A5081915625- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Analysis
- Ginseng Biological Effects and Applications
- Natural product bioactivities and synthesis
- Chromatography in Natural Products
- Advancements in Transdermal Drug Delivery
- Drug Transport and Resistance Mechanisms
- Biochemical Analysis and Sensing Techniques
- Barrier Structure and Function Studies
- Food Quality and Safety Studies
- Metabolomics and Mass Spectrometry Studies
- Plant-based Medicinal Research
- Phytoestrogen effects and research
- Acute Ischemic Stroke Management
- Inhalation and Respiratory Drug Delivery
- Drug Solubulity and Delivery Systems
- Flavonoids in Medical Research
- Inflammatory mediators and NSAID effects
- Microfluidic and Capillary Electrophoresis Applications
- Medicinal Plant Pharmacodynamics Research
- Venous Thromboembolism Diagnosis and Management
- Acupuncture Treatment Research Studies
- Cancer-related gene regulation
- Microbial Natural Products and Biosynthesis
- Biological and pharmacological studies of plants
Beijing University of Chinese Medicine
2015-2025
Jishan County People's Hospital
2023
Purpose Maytansine (DM1) is a potent anticancer drug and limited in clinical application due to its poor water solubility toxic side effects. Zein widely used nano delivery systems good biocompatibility. In this study, we prepared DM1-loaded zein nanoparticles (ZNPs) achieve tumor targeting reduce effects of DM1. Methods: ZNPs were by phase separation Box-Behnken design was optimize the formulation. Then, confocal fluorescence microscope flow cytometry determine cellular uptake ZNPs. A549...
Abstract Paeoniflorin is a natural pharmaceutical ingredient with widely biological activity. However, as hydrophilic drug, the problem of low transdermal rate limits its clinical application. To overcome this shortage, LUVs were used biocompatible carriers paeoniflorin in study. We prepared paeoniflorin-loaded large unilamellar vesicles (LUVs) W/O/W structure by microfluidics. four kinds chips to prepare and explored effects chip structures on properties applying both experiments numerical...
Acute myeloid leukemia (AML) is a frequent and highly lethal hematological malignancy that difficult to treat. The research aimed clarify the molecular mechanisms of MIR-379-5p in AML progression. RT-qPCR was utilized evaluate expression levels patients control group. A ROC curve created assess clinical predictive value AML, while cell experiments used CCK-8 assay, flow cytometry, Transwell chambers. Predicted potential target genes by employing online bioinformatics tools, followed...
Geniposide is widely used in the treatment of cerebral ischemic stroke and cerebrovascular diseases for its anti-thrombotic anti-inflammatory effects. Recent studies demonstrated that geniposide could be absorbed promptly thoroughly by intranasal administration mice basically transported into brain. Here, we explored transport mechanism effect borneol muscone on human nasal epithelial cell (HNEC) monolayer. The cytotoxicity geniposide, borneol, their combinations HNECs was evaluated MTT...
Puerarin transport across a Calu-3 cell monolayer – an in vitro model of nasal mucosa permeability and the influence paeoniflorin menthol Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Zhi-Hao Tian, Yang, Hui-Chao Wu, Zhen Wang School Chinese Materia Medica, Beijing University Medicine, Chaoyang District, Beijing, People's Republic China Abstract: Nasal administration is high-potential delivery system, particularly because it can provide pathway from nose to brain. The objective this research...
Abstract Objective Our objective of this research was (1) to investigate the transport characteristics puerarin through MDCK-MDR1 and MDCK cells (2) evaluate effects paeoniflorin menthol on so as (3) explore enhancement mechanism. Methods The cytotoxicity drugs evaluated by MTT assay, studies were performed in both directions. membrane fluidity fluorescence recovery after photobleaching, potential estimated accumulation DiBAC4(3) cells. Key findings Puerarin showed relatively poor absorption...
The combined use of Panax notoginseng saponins (PNS)-based drugs and aspirin (ASA) to combat vascular diseases has achieved good clinical results. In this study, the superior efficacy was observed
The external preparation of the Tibetan medicine formula, Baimai ointment (BMO), has great therapeutic effects on osteoarthritis (OA). However, its molecular mechanism remains almost elusive. Here, a comprehensive strategy combining network pharmacology and docking with pharmacological experiments was adopted to reveal BMO against OA.
