A5102332852- Metaheuristic Optimization Algorithms Research
- RNA modifications and cancer
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Advanced Multi-Objective Optimization Algorithms
- Nanoparticle-Based Drug Delivery
- Glycosylation and Glycoproteins Research
- Scheduling and Optimization Algorithms
- Immune cells in cancer
- Advanced Manufacturing and Logistics Optimization
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Catalytic Processes in Materials Science
- Assembly Line Balancing Optimization
- Cancer Immunotherapy and Biomarkers
- Nanoparticles: synthesis and applications
- Gene expression and cancer classification
- Immune Cell Function and Interaction
- Effects of Radiation Exposure
- interferon and immune responses
- Evolutionary Algorithms and Applications
- Lung Cancer Research Studies
- Chromosomal and Genetic Variations
- PARP inhibition in cancer therapy
- Optimization and Mathematical Programming
Affiliated Hospital of Youjiang Medical University for Nationalities
2023-2024
Wuhan University
2018-2023
Renmin Hospital of Wuhan University
2021-2023
Northeast Normal University
2016-2022
Zhongnan Hospital of Wuhan University
2018-2022
Tianjin University of Technology
2016-2020
Hubei Cancer Hospital
2019
Cancer Clinic
2019
Guangdong University of Technology
2016-2019
Minerva Foundation
2014
Effects of green-synthesized silver nanoparticles on lung cancer cells in vitro and grown as xenograft tumors vivo Yan He,1,* Zhiyun Du,1,* Shijing Ma,1 Yue Liu,2 Dongli Li,1 Huarong Huang,1 Sen Jiang,1 Shupeng Cheng,1 Wenjing Wu,1 Kun Zhang,1 Xi Zheng1,2 1Allan H Conney Laboratory for Anticancer Drug Research, School Chemical Engineering Light Industry, Guandong University Technology, Guangzhou, People’s Republic China; 2Susan Lehman Cullman Cancer Department Biology, Ernest Mario...
Metal nanoparticles, particularly silver nanoparticles (AgNPs), are developing more important roles as diagnostic and therapeutic agents for cancers with the improvement of eco-friendly synthesis methods. This study demonstrates biosynthesis, antibacterial activity, anticancer effects using Dimocarpus Longan Lour. peel aqueous extract. The AgNPs were characterized by UV-vis absorption spectroscopy, X-ray diffraction (XRD), high-resolution transmission electron microscopy (HRTEM), scanning...
The multiobjective permutation flow shop scheduling problem with sequence dependent setup times has been an object of investigations for decades. This widely studied from the theory links sophisticated solution algorithms moderate real world applications. paper presents a novel discrete artificial bee colony algorithm based decomposition, called MODABC/D, to solve flowshop objective minimize makespan and total flowtime. First, in order make standard problem, is proposed on perturbation...
The molecular interactions between compound and polymeric carriers are expected to highly contribute high drug load good physical stability of solid dispersions. In this study, a series amorphous dispersions (ASD) Curcumin (Cur) were prepared with different polymers by the solvent evaporation method. With carrier polyvinylpyrrolidone (PVP), dispersion system exhibits better solubility than that poloxamers HP-β-CD due strong drug-polymer interaction. drug/polymer interaction their binding...
Non-small cell lung cancer (NSCLC) has high mortality rates worldwide. Agrin contributes to immune synapse information and is involved in tumor metastasis. However, its roles NSCLC microenvironment remain unclear. This study examined the effects underlying mechanisms of tumor-infiltrated cells. Clinical tissue samples were used confirm bioinformatic predictions. cells investigate on cycle proliferation, as well invasion migration. Tumor xenograft mouse model was growth regulatory T (Tregs)...
Purpose To evaluate the performance of a combined clinical-radiomics model using multiple machine learning approaches for predicting pathological differentiation in hepatocellular carcinoma (HCC). Material and methods A total 196 patients with pathologically confirmed HCC, who underwent preoperative computed tomography (CT) were retrospectively enrolled (training: n = 156; validation: 40). The modelling process included folowing: (1) clinical construction through logistic regression analysis...
IL-22-producing CD4(+) T helper cells (Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role Th22 in pathogenesis hepatocellular carcinoma (HCC). The aimed to determine biological function its effector IL-22 HCC patients.Forty-five patients 19 healthy controls were recruited their peripheral blood was collected. fresh tissues, adjacent tissues ten normal liver also Flow cytometry analysis used...
Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development.The roles of snoRNA 71A (SNORA71A) the progression non-small cell lung cancer (NSCLC) remained unclear.Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloaded to detect expression levels SNORA71A NSCLC tissues.The biological significance explored by loss-of-function analysis both vitro and vivo.Results: overexpressed tissues compared with...
