A5054684996- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Advanced Breast Cancer Therapies
- Genetic factors in colorectal cancer
- Thyroid Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Circular RNAs in diseases
- Bladder and Urothelial Cancer Treatments
- Cancer, Hypoxia, and Metabolism
- Reproductive System and Pregnancy
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Cell Adhesion Molecules Research
- Cancer-related Molecular Pathways
- Endometrial and Cervical Cancer Treatments
- Inflammatory Myopathies and Dermatomyositis
- Seaweed-derived Bioactive Compounds
- Single-cell and spatial transcriptomics
- FOXO transcription factor regulation
- Hippo pathway signaling and YAP/TAZ
Guangxi Medical University
2019-2025
First Affiliated Hospital of GuangXi Medical University
2019-2025
South China University of Technology
2024
Xinjiang Medical University
2021
First Affiliated Hospital of Xinjiang Medical University
2021
BACKGROUND Colorectal cancer (CRC) is a prevalent malignant tumor characterized by high mortality rate, with significant challenges persisting in the identification and management of its metastatic stage. The role checkpoint kinase 1 (CHEK1), cell cycle kinase, CRC has not been fully clarified. We hypothesize that upregulation CHEK1 may enhance proliferation cells, indicating potential as novel therapeutic target for therapy. AIM To investigate expression function CRC, this study utilizes...
Breast cancer cells release a large quantity of biocargo-bearing extracellular vesicles (EVs), which mediate intercellular communication within the tumour microenvironment and promote metastasis. To identify EV-bound proteins related to metastasis, we used mass spectrometry profile EVs from highly poorly metastatic breast lines human mouse origins. Comparative indicated that integrins, including αv β1 subunits, are preferentially enriched in origin over those origin. These results consistent...
Bladder cancer (BC) is the most common urological tumor. It has a high recurrence rate, displays tutor heterogeneity, and resists chemotherapy. Furthermore, long-term survival rate of BC patients remained unchanged for decades, which seriously affects quality patient survival. To improve prognosis patients, it necessary to explore molecular mechanisms development progression identify targets treatment intervention. Transmembrane 9 superfamily member 1 (TM9SF1), also known as MP70 HMP70,...
BACKGROUND Colorectal cancer (CRC) is the third most common globally, causing over 900000 deaths annually. Risk factors include aging, diet, obesity, sedentary lifestyle, tobacco use, genetic predisposition, and inflammatory bowel disease. Despite current treatments, survival rates for advanced CRC remain low, highlighting need better therapeutic strategies. AIM To evaluate both clinical significance pathological implications of Kinesin family member 14 (KIF14) expression within specimens....
Background Ferroptosis, as a novel modality of cell death, holds significant potential in elucidating the pathogenesis and advancing therapeutic strategies for breast cancer. Objective This study aims to comprehensively analyze current ferroptosis research future trends, guiding cancer advancements innovative treatment strategies. Methods used R package Bibliometrix (Department Economic Statistical Sciences at University Naples Federico II), VOSviewer (Centre Science Technology Studies...
Although great progress has been made in anti-cancer therapy, the prognosis of laryngeal squamous cell carcinoma (LSCC) patients remains unsatisfied. Quantities studies demonstrate that glycolytic reprograming is essential for progression cancers, where triosephosphate isomerase 1 (TPI1) serves as a catalytic enzyme. However, clinicopathological significance and potential biological functions TPI1 underlying LSCC obscure.We collected in-house 82 tissue specimens 56 non-tumor specimens....
Abstract Synaptojanin 2 (SYNJ2) has crucial role in various tumors, but its papillary thyroid carcinoma (PTC) remains unexplored. This study first detected SYNJ2 protein expression PTC using immunohistochemistry method and further assessed mRNA through chip RNA sequencing data association with clinical characteristics. Additionally, KEGG, GSVA, GSEA analyses were conducted to investigate potential biological functions, while single‐cell used explore SYNJ2's underlying mechanisms PTC....
Abstract Background Acid phosphatase type 6 (ACP6) is a mitochondrial lipid phosphate that played role in regulating metabolism and there still blank the clinico-pathological significance functional roles of ACP6 human cancers. No investigations have been conducted on hepatocellular carcinoma (HCC) up to date. Methods Herein, we appraised HCC via organizing expression profiles from globally multi-center microarrays RNA-seq datasets. The molecular basis was explored through multidimensional...
Although knowledge on metastatic breast cancer in bones (MBCB) has increased rapidly over the past 22 years, a comprehensive and objective bibliometric analysis is still lacking.We used R, VOSviewer, Citespace software to conduct of 5,497 papers MBCB from Web Science Core Collection (WOSCC) using author, institution, country/region, citation, keyword indicators.A general strong sense scholarly collaboration was noted field at research country/region levels. We discovered some outstanding...
