A5078867623- Sperm and Testicular Function
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Reproductive Biology and Fertility
- Xenotransplantation and immune response
- Computational Drug Discovery Methods
- Renal and Vascular Pathologies
- Amino Acid Enzymes and Metabolism
- Vascular anomalies and interventions
- Testicular diseases and treatments
- Polyamine Metabolism and Applications
- T-cell and B-cell Immunology
- Epigenetics and DNA Methylation
- RNA Interference and Gene Delivery
- Thyroid Cancer Diagnosis and Treatment
- Nerve Injury and Rehabilitation
- Reproductive System and Pregnancy
- Immunotoxicology and immune responses
- Insect and Pesticide Research
- Shoulder Injury and Treatment
- Effects and risks of endocrine disrupting chemicals
- Lymphatic System and Diseases
- Insect and Arachnid Ecology and Behavior
- Neurobiology and Insect Physiology Research
- Genital Health and Disease
Tokyo Medical University
2015-2024
First Affiliated Hospital of GuangXi Medical University
2024
Guangxi Medical University
2024
Tokai University
2018-2024
Shanghai Institute of Materia Medica
2023-2024
University of Chinese Academy of Sciences
2023-2024
Chinese Academy of Sciences
2022-2024
State Key Laboratory of Drug Research
2023-2024
Northeast Agricultural University
2024
Northwest A&F University
2022
Most sporadic colon adenomas acquire mutations in the adenomatous polyposis coli gene ( APC ) and show defects -dependent signaling. influences expression of several genes, including c- myc oncogene its antagonist Mad1 . Ornithine decarboxylase (ODC), first enzyme polyamine synthesis, is a transcriptional target modifier tumorigenesis. A single-nucleotide polymorphism exists intron 1 human ODC gene, which lies between two -binding domains. This region known to affect transcription, but no...
Background: Despite advances in our understanding of basic mechanisms driving post-surgical pain, treating incision-induced pain remains a major clinical challenge. Moreover, surgery has been implicated as cause chronic conditions. Hence, more efficacious treatments are needed to inhibit and prevent the transition following surgery. We reasoned that activators AMP-activated protein kinase (AMPK) may represent novel treatment avenue for local because AMPK ERK mTOR signaling, two important...
This article evaluates the suitability of cadavers embalmed by saturated salt solution (SSS) method for surgical skills training (SST). SST courses using have been performed to advance a surgeon's techniques without any risk patients. One important factor improving is specimens, which depends on embalming method. In addition, infectious and cost involved in are problems that need be solved. Six were 3 methods: formalin solution, Thiel (TS), SSS methods. Bacterial fungal culture tests...
Ensuring drug safety in the early stages of development is crucial to avoid costly failures subsequent phases. However, economic burden associated with detecting off-targets and potential side effects through
The objective of this research was to study the effectiveness NaFeEDTA-fortified soy sauce for controlling iron deficiency in a high-risk population. This an 18-month, randomized, placebo-controlled intervention trial 14,000 residents aged three years or older Bijie City, Guizhou Province, China, using sodium-iron ethylene diamine tetraacetate (NaFeEDTA)-fortified (29.6 mg Fe/100 ml). data included measurements food consumption, hemoglobin, serum ferritin, and retinol. results showed that...
Risk prediction and clinical model building for lymph node metastasis in papillary thyroid microcarcinoma Dao-zhe Lin,1,* Ning Qu,2,3,* Rong-liang Shi,2,3 Zhong-wu Lu,2,3 Qing-hai Ji,2,3 Wei-li Wu1 1Department of Surgical Oncology, Rui'an People's Hospital, Third Affiliated Hospital Wenzhou Medical University, Wenzhou, 2Department Head Neck Surgery, Fudan University Shanghai Cancer Center, 3Department College, Shanghai, Republic China *These authors contributed equally to this work Abstract:...
Male infertility can be the result of many factors, including pathologies in motility and formation sperm as well obstructions genitourinary system. Oriental medicine, use multiple components to address various targets enhance therapeutic effectiveness, has been used treat male for thousands years. Given complex pathological mechanisms aspermatogenesis, this multi-target approach oriental medicine is believed positively impact prevention infertility. Efforts have made evaluate...
Abstract TC4, as a consequence of its low density, strong mechanical strength, and superior resistance to rust, is widely used in variety industries, including the chemical industry, aerospace, navigation. Yet, employment restricted few particular fields due hardness wear resistance. This work focuses on application laser cladding technology manufacture CoCrMo/TiC composite paints TC4 substrate with different TiC concentrations. The research employs XRD, OM, SEM, EDS examine layer’s makeup...
Transforming growth factor beta-1 (TGF-β1) signaling is increased and mitochondrial function decreased in multiple models of pulmonary hypertension (PH) including lambs with blood flow (PBF) pressure (Shunt). However, the potential link between TGF-β1 loss has not been investigated was focus our investigations. Our data indicate that exposure arterial endothelial cells (PAEC) to disrupted as determined by enhanced ROS generation, membrane potential, bioenergetics. These events resulted a...
Kinase-targeted inhibitors hold promise for new therapeutic options, with multi-target offering the potential broader efficacy while minimizing polypharmacology risks. However, comprehensive experimental profiling of kinome-wide activity is expensive, and existing computational approaches often lack scalability or accuracy understudied kinases. We introduce KinomeMETA, an artificial intelligence (AI)-powered web platform that significantly expands predictive range predicting...
Abstract Purpose: Activity of ornithine decarboxylase (ODC), the first enzyme in polyamine synthesis, is required for normal growth and elevated many cancers, including colorectal cancer. We examined associations +316 ODC1 single nucleotide polymorphism (SNP) with cancer–specific survival among cancer cases, then investigated its functional significance colon cells. Experimental Design: The study included 400 incident stage I-III cases from population-based University California Irvine...
The superior cluneal nerve (SCN) may become entrapped where it pierces the thoracolumbar fascia over iliac crest; this can cause low back pain (LBP) and referred radiating into posterior thigh, calf, occasionally foot, producing condition known as "pseudo-sciatica." Because SCN was thought to be a cutaneous branch of lumbar dorsal rami, originating from roots L1-L3, previous anatomical studies failed explain why causes "pseudo-sciatica". purpose present study better elucidate anatomy improve...
Lipophilicity is a fundamental physical property that significantly affects various aspects of drug behavior, including solubility, permeability, metabolism, distribution, protein binding, and toxicity. Accurate prediction lipophilicity, measured by the logD7.4 value (the distribution coefficient between n-octanol buffer at physiological pH 7.4), crucial for successful discovery design. However, limited availability data logD modeling poses significant challenge to achieving satisfactory...