A5025034720- Bacterial Genetics and Biotechnology
- Cancer, Lipids, and Metabolism
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Cancer, Hypoxia, and Metabolism
- Biochemical and Molecular Research
- Ferroptosis and cancer prognosis
- Gene Regulatory Network Analysis
- Photosynthetic Processes and Mechanisms
- Nanoplatforms for cancer theranostics
- Metabolism and Genetic Disorders
- Plant biochemistry and biosynthesis
- ATP Synthase and ATPases Research
- Cytomegalovirus and herpesvirus research
- Evolution and Genetic Dynamics
- Cancer Treatment and Pharmacology
- CRISPR and Genetic Engineering
- Bioinformatics and Genomic Networks
- Adenosine and Purinergic Signaling
- Drug Transport and Resistance Mechanisms
- Microbial Natural Products and Biosynthesis
- Salmonella and Campylobacter epidemiology
- Prostate Cancer Treatment and Research
- RNA and protein synthesis mechanisms
- Cancer Research and Treatments
Shenzhen Institutes of Advanced Technology
2023-2025
Chinese Academy of Sciences
2022-2025
Chinese Academy of Agricultural Sciences
2022-2024
Agricultural Genomics Institute at Shenzhen
2022-2024
Ministry of Agriculture and Rural Affairs
2024
University of Chinese Academy of Sciences
2022
South China Sea Institute Of Oceanology
2022
Institute of Oceanology
2022
Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou)
2022
Guangdong Technion-Israel Institute of Technology
2022
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of highly functionalized diterpenoid core skeleton (baccatin III) and subsequent assembly phenylisoserinoyl side chain. Despite intensive investigation for half century, complete biosynthetic pathway baccatin III remains unknown. In this work, we identified bifunctional cytochrome P450 enzyme [taxane oxetanase 1 (TOT1)] in
Metabolic reprogramming is a hallmark of cancer. However, it not well known how metabolism affects cancer progression. We identified that metabolic enzyme acyl-CoA oxidase 1 (ACOX1) suppresses colorectal (CRC) progression by regulating palmitic acid (PA) reprogramming. ACOX1 highly downregulated in CRC, which predicts poor clinical outcome CRC patients. Functionally, depletion promotes cell proliferation vitro and tumorigenesis mouse models, whereas overexpression inhibits patient-derived...
Metabolic reprogramming is a hallmark of cancer. rate-limiting enzymes and oncogenic c-Myc (Myc) play critical roles in metabolic to affect tumourigenesis. However, systematic assessment their relationship with Myc human cancers lacking.Multiple Pan-cancer datasets were used develop the transcriptome, genomic alterations, clinical outcomes correlation landscapes 168 across 20 cancers. Real-time quantitative PCR immunoblotting were, respectively, examine mRNA protein inosine monophosphate...
Bacteria are capable of sensing and responding to environmental changes by several signal transduction systems with different mechanisms. Much attention is paid model organisms complex signaling networks understand their composition function, but how a complicated network evolved from simple one or vice versa lacks systematic studies.
Abstract Background Protein palmitoylation, which is catalyzed by palmitoyl-transferase and de-palmitoyl-transferase, plays a crucial role in various biological processes. However, the landscape dynamics of protein palmitoylation human cancers are not well understood. Methods We utilized 23 palmitoyl-acyltransferases seven de-palmitoyl-acyltransferases as palmitoylation-related genes for analysis. Multiple publicly available datasets were employed to conduct pan-cancer analysis, examining...
Various forms of solid tumors harbor intracellular bacteria, but the physiological consequences these microorganisms are poorly understood. We show that Campylobacter is significantly enriched in primary colorectal cancer (CRC) lesions from patients with metastasis. jejuni-derived cytolethal distending toxin (CDT) promotes CRC metastasis through JAK2-STAT3-MMP9 signaling liver or pulmonary metastatic mice models, as confirmed C. jejuni-infected human colonic tissue and CDT-treated tumoroids...
The evolution of macromolecular complex is a fundamental biological question, which related to the origin life and also guides our practice in synthetic biology. chemosensory system one structures that evolved very early bacteria displays enormous diversity complexity terms composition array structure modern species. However, how remains unclear. Here, using Campylobacterota phylum with robust “eco-evo” framework, we investigated co-evolution its important signaling outputs, flagellar...
Abstract Microbes rely on signal transduction systems to sense and respond environmental changes for survival reproduction. It is generally known that niche adaptation plays an important role in shaping the signaling repertoire. However, evolution of bacterial capacity lacks systematic studies with a temporal direction. Particularly, it unclear how complexity evolved from simplicity or vice versa networks. Here we examine evolutionary processes major Campylobacterota (formerly...
Archaea are capable of sensing and responding to environmental changes by several signal transduction systems with different mechanisms. Much attention is paid model organisms complex signaling networks understand their composition function, but general principles regarding how an archaeal species organizes its chemoreceptor diversity habitat adaptation poorly understood.