A5100749478- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Gallbladder and Bile Duct Disorders
- Cardiac Imaging and Diagnostics
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Function and Risk Factors
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Prenatal Screening and Diagnostics
- Coding theory and cryptography
- Cancer, Lipids, and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Coronary Interventions and Diagnostics
- Reproductive System and Pregnancy
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Circular RNAs in diseases
- RNA Research and Splicing
- Congenital heart defects research
- Biliary and Gastrointestinal Fistulas
- Plasma Applications and Diagnostics
- Pancreatitis Pathology and Treatment
- Immune cells in cancer
First Hospital of Jilin University
2020-2025
Jilin University
2020-2025
Guangdong Pharmaceutical University
2025
Guangdong Medical College
2025
Xiangya Hospital Central South University
2023-2024
Central South University
2019-2024
Guangxi Maternal and Child Health Hospital
2021-2024
Xuzhou Medical College
2012-2024
First Affiliated Hospital of GuangXi Medical University
2021-2024
Taizhou People's Hospital
2024
Abstract Background Triglyceride glucose (TyG) index combined with obesity-related indicators [triglyceride glucose-body mass (TyG-BMI), triglyceride glucose-waist to height ratio (TyG-WHtR), circumference (TyG-WC)], represents emerging methodologies for assessing insulin resistance. The objective of this investigation was explore the correlation between TyG-related indices and gallstone disease. Methods study included 3740 adults from 2017–2020 period National Health Nutrition Examination...
Mitochondria are significant both for cellular energy production and reactive oxygen/nitrogen species formation. However, the functions of mitochondrial genes related to oxidative stress (MTGs-OS) in pancreatic cancer (PC) neuroendocrine tumor (PNET) yet be investigated integrally. Therefore, pan-cancer, particularly PC PNET, a thorough assessment MTGs-OS is required.Expression patterns, prognostic significance, mutation data, methylation rates, pathway-regulation interactions were studied...
Abstract The gut microbiota may have an effect on the therapeutic resistance and toxicity of immune checkpoint inhibitors (ICIs). However, associations between highly variable genomes bacteria effectiveness ICIs remain unclear, despite fact that merely a few gene mutations similar bacterial strains cause significant phenotypic variations. Here, using datasets from microbiome 996 patients seven clinical trials, we systematically identify microbial genomic structural variants (SVs) SGV-Finder....
It is universally acknowledged that long non-coding RNAs (lncRNAs) involved in tumorigenesis human cancers.However, the function and mechanism of many lncRNAs colorectal cancer (CRC) remain unclear.By analyzing two sets CRC-related gene microarrays data, downloaded from Gene Expression Omnibus (GEO) database lncRNA expression a set RNA sequencing we found SLCO4A1-AS1 was significantly upregulated CRC tissues.We then collected tissue samples verified highly expressed tissues.Furthermore, also...
Hepatocellular carcinoma (HCC) is a prevalent and heterogeneous tumor with limited treatment options unfavorable prognosis. The crucial role of disintegrin metalloprotease (ADAM) gene family in the microenvironment HCC remains unclear.
The trend of gallstones occurring in younger populations has become a noteworthy public health issue. This study aims to investigate the association between complete blood cell count (CBC)-derived inflammatory indicators and adults under 60 years age United States. cross-sectional used data from National Health Nutrition Examination Survey (NHANES) 2017 2020. Associations CBC-derived biomarkers were assessed using multivariable logistic regression models, with results presented as odds ratio...
Oxidative stress-induced cardiomyocyte apoptosis was the primary causative factor of cardiovascular disease (CVD). However, existing therapy drugs for oxidative stress were much less investigated, which underlined necessity new drug discovery and development. Herein, we aimed to synthesize several novel idebenone (IDE) derivatives investigate protective effect mechanism these against H2O2-induced injury in H9C2 cells by determining cell proliferation rate, detecting reactive oxygen species...
Lung cancer is the leading cause of deaths worldwide. Given that major threat metastasis, delineation molecular mechanism underlying it would help devise therapeutic strategies. Transglutaminase 2 (TG2), belonging to transglutaminase superfamily, a versatile protein with enzymatic and nonenzymatic functions. It mainly localizes inside cell, but also appears extracellularly. Recent findings have demonstrated involvement TG2 in development. Here we examine role metastasis lung using cell line...
Background The past decade has witnessed unprecedented scientific breakthroughs, including immunotherapy, which great potential in clinical applications for liver cancer. Methods Public data were obtained from Cancer Genome Atlas (TCGA) and International Consortium (ICGC) databases analyzed with R software. Results LASSO SVM-RFE machine learning algorithms identified 16 differentially expressed genes (DEGs) related to namely, GNG8, MYH1, CHRNA3, DPEP1, PRSS35, CKMT1B, CNKSR1, C14orf180,...
