A5071334213- Occupational Health and Safety Research
- Nanoplatforms for cancer theranostics
- Robotic Path Planning Algorithms
- Bacterial biofilms and quorum sensing
- Human-Automation Interaction and Safety
- Traffic and Road Safety
- Advanced Nanomaterials in Catalysis
- Risk and Safety Analysis
- Innovations in Concrete and Construction Materials
- Biofuel production and bioconversion
- Advanced Photocatalysis Techniques
- Catalysis for Biomass Conversion
- Inhalation and Respiratory Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Ammonia Synthesis and Nitrogen Reduction
- Biomedical Text Mining and Ontologies
- 3D Surveying and Cultural Heritage
- BIM and Construction Integration
- Infrastructure Maintenance and Monitoring
- Advanced Manufacturing and Logistics Optimization
- Antimicrobial agents and applications
- Microbial Metabolic Engineering and Bioproduction
- Online and Blended Learning
- Advanced Chemical Sensor Technologies
- Machine Fault Diagnosis Techniques
Zhejiang University
2018-2025
Nantong University
2025
Johns Hopkins University
2024
Macau University of Science and Technology
2024
Beijing University of Posts and Telecommunications
2024
University of Chicago
2024
Shaanxi University of Science and Technology
2024
Tangshan Normal University
2024
China Southern Power Grid (China)
2024
Zhejiang Lab
2024
Chronic lung infection caused by bacterial biofilms is an extremely serious clinical problem, which can lead to the failure of antibiotic therapy. Although nanoparticles have shown great potential in treatment biofilms, efficient penetration and retention still a big challenge. To address this issue, we herein fabricate size charge adaptive azithromycin (AZM)-conjugated clustered (denoted as AZM-DA NPs) therapeutic agents for treating biofilms. The NPs are prepared electrostatic complexation...
Inhibition of quorum sensing (QS) is considered as an effective strategy in combatting biofilm-associated bacterial infections. However, the application inhibitors (QSI) strongly restricted by poor water-solubility and low bioavailability. We herein fabricate pH-sensitive curcumin (Cur) loaded clustered nanoparticles with active targeting ability (denoted anti-CD54@Cur-DA NPs) to inhibit QS for enhanced antibiotic therapy. Cur-DA NPs are first prepared through electrostatic interaction...
Electrochemical nitrate (NO3-) reduction in aqueous media provides a useful approach for ammonia (NH3) synthesis. While efforts are focused on developing catalysts, the local microenvironment surrounding catalyst centers is of great importance controlling electrocatalytic performance. Here, we demonstrate that self-assembled molecular iron integrated free-standing conductive hydrogel capable selective production NH3 from NO3- at efficiencies approaching unity. With hydrogel, selectivity...
Resting sweat analysis could provide unique insight into the metabolic levels of physiological and pathological states. However, low secretion rate resting concentration molecules pose challenges for development noninvasive wearable sensors. Here, we demonstrated a patch precise uric acid at rest. Fe single-atom nanozymes (FeSAs) with excellent electrocatalytic activity were used to develop sensor selective catalysis (UA, 1-425 μM), catalytic mechanism UA was later explored by density...
In the workplace, some workers tend to have a higher probability of incurring an accident. Such individuals might behave unsafely because they assign low priority safety. Some evidence in literature suggests that people's personalities could influence their safety behavior at work. However, it seems correlation between construction workers' personality traits and has been insufficiently addressed existing literature. This paper attempts provide on this issue. Two hundred eighty were surveyed...
Abstract The decade‐old antibiotic, polymyxin B (PMB), is regarded as the last line defense against gram‐negative “superbug.” However, serious nephrotoxicity and neurotoxicity strongly obstruct further application of this highly effective antibiotic. Herein, a charge switchable polyion nanocomplex exhibiting pH‐sensitive property proposed to deliver PMB which expected improve biosafety on premise retaining excellent antibacterial activity. prepared through electrostatic interaction...
Featured with a zero-autofluorescence background, superior signal-to-noise ratio, high sensitivity, and deep penetration ability, near-infrared persistent luminescence nanoparticle (NIR-PLNP)-based multimodal nanoprobes show great potential for full-scale noninvasive cancer diagnosis. However, direct synthesis of NIR-PLNP-based drug loading capacity to meet growing theranostic demands remains challenge. In this work, multifunctional hybrid mesoporous nanoparticles (HMNPs) that integrate NIR-PLNPs (Ga
This study investigates the impact of embedded questions in pre-class instructional videos on learner perceptions (cognitive load, emotional engagement, satisfaction, judgement learning), video engagement (total views, total viewing time), and learning performance (retention, transfer). The research occurred a real flipped classroom environment. We designed quasi-experiment which 86 university students from two natural classes watched featuring procedural knowledge with or without...
Brassica campestris L., a cadmium (Cd) hyperaccumulating herbaceous plant, is considered as promising candidate for the bioremediation of Cd pollution. However, molecular mechanisms regulating these processes remain unclear. The present work, using proteome studies combined with transcriptome analysis, was carried out to reveal response hairy roots L. under stress. Significant tissue necrosis and cellular damage occurred, accumulation observed in cell walls vacuoles roots. Through...
Abstract Photodynamic therapy (PDT) is believed to be a potent method for biofilm treatments. However, undesired damage normal cells may caused due the nonselective nature of PDT. Therefore, targeted PDT preferred on one hand enhance antimicrobial effects and other reduce cytotoxicity cells. For this purpose, novel bacteria‐targeted photosensitizer delivery micelles are fabricated, taking advantage α‐cyclodextrin (α‐CD)/polyethylene glycol (PEG) supramolecular assembly. Hydrophilic peptide...
Abstract Although numerous antibiotics have been developed and applied in clinic, bacterial infections are still serious threats to human health, due the rapidly growing antibiotic resistance all over world. The causes of include two main aspects: formation biofilms self‐evolution bacteria under selection pressure. It is great significance develop effective strategies treat with resistance. With excellent performance, such as size effect, specific physicochemical property, easy modification,...
Abstract The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the closeended question-answering (QA) task with answer options for evaluation. However, many clinical decisions involve answering open-ended questions without pre-set options. To better understand LLMs in clinic, we construct a benchmark ClinicBench . We first collect eleven existing datasets covering diverse generation, understanding, and reasoning...