A5048552499- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Liver Disease Diagnosis and Treatment
- Neuroendocrine Tumor Research Advances
- Liver physiology and pathology
- Immune Cell Function and Interaction
- Cytokine Signaling Pathways and Interactions
- Ferroptosis and cancer prognosis
- Liver Disease and Transplantation
- Cancer Immunotherapy and Biomarkers
- Helicobacter pylori-related gastroenterology studies
- Immunotherapy and Immune Responses
- Psoriasis: Treatment and Pathogenesis
- Gastric Cancer Management and Outcomes
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Immune Response and Inflammation
- Cancer-related gene regulation
- Gastroesophageal reflux and treatments
- Esophageal and GI Pathology
- T-cell and B-cell Immunology
- Pancreatitis Pathology and Treatment
- Cancer Research and Treatments
First Affiliated Hospital of GuangXi Medical University
2016-2025
Guangxi Medical University
2016-2025
Compliant Concept
2020
Weatherford College
2020
National Natural Science Foundation of China
2020
Creative Commons
2020
Abstract Gefitinib efficiency in non-small-cell lung cancer (NSCLC) therapy is limited due to development of drug resistance. The molecular mechanisms gefitinib resistance remain still unclear. In this study, we first found that connexin 26 (Cx26) the predominant Cx isoform expressed various NSCLC cell lines. Then, two gefitinib-resistant (GR) lines, HCC827 GR and PC9 GR, from their parental cells were established. these cells, results showed correlated with changes cellular EMT phenotypes...
Background The diagnostic efficiency of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) cytology varies widely depending on the treatment method specimens. present study aimed to evaluate efficacy cell block (CB) immunohistochemistry, smear (SC), and liquid-based (LBC) in patients with pancreatic lesions without consulting an on-site cytopathologist. Methods This prospectively enrolled 72 lesions. EUS-FNA specimens were examined by SC, LBC, CB immunohistochemistry. 3 methods...
Resveratrol has been suggested to mediate liver fibrosis. The switch from classically M(LPS) alternatively activated M(IL-4) macrophages shows protect organs However, the mechanisms remain unclear. study aimed investigate whether resveratrol inhibited fibrosis by delivering IL-10 promote macrophage polarization in vitro and vivo. We observed that improved CCL4-induced fibrosis, upregulated Kupffer cells, increased expression of marks including Mrc1, Mrc2, CD163 Arg1, whereas it slightly...
Abstract IL-22 ameliorates liver fibrosis by inhibiting hepatic stellate cells (HSC), and loss of miR-200a is associated with the development fibrosis. The study aimed to investigate interplay between in regulating vivo vitro . We observed that significantly reduced proliferation HSC increased expression p-STAT3. β-catenin was identified as a target gene luciferase reporter assay, upregulation attenuated expression. treatment decreased HSC. p-STAT3 elevated while fibrotic rat after...
Abstract Ferroptosis is a newly-discovered cell death mechanism involved in the progression of various tumors, role noncoding RNAs (ncRNAs) it was relatively less explored. This study identified low levels recently studied long RNA (lncRNA), A2M-AS1, pancreatic cancer and suggested its positive correlation with overall survival time patients cancer. A2M-AS1 mainly localized cytoplasm, inhibiting cellular proliferation, migration, invasion as well tumor growth cells. Moreover, Erastin-induced...
ABSTRACT Resveratrol alleviates liver fibrosis in mice by upregulating IL‐10 to reprogram the macrophage phenotype; however, mechanism remains be elucidated. Building on our previous work, this study, we aimed determine role of TLR2/MyD88/ERK and NF‐κB/NLRP3 inflammasome pathways mediating effects resveratrol polarization. We investigated expression cytokines these a mouse model resveratrol‐treated macrophages. The results showed that TLR2, MyD88, ERK, NF‐κB1 tissues was increased fourth...
IL-22-producing CD4(+) T helper cells (Th22 cells) have been identified as major inducers of tissue inflammation and immune responses. Currently, no previous study explored the role Th22 in pathogenesis hepatocellular carcinoma (HCC). The aimed to determine biological function its effector IL-22 HCC patients.Forty-five patients 19 healthy controls were recruited their peripheral blood was collected. fresh tissues, adjacent tissues ten normal liver also Flow cytometry analysis used...
Abstract T helper 9 (Th9) cells, a recently recognized Th cell subset, are involved in autoimmune diseases. We aimed to investigate the role of Th9/interleukin-9 (IL-9) pathogenesis hepatic fibrosis. Th9 and Th17 cells were quantified chronic hepatitis B (CHB) patients with fibrosis, HBV-associated liver cirrhosis (LC) healthy controls (HC). The percentages concentrations IL-9 IL-17, as well expression TNF-α, IL-6, IL-4, IL-21, TGF-β1 IFN-γ significantly increased plasma CHB LC compared...
Abstract Background Gemcitabine is a cornerstone drug for the treatment of all stages pancreatic cancer and can prolong survival patients with cancer, but resistance to gemcitabine in hinders its efficacy. The overexpression Early growth response 1(EGR1) ductal adenocarcinoma as mechanism chemoresistance has not been explored. major mechanisms are related uptake, metabolism, action. One common causes tumor multidrug (MDR) chemotherapy cells that transporter proteins increase intracellular...
Background. Both IL-9 and miR-200a are involved in the pathogenesis of cancers; however, role pancreatic cancer possible underlying mechanisms remain unknown. The aim this study was to investigate effect on cells its interaction with miR-200a. Methods. Pancreatic (PANC-1 AsPC-1) were treated expression β-catenin measured. β-Catenin examined as a target gene cells. between determined by infecting mimics prior treatment then measuring expression. Results. significantly promoted proliferation,...
Purpose: Endoscopic ultrasound-guided fine-needle injection (EUS-FNI) offers a promising minimally invasive approach for locally targeted management of advanced pancreatic cancer. However, the efficacy is limited due to rapid plasma clearance chemotherapeutic agents. Injectable hydrogels can form drug release depots, which provide feasible solution optimizing chemotherapy through EUS-FNI. Methods: A delivery system was developed, consisting gemcitabine (GEM) and thermo-sensitive hydrogel...
The incidence of hypertriglyceridemia (HTG)-induced acute pancreatitis (AP) is steadily increasing in China, becoming the second leading cause AP. Clinical complications and outcomes associated with HTG-AP are generally more severe than those seen AP caused by other etiologies. closely linked to metabolic dysfunction frequently coexists syndrome or its components. However, impact components on clinical remains unclear.
No previous studies reported the association of IL-12 polymorphisms with osteosarcoma. We aimed to investigate in a Chinese population. IL-12A rs568408, rs2243115, and IL-12B rs3212227 were evaluated case-control study 106 osteosarcoma patients 210 health controls by using polymerase chain reaction-restriction fragment length polymorphism. Serum IL-12p40 levels measured enzyme-linked immunosorbent assay. The serum significantly higher than those (p<0.01). Genotypes rs568408 GA GA/AA, CC...
Abstract Background There have been many reports on biomarkers for predicting the severity of acute pancreatitis (AP), but few studies complications; some simple and inexpensive indicators, in particular, are worth exploring. Methods We retrospectively collected clinical data 809 AP patients, including medical history results routine blood tests, grouped them according to occurrence complications. Differences characteristics between groups with without complications were compared using t...