A5101458948- Immune Cell Function and Interaction
- CAR-T cell therapy research
- Proteins in Food Systems
- Biosensors and Analytical Detection
- Innovative Microfluidic and Catalytic Techniques Innovation
- SARS-CoV-2 detection and testing
- T-cell and B-cell Immunology
- Microfluidic and Capillary Electrophoresis Applications
- Neurological disorders and treatments
- Protein Hydrolysis and Bioactive Peptides
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Infant Nutrition and Health
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Bacteriophages and microbial interactions
- Polydiacetylene-based materials and applications
- Virus-based gene therapy research
- Drug Transport and Resistance Mechanisms
- Pickering emulsions and particle stabilization
- Ferroptosis and cancer prognosis
- RNA regulation and disease
- MicroRNA in disease regulation
- Food Chemistry and Fat Analysis
- Microfluidic and Bio-sensing Technologies
Guangzhou Institutes of Biomedicine and Health
2019-2025
University of Hong Kong
2025
Tsinghua University
2017-2025
Jilin University
2023-2025
Jinan University
2023-2024
Huazhong University of Science and Technology
2016-2024
Wuhan Children's Hospital
2023-2024
Chinese University of Hong Kong
2024
National Institute for Viral Disease Control and Prevention
2024
Chinese Academy of Sciences
2019-2023
Orally targeting nanostrategies of multiple nutraceuticals have attracted increasing attention in ulcerative colitis (UC) therapy for superior patient compliance, cost-effectiveness, and biocompatibility. However, the actual delivery bioefficacy are extremely restricted by their poor solubility, interior gastrointestinal retention, base permeability. Herein, we developed controllable colon-targeting nanoparticles (NPs) composed a quaternary ammonium chitosan (HTCC) shell succinic...
Recently, oral deliverable strategies of multiple nutraceuticals for ulcerative colitis (UC) mitigation have attracted increasing attention. This study aimed to fabricate facile assemblies loaded with egg-white-derived peptides (EWDP) and curcumin based on carboxymethyl chitosan (CMCS) an γ-cyclodextrin metal–organic framework (MOF). Herein, outer CMCS could coassemble EWDP (both building blocks) into cobweb-like fibrils promote bridging inner MOF via coordinative noncovalent interactions...
Egg white proteins pose notable limitations in emulsion applications due to their inadequate wettability and interfacial instability. Polyphenol-driven alterations serve as an effective strategy for optimizing properties. Herein, covalent non-covalent complexes of egg proteins-proanthocyanins were synthesized. The analysis structural alterations, amino acid side chains was performed. superior (80.00° ± 2.23°) rigid structure (2.95 GPa) established favorable conditions utilization emulsions....
The "sample-to-answer" integration and automation of circulating tumor DNA (ctDNA)-based liquid biopsy using digital PCR (dPCR) has been hampered by the complicated operations liquids with volumes ranging from milliliter samples to nanoliter droplets. On basis a "3D extensible" design paradigm proposed previously, an integrated droplet (IddPCR) microdevice was successfully developed automate entire process biopsy, extraction ctDNA in 2 mL plasma magnetic beads generation, amplification,...
T cell infiltration into tumors is essential for successful immunotherapy against solid tumors. Herein, we found that the expression of hyaluronic acid synthases (HAS) was negatively correlated with patient survival in multiple types including gastric cancer. HA impeded vitro anti-tumor activities anti-mesothelin (MSLN) chimeric antigen receptor cells (CAR-T cells) cancer by restricting CAR-T mobility . We then constructed a secreted form human hyaluronidase PH20 (termed sPH20-IgG2)...
Abstract Co-expression of chimeric switch receptors (CSRs) specific for PD-L1 improves the antitumor effects antigen receptor (CAR) T cells. However, trans-recognition between CSRs and expressed by activated CAR cells remain unclear. Here, we design a CSR (CARP), containing transmembrane cytoplasmic signaling domains CD28 but not CD3 ζ chain. We show that CARP enhance activity anti-mesothelin (CARMz) in vitro vivo. In addition, confocal microscopy indicates molecules on CARMz accumulate at...
Abstract Tacrolimus (TAC)‐induced renal injury is detrimental to long‐term kidney function, but a treatment medication not available. Glycyrrhizic acid (GA) an active ingredient in licorice widely used treat disease. Thus, this study explored the mechanisms of renoprotection by GA on TAC‐induced injury. C57BL/6 mice were subjected daily TAC or combination and for 4 weeks, then histopathology, autophagy assessed examine effect Next, Human proximal tubular epithelial (HK‐2) cells pretreated...
Diarrheal disease remains a significant public health issue, particularly affecting young children and older adults. Despite efforts to control prevent these diseases, their incidence continues be global concern. Understanding the trends in diarrhea factors influencing is crucial for developing effective strategies.
Rapid protein detection is crucial for medical diagnosis, clinical trials, and drug development but often faces challenges in balancing sensitivity with multiplex detection, low reagent consumption, a short time. In this work, we developed an automated sensitive electroosmotic digital optofluidics (e-DOF) platform rapid label-free biomarker quantification microliter blood samples. The hyperspectral computation reveals nanoscale morphology changes caused by target capture, eliminating...
Inactivation of the transcription factor BCL11B reprograms T cells into induced-T-to-NK (ITNKs). However, it remains unclear how suppresses natural killer (NK) cell transcriptional programs. Here, we identified that DNA methyltransferase DNMT1 physically interacts with BCL11B, increasing stability and fidelity methylation maintenance for NK cell–related genes, thereby repressing their expression. Moreover, maintains epigenetic silencing a distinct subset genes independent BCL11B. inhibition...
Chimeric antigen receptor (CAR) T cell therapy lacks persistent efficacy with "on-target, off-tumor" toxicities for treating solid tumors. Thus, an antibody-guided switchable CAR vector, the chimeric Fc CD64 (CFR64), composed of a extracellular domain, is designed. cells expressing CFR64 exert more robust cytotoxicity against cancer than CFR high-affinity CD16 variant (CD16v) or CD32A as their domains. also exhibit better long-term and resistance to exhaustion compared conventional cells....
Abstract Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape dynamics of protein palmitoylation human cancers are not well understood. Methods We utilized 23 palmitoyl-acyltransferases seven de-palmitoyl-acyltransferases as palmitoylation-related genes for analysis. Multiple publicly available datasets were employed to conduct pan-cancer analysis, examining...
An integrated graphene oxide purification-lateral flow test strip (iGOP-LFTS) was developed for on-strip purifying and visually detecting polymerase chain reaction (PCR) products with an improved sensitivity as well a more stringent specificity. PCR amplified pair of biotin- digoxin-labeled primers were directly pipetted onto GO pads, on which selectively adsorbed residual primer-dimers the aid running buffer containing MgCl2 Tween 20. By stacking up three pads to increase surface area...
Adoptive cell therapy (ACT) is a particularly promising area of cancer immunotherapy, engineered T and NK cells that express chimeric antigen receptors (CAR) are being explored for treating hematopoietic malignancies but exhibit limited clinical benefits solid tumour patients, successful cellular immunotherapy tumors demands new strategies.Inactivation BCL11B were performed by CRISPR/Cas9 in human cells. Immunophenotypic transcriptional profiles sgBCL11B characterized cytometer...