A5101449585- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- Marine Sponges and Natural Products
- Carbohydrate Chemistry and Synthesis
- Chemical Synthesis and Analysis
- Microbial Natural Products and Biosynthesis
- Robotics and Automated Systems
- Oxidative Organic Chemistry Reactions
- Plant Stress Responses and Tolerance
- Plant Micronutrient Interactions and Effects
- DNA and Biological Computing
- Synthesis of heterocyclic compounds
- Magnolia and Illicium research
- Fluorine in Organic Chemistry
- Chemical Synthesis and Reactions
- interferon and immune responses
- RNA regulation and disease
- Aluminum toxicity and tolerance in plants and animals
- Pharmacological Effects of Natural Compounds
- Cancer Treatment and Pharmacology
- Echinoderm biology and ecology
- Advanced Scientific Research Methods
- Synthesis and biological activity
- Marine Toxins and Detection Methods
- Plant biochemistry and biosynthesis
Agricultural Genomics Institute at Shenzhen
2023-2024
Chinese Academy of Agricultural Sciences
2023-2024
Ministry of Agriculture and Rural Affairs
2024
South China Agricultural University
2023-2024
Peng Cheng Laboratory
2024
Chinese University of Hong Kong, Shenzhen
2024
Beijing Jiaotong University
2019-2023
Jinan Central Hospital
2022
Shandong University
2022
Scripps Research Institute
2010-2012
Paclitaxel is a well known anticancer compound. Its biosynthesis involves the formation of highly functionalized diterpenoid core skeleton (baccatin III) and subsequent assembly phenylisoserinoyl side chain. Despite intensive investigation for half century, complete biosynthetic pathway baccatin III remains unknown. In this work, we identified bifunctional cytochrome P450 enzyme [taxane oxetanase 1 (TOT1)] in
An improved sulfenylation method for the preparation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines from diketopiperazines has been developed. Employing NaHMDS related bases elemental sulfur or bis[bis(trimethylsilyl)amino]trisulfide (23) in THF, developed was applied to synthesis a series natural designed molecules, including epicoccin G (1), 8,8'-epi-ent-rostratin B (2), gliotoxin (3), (4), emethallicin E (5), haematocin (6). Biological screening selected synthesized...
Palmerolide A is a recently disclosed marine natural product possessing striking biological properties, including potent and selective activity against the melanoma cancer cell line UACC-62. The total syntheses of five palmerolide stereoisomers, originally proposed (1) revised [ent-(19-epi-20-epi-1)] structures, have been accomplished. highly convergent flexible strategy developed for these involved construction key building blocks 2, 19-epi-2, 20-epi-2, ent-2, 3, ent-3, 4, ent-4, their...
Marine engineering: A modular strategy featuring an intramolecular 1,4-addition/aldol/dehydration cascade sequence (see scheme; TBS=tert-butyldimethylsilyl) has enabled the total synthesis of cortistatin A, a potent anti-angiogenic marine natural product. This flexible route offers access to other members family, both and designed.
Total syntheses of the highly selective antiproliferative natural products cortistatins A (1) and J (5) in their naturally occurring enantiomeric forms are described. The modular convergent strategy employed relies on an intramolecular oxa-Michael addition/aldol/dehydration cascade reaction to cast ABCD ring framework molecule both Sonogashira Suzuki−Miyaura coupling reactions assemble necessary building blocks into required heptacyclic skeleton. divergent approach from a late-stage epoxy...
Brassica campestris L., a cadmium (Cd) hyperaccumulating herbaceous plant, is considered as promising candidate for the bioremediation of Cd pollution. However, molecular mechanisms regulating these processes remain unclear. The present work, using proteome studies combined with transcriptome analysis, was carried out to reveal response hairy roots L. under stress. Significant tissue necrosis and cellular damage occurred, accumulation observed in cell walls vacuoles roots. Through...
Semantic communication is widely touted as a key technology for propelling sixth-generation (6G) wireless networks. However, providing effective semantic representation quite challenging in practice. To address this issue, article takes crack at exploiting knowledge base (KB) to usher new era of generative communication. Via KB, source messages can be characterized low-dimensional subspaces without compromising their desired meanings, thus significantly enhancing the efficiency. The...
In the palm of your hand: Total syntheses originally proposed and revised structures marine antitumor agent palmerolide A (see picture, structure had opposite configurations at positions indicated in red) were accomplished through a modular strategy that features ring-closing metathesis to stereoselectively form C8C9 bond concurrently macrocycle.
Molecular design and chemical synthesis of several palmerolide A analogues allowed the first structure activity relationships (SARs) this newly discovered marine antitumor agent. From synthesized tested (ent-1, 5−14, 21−26, 50, 51), compounds 25 (with a phenyl substituent on side chain) 51 (lacking C-7 hydroxyl group) were most interesting, exhibiting approximately 10-fold increase in potency equipotency, respectively, to natural product. These findings point way more focused relationship studies.
Two make a cycle: A Ramberg–Bäcklund reaction was employed to form the macrocyclic carbon skeleton of marine natural products cylindrocyclophanes and F in an asymmetric synthesis through head-to-tail dimerization approach (see scheme).
