Wen Chen

ORCID: 0000-0003-2013-9176
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Research Areas
  • Fractional Differential Equations Solutions
  • Nanofluid Flow and Heat Transfer
  • Phytochemistry and Biological Activities
  • Iterative Methods for Nonlinear Equations
  • Food Quality and Safety Studies
  • Analytical Chemistry and Chromatography
  • Genomics, phytochemicals, and oxidative stress
  • Hemoglobinopathies and Related Disorders
  • Animal Nutrition and Physiology
  • Carcinogens and Genotoxicity Assessment
  • Chromatography in Natural Products
  • Biopolymer Synthesis and Applications
  • Microbial Metabolites in Food Biotechnology
  • Iron Metabolism and Disorders
  • Image and Signal Denoising Methods
  • Digestive system and related health
  • Ginseng Biological Effects and Applications
  • Peroxisome Proliferator-Activated Receptors
  • Medicinal Plant Pharmacodynamics Research
  • Rheology and Fluid Dynamics Studies
  • Phytoestrogen effects and research
  • Pharmacological Effects of Natural Compounds
  • Numerical methods in engineering
  • Erythrocyte Function and Pathophysiology
  • Synthesis and Characterization of Heterocyclic Compounds

Nanjing Medical University
2025

Henan Agricultural University
2006-2024

Hohai University
2009-2022

Beijing Union University
2007-2022

Changsha Medical University
2019

State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering
2018

Nanjing University of Aeronautics and Astronautics
2018

Liaoning University
2017

Brigham and Women's Hospital
2009-2013

Harvard University
2012-2013

BACKGROUND: The decrease in S-nitrosoglutathione reductase (GSNOR) leads to an elevation of S-nitrosylation, thereby exacerbating the progression cardiomyopathy response hemodynamic stress. However, mechanisms under GSNOR remain unclear. Here, we identify NEDD4 (neuronal precursor cell expressed developmentally downregulated 4) as a novel molecule that plays crucial role pathogenesis pressure overload–induced cardiac hypertrophy, by modulating levels, demonstrating significant therapeutic...

10.1161/circresaha.124.324872 article EN Circulation Research 2025-01-23

Mitoferrin-1 (Mfrn1; Slc25a37), a member of the solute carrier family localized in mitochondrial inner membrane, functions as an essential iron importer for synthesis heme and iron-sulfur clusters erythroblasts. The biochemistry Mfrn1-mediated transport into mitochondria, however, is poorly understood. Here, we used strategy vivo epitope-tagging affinity purification mass spectrometry to investigate homeostasis. Abcb10, membrane ATP-binding cassette transporter highly induced during...

10.1073/pnas.0904519106 article EN Proceedings of the National Academy of Sciences 2009-09-05

10.1016/j.camwa.2013.06.006 article EN publisher-specific-oa Computers & Mathematics with Applications 2013-07-05

10.1016/j.cnsns.2018.02.007 article EN Communications in Nonlinear Science and Numerical Simulation 2018-02-23

Article Investigation on Fractional and Fractal Derivative Relaxation- Oscillation Models was published January 1, 2010 in the journal International Journal of Nonlinear Sciences Numerical Simulation (volume 11, issue 1).

10.1515/ijnsns.2010.11.1.3 article EN International Journal of Nonlinear Sciences and Numerical Simulation 2010-01-01

Fractional order nonlinear Klein‐Gordon equations (KGEs) have been widely studied in the fields like; optics, solid state physics, and quantum field theory. In this article, with help of Sumudu decomposition method (SDM), a numerical scheme is developed for solution fractional KGEs involving Caputo's derivative. The coupled provides us very efficient terms convergent series. iterative applied to illustrative examples demonstration applications.

10.1002/mma.5375 article EN Mathematical Methods in the Applied Sciences 2018-11-18

A sampling theorem for regular in shift-invariant subspaces is established. The sufficient-necessary condition which it holds found. Then, the modified to shift by using Zak transform. Finally, some examples are presented show generality of theorem.

