A5036639840- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Peptidase Inhibition and Analysis
- Immune cells in cancer
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Melanoma and MAPK Pathways
- Cancer, Hypoxia, and Metabolism
- RNA Research and Splicing
- Peroxisome Proliferator-Activated Receptors
- Cancer Cells and Metastasis
- Cervical Cancer and HPV Research
- Connexins and lens biology
- Immune Cell Function and Interaction
- Liver Disease Diagnosis and Treatment
- Natural product bioactivities and synthesis
- Glycosylation and Glycoproteins Research
Zhongda Hospital Southeast University
2025
Washington University in St. Louis
2025
Liaocheng University
2024
Guangxi Medical University
2013-2024
Guangxi University
2013-2024
Hebei Medical University
2020-2024
Fourth Hospital of Hebei Medical University
2020-2024
First Affiliated Hospital of GuangXi Medical University
2022-2024
Guangxi University of Chinese Medicine
2024
First People's Hospital of Kunshan
2022
Breast cancer is one of the most common malignancies and major cause cancer-related death in women. Although importance PIWI-interacting RNAs (piRNAs) has been increasingly recognized, few studies have explored functional mechanism piRNAs breast development progression.We examined top 20 highly expressed based on analysis TCGA data two patient cohorts to test roles cancer. The effects piRNA-36,712 malignant phenotypes chemosensitivity cells were detected vitro vivo. MS2-RIP reporter gene...
Conventional chemotherapy fails to cure metastatic hepatoma mainly due its high hepatotoxicity. Many plant-derived agents have been accepted effectively inhibit cell invasion. However, the investigation that whether effectual against invasive cells exert unexpected cytotoxicity in healthy hepatocytes has ignored. This study demonstrated berberine exhibited significant HepG2 through upregulation of reactive oxygen species (ROS) production but was ineffective normal Chang liver cells....
Abstract Gefitinib efficiency in non-small-cell lung cancer (NSCLC) therapy is limited due to development of drug resistance. The molecular mechanisms gefitinib resistance remain still unclear. In this study, we first found that connexin 26 (Cx26) the predominant Cx isoform expressed various NSCLC cell lines. Then, two gefitinib-resistant (GR) lines, HCC827 GR and PC9 GR, from their parental cells were established. these cells, results showed correlated with changes cellular EMT phenotypes...
Background/Aims: Gap junctions, which are assembled by connexins, can directly connect the cytoplasm of adjacent cells and enable gap junctional intercellular communication (GJIC) as well metabolic coupling between neighboring cells. Here, we investigated role connexin 43 (Cx43) its derived GJIC in interplay non-small cell lung cancer (NSCLC) cancer-associated fibroblasts (CAFs). Methods: CAFs NSCLC were co-cultured with direct contact separated using flow cytometry. Glucose uptake, lactate...
T cell infiltration into tumors is essential for successful immunotherapy against solid tumors. Herein, we found that the expression of hyaluronic acid synthases (HAS) was negatively correlated with patient survival in multiple types including gastric cancer. HA impeded vitro anti-tumor activities anti-mesothelin (MSLN) chimeric antigen receptor cells (CAR-T cells) cancer by restricting CAR-T mobility . We then constructed a secreted form human hyaluronidase PH20 (termed sPH20-IgG2)...
Immunogenic cell death (ICD)-mediated immunization strategies have great potential against breast cancer. However, traditional neglect the increase in immunosuppressive metabolite, adenosine (ADO), during ICD, leading to insufficient therapeutic outcomes. In this study, it is found that A2A receptor (A2AR) significantly expressed cancer and positively associated with regulatory T (Treg) cells. Herein, a strategy combining Fe/Mo-based lipid peroxidation (LPO) nanoamplifiers A2AR blockade...
Abstract Tumor-associated factors released by cancer cells can promote immune suppression and tolerance to radiation or therapy. Squamous cell carcinoma antigen (SCCA) is a tumor-associated cells. In cervical cancer, elevated pre-treatment SCCA in the serum seen 28-88% of patients these are more likely experience treatment resistance recurrence. The poor prognosis for with shows need improve strategies. Here, we aim understand mechanism action circulating tumor progression response...
To explore the relationship between tumor necrosis factor receptor-associated 6 (TRAF6) and clinicopathological features in HCC as well its biological function.Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) their corresponding non-tumor tissues, 37 cirrhosis 33 normal tissues. The expression of TRAF6 was assessed by immunohistochemistry. Then, analysis correlations parameters conducted. Furtherer, vitro experiments on HepG2 Hep3B cells performed to...
Abstract Background Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide and tends to be detected at an advanced stage. More effective biomarkers for HCC screening prognosis assessment are needed mechanisms require further exploration. The role MAOA in has not been intensively investigated. Methods In‐house tissue microarrays, genechips, RNAsequencing datasets were integrated explore expression status clinical value HCC. Immunohistochemical staining was utilized...
Abstract Background MiR-182-5p, a cancer-related microRNA (miRNA), modulates tumorigenesis and patient outcomes in various human malignances. This study interroted the clinicopathological significance molecular mechanisms of miR-182-5p non-small cell lung cancer (NSCLC). Methods The clinical NSCLC subtypes was determined based on an analysis 124 samples (lung adenocarcinomas [LUADs], n = 101; squamous carcinomas [LUSCs], 23) obtained from patients paired noncancer tissues data public...
Transcription Factor E2F-1 plays a critical role in cell cycle regulation and other biological processes cells. However whether or not it is involved the multi-drug resistance (MDR) process of gastric cancer has been fully elucidated yet. To explore MDR vitro vivo, cisplatin-resistant line with stable downregulation was established. shRNA led to endogenous mRNA protein. It significantly promoted sensitivity SGC7901/DDP cells cisplatin, doxorubicin, fluorouracil. Flow cytometry confirmed that...
Matrine has been used in anti-inflammatory and anticancer therapies for a long time. However, the antimetastatic effect molecular mechanism(s) of matrine on osteosarcoma are still unclear. Therefore, aim this study was to assess effects related cells. In study, we found that inhibited proliferation cells vivo vitro tumor cell metastasis at cytotoxic doses. also decreased expression matrix metalloproteinases-2 9, p50 p65 nuclear translocation, phosphorylated level I-κ-B (IκB)-β. addition,...
Due to the lack of effective early diagnostic measures and treatment methods, bladder cancer has become a malignant tumor that seriously threatens people's lives health. Here, we reported LINC00162, super-enhancer long noncoding RNA, was highly expressed in cells tissues. And LINC00162 negatively correlated with neighboring PTTG1IP expression. Knocking down expression can inhibit proliferative activity growth transplanted tumors vivo, while knocking could restore cells. In addition, both...