A5112545212- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Advanced oxidation water treatment
- Water Treatment and Disinfection
- Nanoparticle-Based Drug Delivery
- Advanced Photonic Communication Systems
- Neuropeptides and Animal Physiology
- Photonic and Optical Devices
- Advanced Fiber Laser Technologies
- Biochemical and Structural Characterization
- Photodynamic Therapy Research Studies
- Probiotics and Fermented Foods
- GABA and Rice Research
- Glaucoma and retinal disorders
- Electrostatic Discharge in Electronics
- Adversarial Robustness in Machine Learning
- Pharmaceutical and Antibiotic Environmental Impacts
- Microbial Metabolic Engineering and Bioproduction
- Natural product bioactivities and synthesis
- Ocular Surface and Contact Lens
- Water Quality Monitoring and Analysis
- High voltage insulation and dielectric phenomena
- Microencapsulation and Drying Processes
- Occupational Health and Safety Research
- Chemical Safety and Risk Management
Hebei University
2023-2024
Shanghai University of Electric Power
2022-2024
Institute of Modern Physics
2024
Chinese Academy of Sciences
2024
CSPC Pharmaceutical Group
2024
University of Chinese Academy of Sciences
2024
Beijing University of Chinese Medicine
2016-2024
Anhui Medical University
2023-2024
University of Electronic Science and Technology of China
2021-2023
Xi'an Jiaotong University
2023
Activatable prodrugs have drawn considerable attention for cancer cell ablation owing to their high specificity in drug delivery systems. However, phototheranostic with dual organelle-targeting and synergistic effects are still rare due low intelligence of structures. Besides, the membrane, exocytosis, diffusional hindrance by extracellular matrix reduce uptake. Moreover, up-regulation heat shock protein short singlet-oxygen lifetime cells hamper photo-ablation efficacy, especially...
Traditional chemotherapy is one of the main methods cancer treatment, which largely limited by severe side effects and frequent development multi-drug resistance cells. Antimicrobial peptides (AMPs) with high efficiency low toxicity, as most promising new drugs to replace chemoradiotherapy, have become a current research hotspot, attracting attention worldwide researchers. AMPs are natural-source small from innate immune system, certain can selectively kill broad spectrum cells while...
Purpose Maytansine (DM1) is a potent anticancer drug and limited in clinical application due to its poor water solubility toxic side effects. Zein widely used nano delivery systems good biocompatibility. In this study, we prepared DM1-loaded zein nanoparticles (ZNPs) achieve tumor targeting reduce effects of DM1. Methods: ZNPs were by phase separation Box-Behnken design was optimize the formulation. Then, confocal fluorescence microscope flow cytometry determine cellular uptake ZNPs. A549...
Tumor metastasis and recurrence are recognized to be the main causes of failure in cancer treatment. To address these issues, an "all one" "one for all" nanoplatform was established combined "chemo-immuno-photothermal" therapy with expectation improve antitumor efficacy. Herein, Docetaxel (DTX, a chemo-agent) cynomorium songaricum polysaccharide (CSP, immunomodulator) were loaded into zein nanoparticles coated by green tea polyphenols/iron coordination complex (GTP/FeIII, photothermal...
Chemotherapeutic drugs are often ineffective due to the delivery. Local chemotherapy, which has high drug concentration, low systemic toxicity, and long duration, shown excellent potential. Cationic antimicrobial peptides have been proved enhance tumor cells' uptake of chemotherapeutic through membrane-breaking effect. In this study, we designed developed a thermosensitive gel co-loaded with Dermaseptin-PP paclitaxel liposomes increase local chemotherapy.The were prepared. Then, it was in...
Lung cancer is the major cause of deaths worldwide, and it has highest incidence mortality rate any among men women in China. The first-line therapy for lung treatment platinum-based chemotherapy drugs such as cisplatin. However, application present chemotherapies limited by severe side effects, which stimulates discovery new with anti-tumor mechanisms fewer effects. Beneficially, many antimicrobial peptides (AMPs) from frog skin have been reported to exhibit potent anti-cancer activities...
