A5077492377- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Advanced Breast Cancer Therapies
- Sustainable Building Design and Assessment
- Disaster Response and Management
- Lung Cancer Research Studies
- Urban Green Space and Health
- Global Health Care Issues
- Diet and metabolism studies
- Diabetes Treatment and Management
- Bladder and Urothelial Cancer Treatments
- Chronic Kidney Disease and Diabetes
- Blood Pressure and Hypertension Studies
- Diabetes Management and Research
- Fire effects on ecosystems
- Cancer Treatment and Pharmacology
- HER2/EGFR in Cancer Research
- Advanced ceramic materials synthesis
- Air Quality Monitoring and Forecasting
- Advanced Surface Polishing Techniques
- Advanced materials and composites
- Flood Risk Assessment and Management
- Intracerebral and Subarachnoid Hemorrhage Research
- Noise Effects and Management
- Facilities and Workplace Management
Monash University
2022-2025
Quality Research
2023-2025
Australian Regenerative Medicine Institute
2023-2025
Eli Lilly (United States)
2019-2025
Shandong Provincial Hospital
2025
Shandong University
2008-2025
Chongqing University
2023-2024
Children's Hospital of Zhejiang University
2024
Henan Institute of Geological Survey
2024
Chongqing Medical University
2020-2023
The primary objective was to evaluate intracranial response rate (iORR) in patients receiving abemaciclib with brain or leptomeningeal metastases (LM) secondary hormone receptor-positive (HR+) metastatic breast cancer (MBC). Secondary objectives evaluated extracranial response, pharmacokinetics, tissue exposure, and safety.This nonrandomized, phase II study (NCT02308020) enrolled tumor subtype-specific cohorts A-D: A (HR+, HER2- MBC), B HER2+ C (HR+ MBC LM), D (brain surgical resection)....
Wildfires are thought to be increasing in severity and frequency as a result of climate change1-5. Air pollution from landscape fires can negatively affect human health4-6, but exposure fire-sourced (LFS) air has not been well characterized at the global scale7-23. Here, we estimate daily LFS outdoor fine particulate matter (PM2.5) surface ozone concentrations 0.25° × resolution during period 2000-2019 with help machine learning chemical transport models. We found that overall...
To improve the application and service of Cf/SiC composites as advanced high-temperature structural materials, it is critical to achieve their high-efficiency low-damage machining. In this study, laser-ablating assisted grinding (LAAG) method was presented, connection damage behavior removal mechanism with laser processes revealed. The results demonstrated that surface after ablation covered a substantial number loose oxides primarily composed SiO2. Laser ablating process, parameter abrasive...
Clinical complications of atherosclerosis arise primarily as a result luminal obstruction due to atherosclerotic plaque growth, with inadequate outward vessel remodeling and destabilization leading rupture. IL-1 is proinflammatory cytokine that promotes atherogenesis in animal models, but its role unclear. The studies presented herein show advanced plaques mice lacking both receptor type I apolipoprotein E (Il1r1–/–Apoe–/– mice) unexpectedly exhibited multiple features instability compared...
Diarrhea causes enormous morbidity and mortality in developing countries, yet the relative importance of multiple potential enteropathogens has been difficult to ascertain.We performed a longitudinal cohort study from birth 1 year age 147 infants Dhaka, Bangladesh. Using multiplex polymerase chain reaction, we analyzed 420 episodes diarrhea 1385 monthly surveillance stool specimens for 32 enteropathogen gene targets. For each infant examined quantities over time ascribe positive target as...
To evaluate lag-response associations and effect modifications of exposure to floods with risks all cause, cardiovascular, respiratory mortality on a global scale.Time series study.761 communities in 35 countries or territories at least one flood event during the study period.Multi-Country Multi-City Collaborative Research Network database, Australian Cause Death Unit Record File, New Zealand Integrated Data Infrastructure, International for Demographic Evaluation Populations their Health...
Silent new ipsilateral ischemic lesions (sNIIL) detected by diffusion-weighted imaging (DWI) are commonly observed after carotid artery stenting (CAS). We aimed to analyze the association of plaque characteristics on Virtual Histology Intravascular Ultrasound (VH-IVUS) with sNIIL, which is not well understood. Among 128 patients who underwent CAS and VH-IVUS, 112 DWI within 72 h were included for analysis. VH-IVUS cross-sectional composition plaques including necrotic core (NC), dense...
Tirzepatide reduces HbA1c and body weight, creatinine-based estimated glomerular filtration rate (eGFR) decline. Unlike creatine-derived eGFR (eGFR-creatinine), cystatin C-derived (eGFR-cystatin C) is unaffected by muscle mass changes. We assessed effects of tirzepatide on eGFR-creatinine eGFR-cystatin C.Our primary outcome was change from baseline at 52 weeks with pooled (5, 10, 15 mg) titrated insulin glargine in adults type 2 diabetes high cardiovascular risk (SURPASS-4).Least squares...
BackgroundThe global spatiotemporal pattern of mortality risk and burden attributable to tropical cyclones is unclear. We aimed evaluate the short-term associated with from 1980 2019.MethodsThe wind speed 2019 was estimated globally through a parametric field model at grid resolution 0·5° × 0·5°. A total 341 locations daily temperature data 14 countries that experienced least one cyclone day (a maximum sustained ≥17·5 m/s) during study period were included. conditional quasi-Poisson...
Climate change presents a major public health concern in Australia, marked by unprecedented wildfires, heatwaves, floods, droughts, and the spread of climate-sensitive infectious diseases. Despite these challenges, Australia's response to climate crisis has been inadequate subject politics, sentiment, global developments. This study illustrates spatiotemporal patterns selected climate-related environmental extremes (heatwaves, droughts) across Australia during past two decades, summarizes...
Although some studies have found that short-term PM