A5020760830- Cell Adhesion Molecules Research
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Peptidase Inhibition and Analysis
- Signaling Pathways in Disease
- RNA modifications and cancer
- Wnt/β-catenin signaling in development and cancer
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- FOXO transcription factor regulation
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Reproductive tract infections research
- Phagocytosis and Immune Regulation
- Chemokine receptors and signaling
- Bioinformatics and Genomic Networks
- RNA Research and Splicing
- Endometrial and Cervical Cancer Treatments
- S100 Proteins and Annexins
- Peroxisome Proliferator-Activated Receptors
- Global Cancer Incidence and Screening
- Lung Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Sphingolipid Metabolism and Signaling
West China Medical Center of Sichuan University
2024-2025
Sichuan University
2024
West China Hospital of Sichuan University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Shanghai Jiao Tong University
2024
First Affiliated Hospital of GuangXi Medical University
2019-2023
Guangxi Medical University
2019-2023
Hainan Medical University
2022
Lanzhou University
2019
The introns of the gene encoding long noncoding RNA (lncRNA) GAS5 host up to 10 C/D box small nucleolar RNAs (snoRNAs). However, whether there is a regulatory and functional relationship between these snoRNAs unknown. Here, we show that expression SNORD80, but not other snoRNAs, parallels regulated alongside in response cellular stress. 2′-O-methylation at A496 site, located within segment complementing conserved RNA-binding region on promotes stability consequent upregulation. This...
Recently, Differential Fault Attacks (DFAs) have proven highly effective against stream ciphers designed for Hybrid Homomorphic Encryption (HHE). In this work, we present a table-based DFA framework called the shortcut attack, which generalizes attack proposed by Wang and Tang on cipher Elisabeth. The applies to broad sub-family of following Group Filter Permutator (GFP) paradigm enhances previous DFAs improving both fault identification path generation steps. Notably, circumvents issue...
The histone deacetylase inhibitor MS275 (Entinostat) demonstrates anti-tumor effects against various types of solid tumors in vitro. But its effectiveness clinical trials is limited. underlying reasons remain to be determined. purpose this study was explore how enhance the colorectal cancer (CRC). Our data showed that inhibited CRC cell proliferation and induced apoptosis, irrespective gene mutation status. However, did not effectively suppress tumor growth AOM-DSS model as observed...
Background Worldwide, lung squamous cell carcinoma (LUSC) has wreaked havoc on humanity. Matrix metallopeptidase 12 ( MMP12 ) plays an essential role in a variety of cancers. This study aimed to reveal the expression, clinical significance, and potential molecular mechanisms LUSC. Methods There were 2,738 messenger RNA (mRNA) samples from several multicenter databases used detect expression LUSC, 125 tissue validated by immunohistochemistry (IHC) experiments. Receiver operator characteristic...
Lysophosphatidic acid (LPA), a simple water‑soluble glycerophospholipid with growth factor‑like activity, regulates certain behaviors of multiple cancer types by binding to its receptor, LPA receptor 2 (LPA2). Notch1 is key mediator in human cell types. The association between LPA2 and gastric cells not well known. present study aimed investigate the function controlling migration invasion activities SGC‑7901 following stimulation LPA. It was revealed that may stimulate expression Hes family...
Abstract Background Hepatocellular carcinoma (HCC) remains one of the most common cancers worldwide and tends to be detected at an advanced stage. More effective biomarkers for HCC screening prognosis assessment are needed mechanisms require further exploration. The role MAOA in has not been intensively investigated. Methods In‐house tissue microarrays, genechips, RNAsequencing datasets were integrated explore expression status clinical value HCC. Immunohistochemical staining was utilized...
Abstract Background The situation faced by breast cancer patients, especially those with triple-negative cancer, is still grave. More effective therapeutic targets are needed to optimize the clinical management of cancer. Although collagen type VIII alpha 1 chain (COL8A1) has been shown be downregulated in BRIP1-knockdown cells, its role remains unknown. Methods Gene microarrays and mRNA sequencing data were downloaded integrated into larger matrices based on various platforms. Therefore,...
Breast cancer (BC) has a complex etiology and pathogenesis, is the most common malignant tumor type in females, USA 2018, yet its relevant molecular mechanisms remain largely unknown. The collagen V α‑1 chain (COL5A1) gene differentially expressed renal ovarian cancer. Using bioinformatics methods, COL5A1 was determined to also be significant BC, but association with BC not been sufficiently reported. microarray clinical data were collected from Gene Expression Omnibus, Cancer Genome Atlas...
Cyclin-dependent kinase inhibitor 2C (CDKN2C) was identified to participate in the occurrence and development of multiple cancers; however, its roles small cell lung carcinoma (SCLC) remain unclear.Differential expression analysis CDKN2C between SCLC non-SCLC were performed based on 937 samples from centers. The prognosis effects patients with detected using both Kaplan-Meier curves log-rank tests. Using receiver-operating characteristic curves, whether made it feasible distinguish...