The multiobjective permutation flowshop scheduling problem (MOPFSSP) is one of the most popular machine problems with extensive engineering relevance manufacturing systems. There have been many attempts at solving MOPFSSP using heuristic and meta-heuristic methods, such as evolutionary algorithm. In this paper, a novel memetic search algorithm (MMSA), proposed to solve makespan total flowtime. First, problem-specific Nawaz-Enscore-Hoam used initialize population enhance quality initial...
With the advancement of nanotechnology, various nanocomposites have been applied in diagnostics and treatment cancer.We synthetized FePt nanoparticles which were assembled on surface graphene oxide (GO).These novel FePt/GO nanosheets simultaneously act as a chemotherapy drug enhance radiosensitivity.In this study, transmission electron microscope, dynamic light scattering, X-ray photoelectron spectroscope Fourier transform infrared spectroscopy used to characterize morphology chemical...
Pneumonitis is a common adverse effect found in non-small cell lung cancer patients after radiotherapy or immune checkpoint inhibitor treatment. We investigated the effects of these two therapies, combined, tissue an orthotopic tumor-bearing mouse model. The mice received 8 Gy dose three times with without 200 µg anti-programmed death-1 (anti-PD-1) antibody intraperitoneal injection every days. Lung tissues were H&E stained to determine histological changes. serum levels cytokines, such as...
Radiation-induced lung injury (RILI) is one of the most common and fatal complications thoracic radiotherapy. Inflammatory cell infiltration, imbalance inflammatory cytokines, oxidative damage were reported to be involved during RILI pathogenesis, especially in early phase RILI. Nuclear factor-erythroid 2-related factor 2 (Nrf2) a key transcriptional regulator antioxidative cascades, regulates life span mice after administration irradiation. We investigated effects Nrf2 on inflammation using...
Monopulse antennas play an important role in realizing tracking radar. In this letter, we present improved cuckoo search (ICS) algorithm to optimize the difference patterns of monopulse antennas. order balance exploration and exploitation algorithm, two new schemes are incorporated into standard enrich searching behavior solution quality avoid being trapped local optimum. verify performance our proposed is tested with three different cases. The results these instances show that ICS...
Environmental/economic dispatch (EED) problems play a salient role in the power system, which can be defined as complex constrained optimization problem. Many different methods have been introduced to handle EED and got some inspiring positive results research. In this paper, new multiobjective global best artificial bee colony (ABC) algorithm is proposed tackle problems. To manipulate problem effectively, we propose ABC generate individual speed up convergence of algorithm. Afterwards,...
The production of nitric oxide (NO) is a key feature immunosuppressive myeloid cells, which impair T cell activation and proliferation via reversibly blocking interleukin-2 receptor signaling.NO mainly produced from L-arginine by inducible NO synthase (iNOS).Moreover, an essential element for behaviors.Impaired function further inhibits anti-tumor immunity promotes tumor progression.Previous studies indicated that radiotherapy activated immune responses in multiple tumors.However,...
Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) has a specific antitumour activity against many malignant tumours.However, more than half of lung cancer cells are resistant to TRAIL-relevant drugs.Trichosanthin (TCS) is traditional Chinese medicine with strong inhibitive effects on various malignancies.Nevertheless, its function TRAIL resistance not been revealed in non-small cell (NSCLC).To examine the molecular mechanisms TCS-induced sensitivity, we administrated TCS...
Many real-world problems can be transformed into multimodal functional optimization. Each of these may include several globally optimal solutions, rendering the solution problem progressively more difficult. In our study, we present a crowding artificial bee colony, called IABC, which exploits concepts and explores search solutions. A approach formed in niches is used to make it capable tracking maintaining multiple optima, resulting good convergence space with better chance locating optima....
Background: Recent advances in nanomedicine provided promising alternatives for tumor treatment to improve the survival and life quality of cancer patients.This study was designed explore insight mechanisms anti-tumor effects novel nanocomposites (NCs) MFP-FePt-GO with non-small cell lung (NSCLC).Methods: A chemical co-reduction method applied synthesis process NCs.The efficiency morphology NCs were measured spectroscope transmission electron microscope.Colony formation assay apoptosis...
Differential evolution algorithm is an effective and population-based global optimization algorithm, which has been successfully used in many different fields. In this paper, the proposed attempts to combine advantage of evolutionary local search find optimum solutions with low computational cost for single objective bilevel problem. For upper level optimization, a multi-population-based ensemble mutation method enhance convergence rate diversity maintenance. lower based on sequential...
The synergetic effect of chemoradiotherapy achievement is encouraging but significantly hampered by the prevalence hypoxia, leading to drug/radiation resistance in solid tumours. To address problem and improve efficiency cancer therapy, a lamellar-structure multifunctional graphene oxide (GO) drug-delivery system with an average size 243 nm, co-delivering metronidazole (MI), 5-fluorouracil (5-FU) FePt magnetic nanoparticles (MNPs), was successfully designed synthesized study. integration...