A5100764803- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Ocular Surface and Contact Lens
- Antimicrobial Peptides and Activities
- Dendrimers and Hyperbranched Polymers
- Glycosylation and Glycoproteins Research
- Bacterial biofilms and quorum sensing
- Advancements in Transdermal Drug Delivery
- Immune Cell Function and Interaction
- Advanced Photocatalysis Techniques
- T-cell and B-cell Immunology
- Infant Nutrition and Health
- Ammonia Synthesis and Nitrogen Reduction
- Growth Hormone and Insulin-like Growth Factors
- Electrocatalysts for Energy Conversion
- Antimicrobial agents and applications
- Glioma Diagnosis and Treatment
- Bone Tissue Engineering Materials
- Fuel Cells and Related Materials
- Bee Products Chemical Analysis
- Copper-based nanomaterials and applications
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
Binzhou Medical University
2016-2023
Binzhou University
2016-2023
Xi'an University of Science and Technology
2022
China-Japan Friendship Hospital
2020
To improve the oral efficiency of exenatide, we prepared polyethylene glycol-poly(lactic-co-glycolic acid) (PEG-PLGA) NPs modified with Fc (NPs-Fc) for exenatide delivery. Exenatide was encapsulated into by w/o/w emulsion-solvent evaporation method. The particle size NPs-Fc approximately 30 nm larger than that unmodified polydispersity indices in a narrow range (PDIs; PDI < 0.3) as detected DLS, and highest encapsulation greater 80%. Fc-conjugated permeated Caco-2 cells faster to extent...
Successful treatment of infectious bone defect remains a major challenge in the orthopaedic field. At present, conventional for defects is surgical debridement and long-term systemic antibiotic use. It necessary to develop new strategy achieve effective regeneration local anti-infection defects. Firstly, vancomycin / poly (lactic acid-glycolic acid) sustained release microspheres (VAN/PLGA-MS) were prepared. Then, through dual-nozzle 3D printing technology, VAN/PLGA-MS was uniformly loaded...
Gemcitabine (GEM) and paclitaxel (PTX) are effective combination anticancer agents against non-small-cell lung cancer (NSCLC). At the present time, a main challenge of treatment is precision control that will maximize combined effects. Here, we report novel method to load GEM (hydrophilic) PTX (hydrophobic) into simplex tumor-targeted nanostructured lipid carriers (NLCs) for accurate ratio two drugs. We covalently preconjugated dual drugs through hydrolyzable ester linker form drug...
Background: Nanostructured lipid carriers (NLCs) are emerging as attractive drug in transdermal delivery. The surface modification of NLCs with cell-penetrating peptides (CPPs) can enhance the skin permeation drugs. Purpose: objective current study was to evaluate ability peptide (CPP) polyarginine translocate loaded lornoxicam (LN) into layers and its anti-inflammatory effect. Methods: were prepared using an emulsion evaporation low temperature solidification technique glyceryl...
Biofilm formation is one of the main reasons for persistent bacterial infections. Recently, pH-sensitive copolymers have fascinated incredible attention to tackle biofilm-related However, proper incorporation segments in polymer chains, which could significantly affect biofilms targeting ability, has not been particularly investigated. Herein, we synthesized three types based on poly (β-amino ester) (PAE), (lactic-co-glycolic acid) (PLA) and polyethylene glycol (PEG), PAE-PLA-mPEG (A-L-E),...
As we enter the post-antibiotic era, rise of antibiotic-resistant pathogenic bacteria is becoming a serious threat to public health. This problem further complicated by biofilms, for which current treatment options are limited.To tackle this challenge, propose novel approach that involves use photodynamic cationic pH-sensitive liposomes loaded with ultra-small copper oxide (Ce6@Lipo/UCONs) effectively eliminate drug-resistant and eradicate biofilms while minimizing safety concerns risk...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by abnormal activation of T cells and caused an imbalance in the production clearance apoptotic cells. We previously showed that transcription regulator Bach2 regulated B‐cell SLE. Here, we investigated whether was also involved Th9 cell differentiation found proportion enhanced peripheral blood mononuclear (PBMC) SLE patients. The PBMC CD4 + patients exhibited decrease expression increase IL‐9 expression....
Daily subcutaneous injection of human growth hormone has been used for the treatment deficiency and failure but led to poor patient compliance renal toxicity. Thus, it is crucial develop favorable delivery systems improve compliance. In present study, increase oral bioavailability compliance, enteric-coated capsules filled with monomethoxyl poly(ethylene glycol)-b-poly(L-lactide-co-glycolide) nanoparticles were prepared facilitate delivery. The less than 100 nm in size, exhibited narrow...
Background: Ethosomes, a novel type of percutaneous drug delivery carrier with lipid bilayer structure, penetrate the skin barrier due to their deformability and malleability, presence ethanol that fluidizes lipids in skin. In order further enhance drugs through skin, penetration enhancers are widely used. Objective: The objective this work was develop an optimized formulation lornoxicam ethosomal gels, investigate permeability addition enhancers, evaluate invivo pharmacodynamics these...
Regulating photogenerated charge carrier transfer kinetics in multi-component heterostructure by surface-interface design is of great significance for accelerating efficiently photocatalytic hydrogen evolution reaction. Herein, a novel binary CoSe2/CNNS composite successfully fabricated successive high-temperature calcination method g-C3N4 followed in-situ hot injection process CoSe2 the first time. The optimal 7.5% reaches moderate production rate 1386.8 µmol·g-1·h-1 and exhibits good...