The role of HOXA family genes in the occurrence and progression a variety human cancers has been scatteredly reported. However, there is no systematic study on differential expression, prognostic significance potential molecular mechanism HOXA4 HOXA5 LUAD.In-house immunohistochemistry (IHC), multi-center microarrays, RT-qPCR RNA-seq data were incorporated for comprehensively evaluating expression value LUAD. formation development LUAD was analyzed from multiple aspects immune correlations,...
Triple-negative breast cancer (TNBC) is the most malignant subtype of and lacks effective biomarkers. This study seeks to unravel expression status prospective transcriptional mechanisms EZH1/EZH2 in TNBC tissue samples. Moreover, another objective this reveal prognostic molecular signatures for risk stratification patients.To determine samples, microarray analysis immunohistochemistry were performed on house External mRNA matrices used verify its patterns. Furthermore, explored by...
BACKGROUND:Wilms tumor, or nephroblastoma, is a malignant pediatric embryonal renal tumor that has poor prognosis. This study aimed to use bioinformatics data, RNA-sequencing, connectivity mapping, molecular docking, and ligand-protein binding identify potential targets for drug therapy in Wilms tumor. MATERIAL AND METHODS:Wilms non-tumor samples were obtained from high throughput gene expression databases, differentially expressed genes (DEGs) analyzed using the voom method limma package....
Background. This study was aimed at elucidating the molecular biological mechanisms of microRNA-1 (miR-1) in nasopharyngeal carcinoma (NPC). Method. In this study, we performed a pooled analysis miR-1 expression data derived from public databases, such as GEO, ArrayExpress, TCGA, and GTEx. The miRWalk 2.0 database, combined with mRNA microarray datasets, used to screen target genes, genes were then subjected Kyoto Encyclopedia Genes Genomes (KEGG) Gene Ontology (GO) enrichment using DAVID...
Introduction: We aimed to explore the abnormal expression of dual-specificity protein phosphatase 1 (DUSP1) and its latent molecular mechanisms in ovarian carcinoma (OVCA). Materials Methods: Two clinical cohorts collected from two different hospitals were used evaluate DUSP1 OVCA tissues. RNA-sequencing microarray datasets utilised verify at mRNA levels both tissues peripheral blood patients. Furthermore, an integrated calculation was performed pool standard mean difference (SMD) each...
The aim of this study is to demonstrate the expression and clinicopathological significance complement C1q B chain (C1QB) in cervical cancer.In total, 120 cancer tissues, as well 20 samples each high-grade squamous intraepithelial lesions (HSILs), low-grade (LSILs), benign tissue, were collected evaluate C1QB protein via immunohistochemical staining. We conducted an integrated analysis mRNA using public microarrays RNA-seq data sets by calculating standard mean differences (SMDs)....
Abstract Background The molecular mechanism of laryngeal squamous cell carcinoma (LSCC) is not completely clear, which leads to poor prognosis and treatment difficulties for LSCC patients. To date, no study has reported the exact expression level zinc finger protein 71 (ZNF71) its in LSCC. Methods In-house immunohistochemistry (IHC) staining (33 samples 29 non-LSCC samples) was utilized analyzing ZNF71 Gene chips high-throughput sequencing data collected from multiple public resources (313...
Aim. To investigate the specific expression profile, clinicopathological significance and mechanism of Zic family member 2 (ZIC2) in oral cancer were unclear. Patients Methods. We explored pattern ZIC2 through performing in-house tissue microarray integrated analysis global RNA-seq microarrays containing large samples. The molecular basis was further investigated aspects transcription network immune correlations. also performed vitro experiments calculated drug sensitivity with different...
Objective At present, the structure of knowledge in field childhood thyroid cancer is not clear enough, and scholars lack a sufficient understanding developing trends this field, which has led to shortage forward-looking outputs. The purpose research help construct complete framework identify current challenges, opportunities, development trends. Methods We searched literature Web Science Core Collection database on August 7, 2023 extracted key information from top 100 most cited articles,...
<title>Abstract</title> Background Limited evidence suggests that nucleolar protein interacting with the FHA domain of MKI67 (NIFK) plays a significant role in tumour occurrence and development. The mechanism clinical value NIFK colorectal cancer (CRC) still lack comprehensive evaluation. Materials Methods Cancerous tissue paracancerous 266 CRC patients were collected for immunohistochemistry, mRNA expression profiles 2262 1297 non-CRC worldwide analysed at levels. Analyse effect knocking...
Despite advances in research on psychopathology and social media use, no comprehensive review has examined published papers this type of considered how it was affected by the coronavirus disease 2019 (COVID-19) outbreak.