Solanum nigrum L., a hyperaccumulator of cadmium (Cd), is regarded as promising candidate for phytoremediation heavy metal pollution. In the present study, hairy roots L. were selected model plant system to study potential application Iron-regulated Transporter Gene (IRT1) efficient Cd The transgenic expressing IRT1 gene from Arabidopsis thaliana successfully obtained via Agrobacterium tumegaciens-mediated method. Expression reduced stress-induced phytotoxic effects. Significantly superior...
Brassica campestris L., a hyperaccumulator of cadmium (Cd), is considered candidate plant for efficient phytoremediation. The hairy roots L are chosen here as model system to investigate the response mechanism L. Cd stress. High-throughput sequencing technology used identify genes related tolerance. A total 2394 differentially expressed (DEGs) identified by RNA-Seq analysis, among which 1564 up-regulated, and 830 down-regulated. Data from gene ontology (GO) analysis indicate that DEGs mainly...
Endometrial cancer is the major type of gynecological and ranks as sixth most common in women. usually diagnosed an advanced stage, complicating treatments many cases. The present research was focused on unveiling vitro anticancer role fucoxanthin against endometrial HEC-1A cells by inhibiting phosphatidylinositol-3-kinase/Akt/mammalian target rapamycin (PI3K/Akt/mTOR) signaling axis. cytotoxicity studied using MTT test. level reactive oxygen species (ROS) production, mitochondrial membrane...
An efficient enantioselective route to nonactin using a novel β-inversion of an Evans syn aldol construct the THF ring is presented. Through total synthesis, structure for trilactone proposed in literature shown likely be incorrect.
The title compound was synthesized through an expeditious route using Crimmins aldolization to establish the two key stereogenic centers and a hydroxyl group activation (HGA) protocol construct anti α,β-disubstituted β-lactone from corresponding syn aldol.
Ein flexibler Start: Eine modulare Strategie, die eine Folge aus intramolekularer 1,4-Addition, Aldolreaktion und Dehydratisierung umfasst (siehe Schema; TBS=tert-Butyldimethylsilyl), ermöglichte Totalsynthese von Cortistatin A, einem wirksamen anti-angiogenen marinen Naturstoff. Diese flexible Route bietet einen Zugang zu anderen Mitgliedern der Cortistatin-Familie, natürlichen wie gezielt entworfenen. Supporting information for this article is available on the WWW under...
An effective approach to the total synthesis of natural antibiotic pamamycin 621A is described, in which stereogenic centers at C-13 and C-15 were taken from a chiral building block derived inexpensive d-glucolactone while all others (except C-10) installed via auxiliary-induced asymmetric Evans/Crimmins aldol reactions. In smaller/lower fragment, an antiselective Evans condensation was found occur only if stoichiometric (rather than catalytic as reported literature) amount magnesium...
Hot-stamped steel has been widely used in automobile bumper and other safety components due to its high strength. Therefore, this paper investigates the effect of hydrogen content strain rate on hydrogen-induced delay cracking (HIDC) behavior. The results showed that plasticity significantly decreased with an increase or a decrease rate. Fractography was analyzed after tensile tests. It found all pre-charged specimens cracked at large-sized inclusions when stretched 1 × 10−3 s−1, which...
Auf der Hand: Die Totalsynthesen ursprünglich vorgeschlagenen und korrigierten Struktur des marinen Krebstherapeutikums Palmerolid A (siehe Bild, in waren die rot wiedergegebenen Zentren anders konfiguriert) gelangen mit einer modularen Strategie, eine Ringschlussmetathese umfasst, um stereoselektiv C8C9-Bindung aufzubauen zugleich den Makrocyclus zu bilden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2007/z702243_s.pdf or...
Zwei bilden einen Kreis: Eine Ramberg-Bäcklund-Reaktion wurde für den Aufbau des makrocyclischen Kohlenstoffgerüsts der marinen Naturstoffe Cylindrocyclophan A und F in einer asymmetrischen Synthese durch Kopf-Schwanz-Dimerisierung genutzt (siehe Schema). Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents peer-reviewed, but not copy-edited or typeset. They made available submitted by the authors. Please note: The publisher is...
Schwefel in Aktion: Eine praktische und einfache Methode zur Einführung von Schwefelatomen 2,5-Diketopiperazine (I) unter milden Bedingungen wurde entwickelt. Die Reaktion liefert Epidithiodiketopiperazine (II) Bismethylthiodiketopiperazine (III) verschiedenster Komplexität.
The pleiotropic biologic effects of interferon (IFN) are mediated through regulation the expression numerous IFN-sensitive genes. Peripheral blood mononuclear cells (PBMCs) obtained from healthy donors were analyzed to study immunoregulatory and antiviral messenger RNAs (mRNAs) proteins regulated by pegylated IFN-α2b (PEG-IFN-α2b) IFN-α2b. A dose-dependent time-dependent response for multiple IFN-regulated genes was observed. IFN-dependent protein production secretion correlated with mRNA...
β-Hydroxy acids were readily converted into β-tosyloxy (hydroxyl group activation) in moderate to excellent yields via the O,O-dianions generated by treatment with methyllithium and thus make it possible prepare anti α,β-disubstituted β-lactones directly from syn aldols.