Puerarin transport across rat nasal epithelial cells and the influence of compatibility with paeoniflorin menthol Lin Zhang, Shou-Ying Du, Yang Lu, Chang Liu, Hui-Chao Wu, Zhi-Hao Tian, Min Wang, School Chinese Materia Medica, Beijing University Medicine, Chaoyang District, Beijing, People's Republic China Abstract: Nose-to-brain can provide an excellent pathway for drugs central nervous system. Consequently, how to make full use this in practical applications has become a focus drug design....
In this study, the influence of puerarin, paeoniflorin, and menthol on structure barrier function tight junctions (TJs) in Madin–Darby canine kidney epithelial (MDCK) MDCK-multi-drug resistance 1 (MDR1) cells was evaluated to determine mechanisms by which drugs cross blood–brain (BBB). Cells were treated with followed immunohistochemical staining occludin, claudin-1, F-actin. The then observed using laser-scanning confocal microscopy. Average optical density (AOD) immunofluorescence images...
To establish a determination method for the contents of ammonium glycyrrhetate,nardosinone,and curcumin in transdermal receptor liquid Baimai Ointment,and investigate percutaneous permeability Ointment and effects two kinds penetration enhancers on absorption three components. The were determined by high pressure chromatography( HPLC). vertical modified Franz diffusion cell was used to perform experiment vitro with abdominal skin mice( treated untreated). preferably rule effect enhancer....
Similar to traditional Chinese medicine (TCM), Tibetan emphasizes the concepts of holism, balance, and etiology. With individual as nexus macro- micro-ecologies, multi-layered systemic etiologies, inform therapeutic pharmacologies for cultivating network effects induce healing response. approaches health through perspectives that frame balance achieved in internal world inextricably linked external world, vice versa, includes expressions mind consciousness. The refers broader context natural...
To develop a GC-FID method to determine borneol's concentration in mouse tissues, and investigate the tissue distribution after intravenous intranasal administrations of borneol.Mouse brains, hearts, livers, spleens, lungs kidneys were collected at 1, 3, 5, 10, 20, 30, 60, 90, 120 min administration borneol with dose 30.0 mg x kg(-1). The drug tissues was extracted ethyl acetate, detected by GC, octadecane as internal standard.The calibration curve showed good linear relationship. Extraction...
To study the characteristics of intestinal absorption icariin and epimedin C Xianlinggubao capsules, compare capsules prepared by different processes.Non everted gut sac method was applied to investigate influence sites concentration on C, which were determined HPLC.The rate constants in duodenum absolutely more than that jejunum ileum (P < 0.05). The less kept at same level when concentrations drug solution high, middle low level. Ka three levels 0.040, 0.058, 0.061 h(-1) , respectively,...
Baimai is a complex of structure and function with the characteristics wide distribution, structure, multi-dimensional functions. Baimai, consisting channels in brain, internal hidden connecting viscera, external linking limbs, governs sensory, motor, information transmission functions human. According to Tibetan medicine, via "Long"(Qi) which moves Baimai. "Long" rough, light, cold, tiny, hard, dynamic. The dysfunction manifested as numbness, swelling pain, stiffness,...
To obtain a formulation with high bioavailability through evaluation of the stability three types Xuesaitong capsules in stomachs and intestines rats. We compared Panax notoginsenoside R1 as well ginsenosides Rg1, Rb1, Re, Rd different formulations. Artificial stomach fluid (ASF) artificial intestinal (AIF) were prepared. Stability was examined for 4 h 24 intestines. Samples analyzed at times by high-performance liquid chromatography. Percent content NGR1, GRg1, GRb1, GRe, GRd calculated....
To study the characteristics of intestinal absorption psoralen and isopsoralen Xianlinggubao capsule, compare capsule prepared by different technologies.Non everted gut sac method was applied to investigate influence sites drug concentration on absorption, which were determined HPLC.Although rate constants in duodenum more than that jejunum ileum, there no significance difference between them. The kept at same level when concentrations solution middle low level, while constant high...