Avoiding the low specificity of phototheranostic reagents at tumor site is a major challenge in cancer phototherapy. Meanwhile, angiogenesis not only premise occurrence but also basis growth, invasion, and metastasis, making it an ideal strategy for therapy. Herein, biomimetic cell membrane-coated nanodrugs (mBPP NPs) have been prepared by integrating (i) homotypic membranes evading immune phagocytosis to increase drug accumulation, (ii) protocatechuic acid vascular targeting along with...
We propose and demonstrate a dual-band Fourier domain mode-locked optoelectronic oscillator (FDML-OEO) for simultaneously generating two frequency-agile microwave signals by deploying rapidly tunable independently reconfigurable bandpass filters (TBF) parallelly placed in RF feedback loops. By adjusting the drive of TBFs, linearly chirped waveforms (LCMWs) can be generated. In particular, driving TBFs with different waveforms, Costas-coded linear frequency modulation (LFMWs) coding patterns...
Introduction Sweet sorghum juice is a typical production feedstock for natural, eco-friendly sweeteners and beverages. Clostridium tyrobutyricum one of the widely used microorganisms in food industry, its principal product, bio-butyric acid an important additive. There are no published reports producing butyric using SSJ as sole substrate without adding exogenous substances, which could reach food-additive grade. This study focuses on tailoring cost-effective, safe, sustainable process...
ABSTRACT The environmental health risks of acetochlor (ACE) have received widespread attention. removal ACE via the ultraviolet/persulfate (UV/PS) process was investigated in this study. degradation UV/PS fitted pseudo-first-order kinetics. can be effectively removed pH range 5.0–9.0. In addition, efficiency increases with increase PS concentration. experimental and calculation results prove that contributions UV irradiation, sulfate radicals (SO4•-) hydroxyl (HO·) were 40, 52.1, 6.43%,...
Lignocellulose is a renewable and sustainable resource used to produce second-generation biofuel ethanol cope with the energy crisis. Furfural most toxic inhibitor of Saccharomyces cerevisiae cells produced during lignocellulose treatment, can reduce ability S. utilize lignocellulose, resulting in low bioethanol yield. In this study, multiple rounds progressive ionizing radiation was combined adaptive laboratory evolution improve furfural tolerance increase yield ethanol. strategy X-ray...
To find a stable, inexpensive, and reliable method to produce rat meibomian gland dysfunction (MGD) model.We inserted slim guidewires into the orifices of twelve Brown Norway rats fulgurized every guidewire destroy part gland. We then observed morphological changes in eyelid margin, compared data tear breakup time (TBUT), Schirmer I test, corneal fluorescence staining scores at different times (1, 2, 4, 6wk). pathological cornea, conjunctiva gland, we used real-time polymerase chain reaction...
Dermaseptin-PP is a newly discovered anticancer peptide with unique antitumour mechanism and remarkable effect. However, this α-helix risks haemolysis when used at high doses, which limits its further application. This study aims to prepare pH-responsive liposome, Der-loaded-pHSL, using nanotechnology avoid the risk of increase accumulation in tumour sites enhance efficacy reduce toxicity.The characterisation Der-loaded-pHSL was carried out employing preparation. The effect inhibition were...
Background Short-term unplanned readmission is always neglected, especially for elderly patients with coronary heart disease (CHD). However, tools to predict are lacking. This study aimed establish the most effective predictive model 7-day in CHD using machine learning (ML) algorithms. Methods The detailed clinical data of were collected retrospectively. Five ML algorithms, including extreme gradient boosting (XGB), random forest, multilayer perceptron, categorical boosting, and logistic...
Chemical constituents in extract of Scrophulariae Radix and their metabolites rat plasma after oral administration were identified by HPLC-LTQ-Orbitrap. Samples separated a Venusil MP C₁₈ column using binary gradient elution. The information on the total ion chromatogram, extraction chromatogram mass spectrogram negative mode synthetically analyzed comparing retention time, MS MS/MS spectra with literature data some reference standards to conduct qualitative study vivo vitro. Totally 37...