The impossible boomerang (IB) attack was first introduced by Lu in his doctoral thesis and subsequently published at DCC 2011. IB is a variant of the differential (ID) incorporating idea attack. In this paper, we revisit attack, introduce incompatibility two characteristics to construction an distinguisher. With our methodology, all constructions distinguisher are represented unified manner. Moreover, show that related-(twea)key distinguishers possess more freedom than ones ID so it can...
The coronavirus disease 2019 (COVID-19) pandemic is disrupting routine medical care of cancer patients, including those who have or are undergoing screening. In this study, breast management during the COVID-19 (BCMP) reviewed, and research trends BCMP evaluated by quantitative qualitative evaluation.In published studies relating to from 1 January 2020 April 2022 were searched Web Science database (WoS). Bibliometric indicators consisted publications, hotspots, keywords, authors, journals,...
Abstract Background Little is known about the relationship between integrin subunit alpha V ( ITGAV ) and cancers, including small cell lung cancer (SCLC). Methods Using large sample size from multiple sources, clinical roles of expression in SCLC were explored using differential analysis, receiver operating characteristic curves, Kaplan–Meier etc. Results Decreased mRNA (SMD = − 1.05) increased protein levels detected n 865). Transcription factors—ZEB2, IK2F1, EGR2—may regulate SCLC, as...
The clinical progression of small-cell lung cancer (SCLC) remains pessimistic. aim the present study was to promote understanding significance and mechanism O-linked N-acetylglucosamine (GlcNAc) transferase (OGT) in SCLC. Wilcoxon tests, standardized mean difference (SMD), Kruskal-Wallis tests were utilized compare OGT level differences among experimental control groups. univariate Cox regression analysis, Kaplan-Meier curves, receiver operating characteristic curves applied determine OGT's...
Abstract The histone deacetylase inhibitor MS275 (Entinostat) demonstrates anti-tumor effects against various types of solid tumors in vitro . But its effectiveness clinical trials is limited. underlying reasons remain to be determined. purpose this study was explore how enhance the colorectal cancer(CRC). Our data showed that inhibited CRC cell proliferation and induced apoptosis, irrespective gene mutation status. However, did not effectively suppress tumor growth AOM-DSS model as observed...
To investigate the expression of inositol polyphosphate 4-phosphatase type Ⅱ B (INPP4B) in colorectal cancer (CRC) and relevant clinical significance, to determine relationship between INPP4B matrix metallopeptidase 7 (MMP7) CRC cells, make preliminary exploration effects on proliferation migration cells mechanisms involved.
Abstract Background Thyroid cancer (TC) is the most common endocrine malignancy; basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify change of BSG expression TC its possible potential mechanism. Methods The levels were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays, literatures. Integrated analysis performed determined comprehensively. Gene...
The molecular mechanisms and signal pathways of ferroptosis in hepatoblastoma (HB) have not yet been clarified. In previous studies, activating transcription factor 3 (ATF3) was reported to be correlated with several tumors, but the clinical significance ATF3 has never determined. Herein, we investigated clinicopathological value regulating HB.The mRNA microarray RNA-sequencing data 402 samples from our hospital public databases were used estimate expression assess its role HB. standard mean...
Abstract Background Thyroid cancer (TC) is the most common endocrine malignancy, Basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify change of BSG expression TC its possible potential mechanism. Methods The levels were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays literatures. Integrated analysis performed determined comprehensively. gene...
Abstract Background: Thyroid cancer (TC) is the most common endocrine malignancy, Basigin (also known as BSG) plays a crucial role in tumor cell invasion, metastasis, and angiogenesis. This study was designed to identify change of BSG expression TC its possible potential mechanism. Methods: The levels were demonstrated using data collected from in-house immunohistochemical (IHC), RNA-sequencing (RNA-seq), microarrays literatures. Integrated analysis performed determined comprehensively. gene...
Abstract BackgroundEsophageal squamous cell carcinoma (ESCC) ranks the sixth in mortality rates cancers due to a lack of specific target diagnosis and treatment early stages. Although Forkhead box M1 (FOXM1) has been reported be differentially expressed ESCC, its clinical role function ESCC remained unclarified.MethodsData from our hospital public databases (n = 1906) were combined estimate how FOXM1 overexpression showed discriminatory ability between non-ESCC esophageal tissues. Downstream...
Abstract Background: Little is known about the relationship between integrin subunit alpha V ( ITGAV ) and cancers. Materials & Methods: Using large sample size from multiple sources, clinical roles of expression in pan-cancer were explored. Results: Upregulated mRNA was revealed cancers p < .05). Decreased (SMD = −1.05) increased protein levels detected small cell lung cancer (SCLC) n 865). made it feasible to distinguish non-cancers (e.g., for SCLC non-SCLC, AUC 0.88, sensitivity...
Purpose: Our purpose was to systematically appraise the clinicopathological significance and explore molecular bases of CKS2 in endometrial carcinoma. Patients Methods: We measured using diverse methods public RNA-seq, microarrays, in-house tissue microarrays investigate basis carcinoma through upstream transcriptional analysis, immune infiltration correlation co-expression analysis. Results: Both analysis for RNA-seq plus microarray data confirmed significant overexpression a total 1,021...