Purpose: To assess the regional systolic function in patients with post myocardial infarction (PMI), using velocity vector imaging (VVI) technique, a new two‐dimensional echocardiographic method. Methods: Two‐dimensional images of apical four, two chambers and long‐axis view were obtained 20 PMI 15 normal controls. The segmental peak strain (ε), rate (SRs), ejection fraction (SEF) analyzed VVI offline software. result ε middle segments control by was compared that tissue Doppler (DTI)....
Colorectal cancer (CRC) is one of the most common cancers worldwide. Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in tumorigenesis and development CRC. By constructing a differential lncRNA expression profile, we screened gene chips found DNAJC3-AS1 was highly expressed CRC tissues associated with poor prognosis patients Further, proved through assays such as wound healing, colony formation, Cell Counting Kit-8 (CCK8) interfering could reduce proliferation,...
Abstract The immune infiltration profiles of the tumor microenvironment have effects on prognosis head and neck squamous cell carcinoma (HNSCC). Whereas, HNSCC is a heterogeneous group tumors, but past work has not taken this into consideration. Herein, we investigate associations between survival function cells in different tumorigenic sites HNSCC. 1149 samples were collected from publicly accessible databases. Based gene expression data, CIBERSORTx was applied to determine proportion 22...
The WRKY gene family is crucial for regulating plant growth and development. However, the rarely studied in naked kernel formation hull-less Cucurbita pepo L. (HLCP), a natural mutant that lacks seed coat. In this research, 76 genes were identified through bioinformatics-based methods C. pepo, their phylogenetics, conserved motifs, synteny, collinearity, temporal expression during coat development analyzed. results showed CpWRKYs categorized into three main groups (I-III), with Group II...
Barium peritonitis is an inflammatory response that occurs when barium accidentally enters the abdominal cavity during a test. In extreme circumstances, it has potential to harm various organs and even result in death.
Background: Oleanolic acid has important hepatoprotective effects and inhibits liver tissue carcinogenesis. The aim of this study was to investigate the mechanism action oleanolic in inhibiting injury cancer. Method: In study, we applied differential gene analysis enrichment identify targets for treatment injury. And also Cibersort GSVA methods Based on targets, explored major further role This used oncoPredict TIDE algorithm predict effect drug resistance. Finally, binding relevant using...
Abstract Background Specific highly polarized aquaporin‐4 (AQP4) expression is reported to play a crucial role in blood‐brain barrier (BBB) integrity and brain water transport balance. The upregulation of polymerase δ‐interacting protein 2 (Poldip2) was involved aggravating BBB disruption following ischemic stroke. This study aimed investigate whether Poldip2‐mediated cerebral edema formation mouse bacterial meningitis (BM) model occur via induction AQP4 polarity loss. Methods Results Mouse...
p70 S6 kinase (S6K1) is a serine/threonine that phosphorylates the insulin receptor substrate-1 (IRS-1) at serine 1101 and desensitizes signaling. S6K1 hyperactivation due to overnutrition leads hyperglycemia type 2 diabetes. Our recent study showed A77 1726, active metabolite of anti-rheumatoid arthritis (RA) drug leflunomide, an inhibitor S6K1. Whether leflunomide can control sensitize has not been tested. Here we report 1726 increased AKT
Introduction. We aimed to explore the downregulation of coiled-coil domain containing 80 (CCDC80) and its underlying molecular mechanisms in ovarian carcinoma (OVCA). Materials/Methods. Immunohistochemical staining was performed confirm expression status CCDC80 protein. Combining data from in-house tissue microarrays high-throughput datasets, we identified level OVCA. utilized cell-type identification by estimating relative subsets RNA transcripts (CIBERSORT) algorithm single-sample gene set...
B-type natriuretic peptide (BNP) possesses protective cardiovascular properties; however, there has not been sufficient serious consideration of the side effects BNP. As for sarcoplasmic/endoplasmic reticulum calcium ATPase 2a (SERCA2a), it was once considered a new target treatment heart failure (HF). Nevertheless, clinical trials SERCA2a gene therapy in HF have finally become unsuccessful. Research found that elevated BNP levels and decreased expression are two important characteristics,...
ABSTRACT Purpose To explore the significance and value of speckle‐tracking echocardiography (STE) associated with low‐dose dobutamine stress (LDDSE) for detection viable myocardium (VM) in patients old myocardial infarction (OMI). Methods We performed STE LDDSE 33 hospitalized OMI left ventricular systolic dysfunction. QLAB software was used to analyze strain (S) rate (Sr). Percutaneous coronary intervention (PCI) subsequently performed. The movement each wall segment observed by routine...