed scored one institution sampled processed identically. There was a higher percentage biopsy...
Abstract Background TUBA1C is a microtubule component that involved in variety of cancers. Our main objective was to investigate expression, its prognostic value, potential biological functions, and impact on the immune system patients with lung adenocarcinoma (LUAD). Methods The Cancer Genome Atlas (TCGA), Gene Expression Profiling Interactive Analysis (GEPIA) Immunohistochemistry were used analyze clinicopathology, overall survival (OS), disease-free (DFS) LUAD patients. We also determined...
Amid the coronavirus disease 2019 (COVID-19) pandemic, we analyzed clinical characteristics of acute lung injury (ALI) in COVID-19 patients and reported their similarity dissimilarity to those non-COVID-19 intensive care unit (ICU).
In plants, recent studies have revealed that N6-methyladenosine (m6A) methylation of mRNA has potential regulatory functions this modification in many biological processes. m6A methyltransferase, demethylase and m6A-binding proteins can cause differential phenotypes, indicating may critical roles the plant. study, we depicted map sea buckthorn (Hippophae rhamnoides Linn.) transcriptome. Similar to A. thaliana, sites transcriptome is significantly enriched around stop codon within...
NF45 (also known as ILF2), one subunit of NF-AT (nuclear factor activated T cells), repairs DNA breaks, inhibits viral replication, and also functions a negative regulator in the microRNA processing pathway combination with NF90. Recently, it was found that implicated mitotic control HeLa cells deletion endogenous decreases growth cells. While role cancer biology remains under debate. In this study, we analyzed expression clinical significance esophageal squamous cell carcinoma ESCC. The...
Pulmonary enteric adenocarcinoma (PEAC), a rare type of non-small cell lung cancer, has similar histological and immunohistochemical morphology to colorectal adenocarcinoma. Cadherin-17 (CDH17) SATB homeobox 2 (SATB2) immunoexpression have recently been demonstrated in In this study, we evaluated the value CDH17 SATB2 diagnosis pulmonary metastatic adenocarcinoma.A total 13 PEAC cases 27 were enrolled our cohort study. We analyzed expressions CK7, CK20, CDX-2, villin, cadherin-17 (CDH17),...
BRCA1-associated protein-1 (BAP1) is an important nuclear-localized deubiquitinating enzyme that serves as a tumor suppressor in lung cancer; however, its function and regulation are largely unknown. In this study, we found BAP1 protein levels were dramatically diminished cancer tissues while mRNA did not differ significantly, suggesting post-transcriptional mechanism was involved regulation. Because microRNAs (miRNAs) powerful regulators of gene expression, used bioinformatic analyses to...
Real-time consultation between referring physicians or radiologists with an expert is critical for timely and adequate management of problem cases. During consultation, both sides need to: 1) synchronously manipulate high-resolution digital radiographic images large volume MR/CT images; 2) perform interpretation interactively; 3) converse audio. We present a specifically designed teleconsultation system in imaging communication medicine picture archiving systems clinical environment. The...
Significance of tertiary Gleason pattern/grade 5 on prostatectomy has been studied, but its significance biopsy remains uncertain. Recent International Society Urological Pathology consensus conference recommended that score is generated by adding grade to the primary grade. We examined preoperative clinical and findings in 53 patients with pattern 119 primary/secondary 5. Prostatectomy prostate-specific antigen (PSA) failure rates were compared surgically treated patients. Cause-specific...
Abstract The classification of the distinct group mesenchymal neoplasms, first described as ‘Xp11 translocation perivascular epithelioid cell tumor (PEComa)’ and for which term ‘melanotic Xp11 neoplasm’ or neoplasm with melanocytic differentiation’ has recently been proposed, remains challenging controversial. We collected 27 melanotic largest series to date, a comprehensive evaluation. Fourteen cases, together eight alveolar soft part sarcomas (ASPS), nine conventional PEComas control seven...
Abstract Background Lung adenocarcinoma (LUAD) is the leading cause of cancer-related death. This study aimed to develop and validate reliable prognostic biomarkers signature. Methods Differentially expressed genes were identified based on three Gene Expression Omnibus (GEO) datasets. Based 1052 samples’ data from our cohort, GEO The Cancer Genome Atlas, we explored relationship clinicopathological features NEIL3 expression determine clinical effect in LUAD. Western blotting (22 pairs tumor...
Background and purpose The association between the presence of cerebral microbleeds (CMBs) serum vascular endothelial growth factor (VEGF) levels in patients with Alzheimer's disease (AD) was investigated. Methods Consecutive AD who underwent magnetic resonance examination susceptibility‐weighted imaging (SWI) were prospectively examined. CMBs on SWI independently interpreted. number location assessed. Demographics including age, sex risk factors obtained. Serum VEGF measured an...
Lung adenocarcinoma (LUAD) is still one of the primary malignant diseases leading to higher mortality worldwide. It has been previously reported that multiple genes in CENPA-nucleosome associated complex (NAC) lung cancer can be used as prognostic markers; however, there lack comprehensive research on CENPA-NAC complex.The hub were obtained by analyzing gene expression omnibus (GEO) datasets. The key evolution LUAD identified according data from Cancer Genome Atlas (TCGA) database, and...