10.1109/78.720386 article EN IEEE Transactions on Signal Processing 1998-01-01

Lysine succinylation is an extremely important protein post-translational modification that plays a fundamental role in regulating various biological reactions, and dysfunction of this process associated with number diseases. Thus, determining which Lys residues uncharacterized sequence are succinylated underpins both basic research drug development endeavors. To solve problem, we have developed predictor called pSuc-PseRat. The features the pSuc-PseRat derived from two aspects: (1) binary...

10.1089/cmb.2016.0206 article EN Journal of Computational Biology 2017-07-06

Different lipid sources differ in the fatty acid profiles and differently affect growth performance as well immune function of broilers. The influences different dietary on performance, nutrient digestibility, blood T lymphocyte population, cardiac antioxidant status were investigated A total 360 one-day-old male broilers (BW = 44 ± 3 g) randomized into treatment groups, consisting 6 replicates with 20 birds each group. Broilers received standard diets supplemented 5% (wt/wt) lard (LD, a...

10.1016/j.aninu.2018.04.004 article EN cc-by-nc-nd Animal nutrition 2018-04-25

An atmospheric-pressure microplasma plume of diameter 10 μm is generated inside a long tube. The length the reaches as much 2 cm. First, with assistance an air dielectric barrier discharge (DBD), ignition voltage decreases from 40 kV to 23.6 kV. Second, although current density high (1.2−7.6) × 104 A cm−2, comparable in transient spark discharge, non-thermal. Third, it interesting observe that amplitude positive cycle applied lower than negative voltage. Fourth, electron measured by Stark...

10.1088/2058-6272/aad082 article EN Plasma Science and Technology 2018-07-02

This article study the influences of fermented wheat germ on rats in terms blood glucose, insulin level, serum lipid cholesterol metabolism, triglyceride metabolism and enzyme activity basis high-fat rat model. High fat were fed for modeling, then liver collected after sacrifice. Total (TC), (TG), total superoxide dismutase (SOD), Superoxide (T-SOD), glutathione peroxidase (GSH-PX), Malonic dialdehyde (MDA), lecithin acyltransferase (lecithin cholesterol), Acyltransferase (LCAT), LDL-C,...

10.1590/fst.57222 article EN Food Science and Technology 2022-01-01

A new flavanol, named songarin (1), was isolated from Cynomorium songaricum Rupr. The structure established on the basis of spectroscopic methods including 2D NMR techniques. Compound 1 displayed protective effect against d-galactosamine-induced HepG2 damage and reduced 58.64% to 22.26%.

10.1080/10286020.2013.774765 article EN Journal of Asian Natural Products Research 2013-03-06

This paper introduces a new Matlab toolbox for the numerical solution of power law frequency-dependent damped vibration and dissipative wave equations involving positive fractional time derivative. The classical integer-order derivative models have long encountered huge difficulty in describing such complex thermoviscous behaviors, particularly if broadband excitation is involved. Recent decades seen growing interest modeling anomalous viscosity. Among various models, model has clear...

10.1177/1077546313479636 article EN Journal of Vibration and Control 2013-05-07

Hepatic microsomal xenobiotic metabolizing enzyme activities of laboratory animals can be modulated by Dietary restriction (DR). the modulation affect metabolic activation chemical carcinogens. Acute DR (60% food consumption ad libitum (AL)-fed mice

10.3109/01480549609002194 article EN Drug and Chemical Toxicology 1996-01-01

In the title complex, {[Cu 2 (C 12 H 10 N )(C 4 18 15 P) ](BF ) } n , cations form a linear chain, and are bridged by 1,2-bis(4-pyridyl)ethene pyridine-2-carbaldehyde azine. Each Cu I atom is coordinated one P of PPh 3 ligand, two atoms azine bridging ligand ligand. There crystallographic centre symmetry at mid-point N—N bond.

10.1107/s160053680600818x article EN Acta Crystallographica Section E Structure Reports Online 2006-03-10

To study the characteristics of intestinal absorption psoralen and isopsoralen Xianlinggubao capsule, compare capsule prepared by different technologies.Non everted gut sac method was applied to investigate influence sites drug concentration on absorption, which were determined HPLC.Although rate constants in duodenum more than that jejunum ileum, there no significance difference between them. The kept at same level when concentrations solution middle low level, while constant high...

10.4268/cjcmm20110809 article EN China Journal of Chinese Materia Medica 2011-04-15
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